Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Why must anti-embolism stockings be measured and fitted correctly?
ACorrect fit is needed only to improve the appearance
BLoose stockings make the patient's legs too warm at night
CPoorly fitting stockings can cause pressure damage
DTight stockings work better, so the smallest size is always best
2.Med-surg: cardiovascular & respiratoryHard
A patient with lung cancer develops swelling of the face and arms, distended neck and chest veins and breathlessness that is worse when bending forward. What is the most likely cause?
ASuperior vena cava obstruction
BA deep vein thrombosis in the leg
CRight-sided heart failure
DAn allergic reaction to chemotherapy
3.Med-surg: neuro, endocrine & renalMedium
A patient with severe vomiting and diarrhoea takes ramipril, furosemide and metformin. Which advice is correct?
ADouble the furosemide to prevent fluid retention
BKeep taking everything as normal and drink less
CPause these medicines until eating and drinking again
DAdd ibuprofen to treat the abdominal cramps
4.Med-surg: neuro, endocrine & renalHard
A patient with known back pain says they now cannot feel the skin between their legs and have not passed urine for 12 hours. What should happen?
AA laxative and review in the clinic in a month
BUrgent MRI and referral to the spinal surgeons
CA routine physiotherapy appointment next week
DAdvice to rest at home and take stronger painkillers
5.Med-surg: GI, perioperative & oncologyMedium
Which electrolyte abnormality can contribute to a postoperative ileus?
AHypernatraemia
BHyperkalaemia
CHyperphosphataemia
DHypokalaemia
6.Med-surg: GI, perioperative & oncologyHard
On day 3 after a major burn, the patient starts passing large volumes of urine. Which electrolyte problem should the nurse anticipate?
AHypernatraemia, as the kidneys begin to retain sodium
BHypercalcaemia, caused by bed rest and immobilisation
CHypokalaemia, as fluid returns to the circulation
DHyperkalaemia, as new tissue damage releases potassium
7.Clinical nursingMedium
Which oxygen device delivers a precise, fixed concentration of oxygen?
ANasal cannula
BVenturi mask
CSimple face mask
DNon-rebreathe mask
8.Clinical nursingHard
Which route and site are recommended for the first dose of adrenaline (epinephrine) in anaphylaxis on a ward?
AOral tablet dissolved under the tongue
BIntravenous bolus given by the nurse without monitoring
CSubcutaneous injection into the upper arm
DIntramuscular injection into the anterolateral thigh
9.Lab values & electrolytesMedium
A patient takes high-dose biotin supplements for hair and nails. Why should the nurse report this before blood tests?
ABiotin lowers the hemoglobin by destroying the red cells
BBiotin causes a true rise in blood glucose in all patients
CBiotin can distort some immunoassays, such as troponin or TSH
DBiotin makes the blood clot in the tube before testing
10.Lab values & electrolytesHard
A 5-year-old has new bruising and petechiae two weeks after a viral illness. Platelets are 12 × 10³/µL; hemoglobin, white cell count and clotting times are normal. Which condition is most likely?
AHemophilia A
BImmune thrombocytopenia (ITP)
CAcute leukemia
DDisseminated intravascular coagulation
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 23 mmHg (3.1 kPa). Use the rule that in acute respiratory alkalosis HCO₃⁻ falls by 2 mmol/L for every 10 mmHg that PaCO₂ is below 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
A practice gas shows a respiratory acidosis: pH 7.23, PaCO₂ 84 mmHg (11.2 kPa), HCO₃⁻ 34 mmol/L. Use the rules ‘HCO₃⁻ rises 1 mmol/L per 10 mmHg (acute) or 3.5 mmol/L per 10 mmHg (chronic)’ to classify it. Click your answer.
pH 7.23PaCO₂ 84 mmHg (11.2 kPa)HCO₃⁻ 34 mmol/L
1acute
2chronic
3acute on chronic
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1idioventricular rhythm
2torsades de pointes
3atrial flutter, 2:1 conduction
4ventricular fibrillation
15.Prioritization & delegationMedium
A patient with mild dysphagia after a stroke is eating. Which technique helps make swallowing safer?
ADrinking thin fluids quickly through a straw between bites
BTalking while eating to stay alert
CLying flat with the head tilted back
DSitting upright with the chin tucked down while swallowing
16.Prioritization & delegationHard
A patient taking an SSRI is also given tramadol. A few hours later the patient is agitated, sweating and has a fever, jerking muscles and brisk reflexes. What is the most likely cause?
ANeuroleptic malignant syndrome
BSerotonin syndrome
COpioid withdrawal
DAn anxiety attack
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Poorly fitting stockings can cause pressure damage
Why this is the answer
Stockings that are the wrong size or that roll down can act like a tourniquet and cause skin and pressure damage. They are measured to the leg, checked daily, and avoided in significant peripheral arterial disease, severe neuropathy or leg skin damage.
Answer
C · Poorly fitting stockings can cause pressure damage
2.Med-surg: cardiovascular & respiratory
Answer: A · Superior vena cava obstruction
Why this is the answer
A tumour in the mediastinum can compress the superior vena cava, causing swelling of the face, neck and arms, dilated veins on the chest and breathlessness. It is an oncological emergency. The patient is sat upright and given oxygen if hypoxic, and treatment may include a stent, steroids or radiotherapy.
Answer
A · Superior vena cava obstruction
3.Med-surg: neuro, endocrine & renal
Answer: C · Pause these medicines until eating and drinking again
Why this is the answer
During dehydrating illness, ACE inhibitors, diuretics and metformin can worsen AKI or its complications. Sick-day guidance usually advises pausing them until the person is eating and drinking normally, and NSAIDs are avoided.
Answer
C · Pause these medicines until eating and drinking again
4.Med-surg: neuro, endocrine & renal
Answer: B · Urgent MRI and referral to the spinal surgeons
Why this is the answer
Saddle anaesthesia with urinary retention suggests cauda equina syndrome. Delay can lead to permanent bladder, bowel and sexual dysfunction. The patient needs an emergency MRI and surgical decompression if confirmed.
Answer
B · Urgent MRI and referral to the spinal surgeons
5.Med-surg: GI, perioperative & oncology
Answer: D · Hypokalaemia
Why this is the answer
Low potassium impairs smooth muscle contraction and is a common correctable contributor to ileus. Magnesium and other electrolytes are also checked and corrected.
Answer
D · Hypokalaemia
6.Med-surg: GI, perioperative & oncology
Answer: C · Hypokalaemia, as fluid returns to the circulation
Why this is the answer
In the first hours, cell destruction and fluid shifts can raise potassium. After about 48–72 hours, capillary integrity improves, fluid returns to the circulation and diuresis begins, with potassium loss and hypokalaemia. Electrolytes are monitored throughout.
Answer
C · Hypokalaemia, as fluid returns to the circulation
7.Clinical nursing
Answer: B · Venturi mask
Why this is the answer
A Venturi mask entrains a set amount of room air, giving a fixed oxygen percentage regardless of the patient's breathing pattern. This makes it useful for patients at risk of hypercapnia.
Answer
B · Venturi mask
8.Clinical nursing
Answer: D · Intramuscular injection into the anterolateral thigh
Why this is the answer
IM adrenaline into the outer thigh is absorbed quickly and is the first-line route. IV adrenaline is reserved for experienced specialists with full monitoring because of the risk of arrhythmias.
Answer
D · Intramuscular injection into the anterolateral thigh
9.Lab values & electrolytes
Answer: C · Biotin can distort some immunoassays, such as troponin or TSH
Why this is the answer
Many immunoassays use biotin-streptavidin binding, and high blood biotin levels can give falsely high or low results, for example a falsely low troponin or abnormal thyroid tests. The laboratory and prescriber should know about biotin use.Checked against:Troponin Test · MedlinePlus (NIH) (2023); Biotin Interference with Troponin Lab Tests - Assays Subject to Biotin Interference · U.S. FDA (2022)
Answer
C · Biotin can distort some immunoassays, such as troponin or TSH
10.Lab values & electrolytes
Answer: B · Immune thrombocytopenia (ITP)
Why this is the answer
ITP is immune destruction of platelets, often after a viral infection in children. It causes isolated thrombocytopenia with normal other counts and clotting tests. Leukemia usually affects other cell lines, DIC prolongs clotting times and hemophilia prolongs the aPTT.Checked against:Immune thrombocytopenic purpura (ITP) · MedlinePlus (NIH) (2026)
Answer
B · Immune thrombocytopenia (ITP)
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 20.6 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|23 − 40| = 17 mmHg → 1.7 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 − 2·1.7 = 20.6 mmol/L
Answer
HCO₃⁻ = 20.6 mmol/L
12.Arterial blood gas interpretation
Answer: acute on chronic
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected HCO₃⁻
acute: 24 + 1·4.4 = 28.4 mmol/L
chronic: 24 + 3.5·4.4 = 39.4 mmol/L
Compare
measured: 34 mmol/L → acute on chronic
Answer
acute on chronic
13.ECG rhythm strip interpretation
Answer: QTc = 0.47 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 10.5 × 0.04 = 0.42 s
RR = 20 × 0.04 = 0.80 s
Bazett’s formula
QTc = 0.42/√0.80 = 0.42/0.8944 = 0.47 s
Answer
QTc = 0.47 s
Above the usual limits for both men (about 0.45 s) and women (about 0.46 s): prolonged. (470 ms)
14.ECG rhythm strip interpretation
Answer: torsades de pointes
More ventricular rhythms: torsades de pointes is a polymorphic ventricular tachycardia, usually 150–250/min, in which the wide complexes change in height and twist around the baseline, pointing up for a few beats and then down. Textbooks link it to a prolonged QT interval, and magnesium sulfate is the drug resuscitation guidelines name for it. An idioventricular rhythm is a ventricular escape rhythm: regular, wide QRS (0.12 s or more), no P waves, at 20–40/min (an accelerated idioventricular rhythm runs at 40–100/min). Monomorphic VT has identical wide complexes at more than 100/min. VF is chaotic, without any repeating complex.
Five steps
1. Rate: very fast, the complexes are about 7 small boxes apart (about 214 per minute).
2. Rhythm: fast and roughly regular, but the height and direction of the complexes change in a repeating spindle pattern.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: wide and polymorphic; the complexes twist around the baseline, pointing up for a few beats and then down.
Interpretation
torsades de pointes
Answer
torsades de pointes
Torsades de pointes is a polymorphic VT linked to a prolonged QT interval. This is identification practice only.
15.Prioritization & delegation
Answer: D · Sitting upright with the chin tucked down while swallowing
Why this is the answer
Sitting upright and tucking the chin narrows the airway entrance and helps food pass into the esophagus. The nurse follows the speech therapist’s plan, which may include thickened fluids.
Answer
D · Sitting upright with the chin tucked down while swallowing
16.Prioritization & delegation
Answer: B · Serotonin syndrome
Why this is the answer
SSRIs and tramadol both raise serotonin. Agitation, fever, clonus and hyperreflexia that start quickly suggest serotonin syndrome; neuroleptic malignant syndrome follows antipsychotics and causes rigid muscles with slow reflexes.