Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
The telemetry monitor suddenly shows a chaotic waveform resembling ventricular fibrillation, but the patient is talking and brushing their teeth. What should the nurse do first?
ADeliver an immediate defibrillation shock before checking anything
BGive IV amiodarone as a bolus
CCheck the patient and the electrodes, as this is likely artefact
DStart chest compressions straight away and call the arrest team
2.Med-surg: cardiovascular & respiratoryHard
A patient taking ramipril and indapamide for hypertension starts regular ibuprofen for back pain. A week later, creatinine has risen sharply. What is the most likely cause?
AAn ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
BBack pain causing kidney damage
CAn allergic reaction to the diuretic causing inflammation of the kidney
DIbuprofen raising the blood pressure to levels that damage the kidneys
3.Med-surg: neuro, endocrine & renalMedium
A patient on insulin asks about drinking alcohol. Which advice is correct?
AAlcohol can cause hypos, even the next day, so eat carbs with it
BAlcohol raises glucose, so extra insulin should be taken first
CAlcohol has no effect on blood glucose in people with diabetes
DAlcohol should replace a meal on the days it is drunk
4.Med-surg: neuro, endocrine & renalHard
A patient with Guillain–Barré syndrome has a blood pressure that swings between 80/50 and 190/100 mmHg and a heart rate that changes suddenly. What does this suggest?
AA faulty blood pressure cuff that should be replaced and the readings ignored
BA drug reaction that means all medicines must stop
CAnxiety that will settle with reassurance alone
DAutonomic dysfunction, which needs continuous cardiac monitoring
5.Med-surg: GI, perioperative & oncologyMedium
Which is a common side effect of opioids, especially when given by epidural or spinal route?
AItching
BHair growth
CIncreased hunger
DRinging in the ears
6.Med-surg: GI, perioperative & oncologyHard
A patient receiving filgrastim (G-CSF) after chemotherapy asks which side effect to expect. Which side effect is most common?
AAching bone pain, as the bone marrow is stimulated
BComplete hair loss within days of the first injection
CA rapid fall in the white cell count
DPermanent hearing loss
7.Clinical nursingMedium
Which advice is important for a patient on long-term oral corticosteroids?
ATake them only when symptoms flare
BTake them on an empty stomach at night
CDouble the dose if a dose is missed
DDo not stop them suddenly
8.Clinical nursingHard
A nurse is unsure whether a prescribed dose of a high-risk drug is correct. What is the safest action?
AGive half the dose as a compromise until the doctor is available
BAsk the patient whether the dose looks the same as usual and give it
CGive the dose because the doctor has signed the prescription
DWithhold it and check with the prescriber or pharmacist first
9.Lab values & electrolytesMedium
A patient’s white cell count is 16 × 10³/µL with a high proportion of immature neutrophils (bands). What does this most likely indicate?
AAn acute bacterial infection
BA normal result
CIron-deficiency anemia
DA chronic viral illness only
10.Lab values & electrolytesHard
The nurse teaches a patient with iron-deficiency anemia who is starting oral iron. Which statement shows a need for further teaching?
A"I can take it with orange juice to help absorption"
B"My stools may look darker while I take the tablets"
C"I'll keep the tablets out of reach of the children"
D"I'll take my iron tablet with a big glass of milk"
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.14, PaCO₂ 43 mmHg (5.7 kPa) and HCO₃⁻ 14 mmol/L. The primary disorder is metabolic acidosis. How far is it compensated? Click your answer.
pH 7.14PaCO₂ 43 mmHg (5.7 kPa)HCO₃⁻ 14 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 46 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 46 mmol/L
PaCO₂ = mmHg
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1atrial flutter, 2:1 conduction
2supraventricular tachycardia (SVT)
3torsades de pointes
4ventricular fibrillation
15.Prioritization & delegationMedium
A patient receiving an aminoglycoside antibiotic, such as gentamicin, reports ringing in the ears. What should the nurse do?
AHold the next dose and report it promptly
BAdvise the patient to use ear drops
CReassure the patient that it is a normal effect
DGive the next dose early to finish the course
16.Prioritization & delegationHard
A patient on a cardiac monitor suddenly becomes unresponsive, and the monitor shows ventricular fibrillation. What is the priority once help has been called?
ACheck the blood potassium level before any shock is considered
BGive an oral antiarrhythmic tablet and recheck the rhythm in five minutes
CRecord a full 12-lead ECG to confirm the rhythm before doing anything else at all
DDefibrillate as soon as the defibrillator is available, with CPR until then
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Check the patient and the electrodes, as this is likely artefact
Why this is the answer
Movement, loose electrodes and muscle activity can create artefact that looks like VF. A conscious, talking patient cannot be in VF. The nurse assesses the patient and checks the leads and electrodes, then reattaches them if needed.
Answer
C · Check the patient and the electrodes, as this is likely artefact
2.Med-surg: cardiovascular & respiratory
Answer: A · An ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
Why this is the answer
NSAIDs constrict the afferent arteriole, ACE inhibitors dilate the efferent arteriole and diuretics reduce volume. Together (sometimes called the "triple whammy") they can cause acute kidney injury. The NSAID is stopped, and the prescriber reviews the other drugs.
Answer
A · An ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
3.Med-surg: neuro, endocrine & renal
Answer: A · Alcohol can cause hypos, even the next day, so eat carbs with it
Why this is the answer
Alcohol reduces the liver's release of glucose, so it increases the risk of hypoglycaemia, which may be delayed for many hours. Patients should eat carbohydrate, check glucose before bed and tell friends that a hypo can look like drunkenness.
Answer
A · Alcohol can cause hypos, even the next day, so eat carbs with it
4.Med-surg: neuro, endocrine & renal
Answer: D · Autonomic dysfunction, which needs continuous cardiac monitoring
Why this is the answer
Guillain–Barré syndrome can involve autonomic nerves, causing labile blood pressure and dangerous arrhythmias. Patients need continuous ECG monitoring and close observation, often in a high-dependency setting.
Answer
D · Autonomic dysfunction, which needs continuous cardiac monitoring
5.Med-surg: GI, perioperative & oncology
Answer: A · Itching
Why this is the answer
Pruritus is common with neuraxial opioids. Other common effects include nausea, urinary retention, constipation and sedation; respiratory depression is the most serious.
Answer
A · Itching
6.Med-surg: GI, perioperative & oncology
Answer: A · Aching bone pain, as the bone marrow is stimulated
Why this is the answer
Granulocyte colony-stimulating factors stimulate the marrow to make neutrophils, which often causes aching bone pain, especially in the back, pelvis and long bones; it is usually managed with simple analgesia as prescribed. A rare but serious effect is splenic rupture, so new left upper abdominal or shoulder-tip pain must be reported at once.
Answer
A · Aching bone pain, as the bone marrow is stimulated
7.Clinical nursing
Answer: D · Do not stop them suddenly
Why this is the answer
Long-term steroids suppress the adrenal glands, so stopping suddenly can cause adrenal crisis. Patients should carry a steroid alert card or medical ID and follow sick-day guidance.
Answer
D · Do not stop them suddenly
8.Clinical nursing
Answer: D · Withhold it and check with the prescriber or pharmacist first
Why this is the answer
Nurses must understand any drug they administer. If a dose seems wrong, they should check with the prescriber or pharmacist and document the action.
Answer
D · Withhold it and check with the prescriber or pharmacist first
9.Lab values & electrolytes
Answer: A · An acute bacterial infection
Why this is the answer
A raised white count with more bands (a “left shift”) suggests that the marrow is responding to an acute bacterial infection or severe inflammation. The result is read together with the patient’s signs, such as fever.Checked against:Blood Differential · MedlinePlus (NIH) (2024)
Answer
A · An acute bacterial infection
10.Lab values & electrolytes
Answer: D · "I'll take my iron tablet with a big glass of milk"
Why this is the answer
Calcium in milk, as well as antacids and tea, reduces iron absorption, so iron should not be taken with them. Vitamin C improves absorption, dark stools are expected, and iron overdose is a serious poisoning risk in young children.Checked against:Iron deficiency anemia - Medical Encyclopedia · MedlinePlus (NIH) (2025); Iron in diet - Medical Encyclopedia · MedlinePlus (NIH) (2025)
Answer
D · "I'll take my iron tablet with a big glass of milk"
11.Arterial blood gas interpretation
Answer: uncompensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.14: acidaemia (below 7.35)
PaCO₂ 43 mmHg: normal (35–45)
HCO₃⁻ 14 mmol/L: low (22–26)
Compensation
Clinically, also check the expected compensation: Winter’s formula expects PaCO₂ 27–31 mmHg, so the measured 43 mmHg points to an additional respiratory acidosis (a mixed disorder). The answer above is the ROME exam classification.
uncompensated
Answer
uncompensated
12.Arterial blood gas interpretation
Answer: PaCO₂ = 53.2 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·46 + 21 = 53.2 mmHg
Answer
PaCO₂ = 53.2 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
13.ECG rhythm strip interpretation
Answer: QTc = 0.501 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 13 × 0.04 = 0.52 s
RR = 28 × 0.04 = 1.12 s
Fridericia’s formula
QTc = 0.52/∛1.12 = 0.52/1.038 = 0.501 s
Answer
QTc = 0.501 s
Above 0.50 s: markedly prolonged. (501 ms)
14.ECG rhythm strip interpretation
Answer: torsades de pointes
More ventricular rhythms: torsades de pointes is a polymorphic ventricular tachycardia, usually 150–250/min, in which the wide complexes change in height and twist around the baseline, pointing up for a few beats and then down. Textbooks link it to a prolonged QT interval, and magnesium sulfate is the drug resuscitation guidelines name for it. An idioventricular rhythm is a ventricular escape rhythm: regular, wide QRS (0.12 s or more), no P waves, at 20–40/min (an accelerated idioventricular rhythm runs at 40–100/min). Monomorphic VT has identical wide complexes at more than 100/min. VF is chaotic, without any repeating complex.
Five steps
1. Rate: very fast, the complexes are about 6 small boxes apart (about 250 per minute).
2. Rhythm: fast and roughly regular, but the height and direction of the complexes change in a repeating spindle pattern.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: wide and polymorphic; the complexes twist around the baseline, pointing up for a few beats and then down.
Interpretation
torsades de pointes
Answer
torsades de pointes
Torsades de pointes is a polymorphic VT linked to a prolonged QT interval. This is identification practice only.
15.Prioritization & delegation
Answer: A · Hold the next dose and report it promptly
Why this is the answer
Aminoglycosides can cause ototoxicity, which may be permanent. Tinnitus or hearing loss is reported promptly, and drug levels and kidney function are checked.
Answer
A · Hold the next dose and report it promptly
16.Prioritization & delegation
Answer: D · Defibrillate as soon as the defibrillator is available, with CPR until then
Why this is the answer
Ventricular fibrillation is a shockable cardiac arrest rhythm. Early defibrillation, with high-quality CPR until the shock is given, is the most important treatment.
Answer
D · Defibrillate as soon as the defibrillator is available, with CPR until then