Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient has central chest pain and a STEMI on the ECG. What does this usually require?
AEmergency reperfusion, preferably by primary PCI
BAdmission and a repeat ECG the next morning
COral beta-blocker and discharge if pain settles
DA troponin result before any treatment decision is made
2.Med-surg: cardiovascular & respiratoryHard
A patient with rheumatoid arthritis is due to start an anti-TNF biologic drug. Which screening is essential beforehand?
AA sweat chloride test
BAn exercise ECG test on a treadmill
CA peak flow diary for a month
DScreening for latent tuberculosis
3.Med-surg: neuro, endocrine & renalMedium
Why are patients on haemodialysis vaccinated against hepatitis B?
AThe vaccine is needed to make the dialyser work
BThe vaccine lowers the potassium level
CHepatitis B vaccine improves the fistula flow
DShared dialysis units carry a higher infection risk
4.Med-surg: neuro, endocrine & renalHard
A patient who had pituitary surgery has fatigue and feels cold. TSH is low, and free T4 is low. What is the most likely cause?
AOver-replacement with levothyroxine
BHyperthyroidism from Graves' disease
CSecondary hypothyroidism
DPrimary hypothyroidism from thyroid failure
5.Med-surg: GI, perioperative & oncologyMedium
Which statement about pain relief in acute pancreatitis is correct?
APain relief should be withheld until the diagnosis is certain
BOnly paracetamol may be given
COpioids can be used, and good analgesia is a priority
DOpioids must never be used in pancreatitis
6.Med-surg: GI, perioperative & oncologyHard
A patient is booked for a urea breath test for H. pylori. Which medicine should usually be stopped 2 weeks before the test?
ALevothyroxine
BParacetamol (acetaminophen)
CAmlodipine
DOmeprazole
7.Clinical nursingMedium
Which is a major risk factor for Clostridioides difficile infection?
ARecent broad-spectrum antibiotic use
BA diet high in fibre and fresh fruit
CTaking regular paracetamol
DRegular exercise
8.Clinical nursingHard
A dying patient has noisy, rattling breathing caused by secretions in the throat and is unconscious. Which approach is appropriate?
AReposition, consider prescribed antisecretory drugs and support the family
BBegin rapid intravenous fluids to thin and clear the secretions
CStart deep oropharyngeal suctioning every 10 minutes through the night
DTell the family that the patient is suffocating and needs ventilation
9.Lab values & electrolytesMedium
A patient has weight loss, tremor and heat intolerance. Which thyroid test pattern fits Graves disease?
ANormal TSH with a low free T4
BHigh TSH with a normal free T4
CHigh TSH with a low free T4
DLow TSH with a high free T4
10.Lab values & electrolytesHard
A patient with C. difficile diarrhea has a white cell count of 24 × 10³/µL and a creatinine that has risen to 2.1 mg/dL (186 µmol/L). What does this indicate?
AUnrelated chronic kidney disease
BMild infection needing no treatment
CSevere C. difficile infection
DSuccessful response to treatment
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 147 mmol/L, glucose 23.1 mmol/L and urea 10 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 147 mmol/Lglucose 23.1 mmol/Lurea 10 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.13, PaCO₂ 44 mmHg (5.9 kPa), HCO₃⁻ 14 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.13PaCO₂ 44 mmHg (5.9 kPa)HCO₃⁻ 14 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus tachycardia
2junctional rhythm
3sinus bradycardia
4first-degree AV block
14.ECG rhythm strip interpretationHard
This patient has a pacemaker. Interpret the lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1third-degree (complete) AV block
2dual-chamber (AV) paced rhythm
3sinus rhythm with wide QRS
4junctional rhythm
15.Prioritization & delegationMedium
Straight after birth, what is the first priority for a healthy-looking newborn?
AGive the vitamin K injection before anything else is done
BWeigh and measure the baby on the scale
CGive the first bath to remove the blood and vernix
DDry and warm the baby while checking that it is breathing
16.Prioritization & delegationHard
Several patients on a unit develop diarrhea within two days. What should the nurse do first?
AWait to see if more patients become unwell
BGive all patients antidiarrheal drugs without assessment
CMove the affected patients into shared rooms with other patients to free up beds
DPlace affected patients on contact precautions and inform infection control
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · Emergency reperfusion, preferably by primary PCI
Why this is the answer
A STEMI usually reflects total occlusion of a coronary artery. Emergency reperfusion, preferably primary PCI (or thrombolysis if PCI cannot be done in time), is needed as soon as possible; "time is muscle". The decision is made on the ECG and symptoms, not on the troponin result.
Answer
A · Emergency reperfusion, preferably by primary PCI
2.Med-surg: cardiovascular & respiratory
Answer: D · Screening for latent tuberculosis
Why this is the answer
TNF-alpha is essential for containing TB in granulomas. Anti-TNF drugs can reactivate latent TB, sometimes as severe disseminated disease. Patients are screened (history, chest X-ray, IGRA) and treated for latent TB before starting.
Answer
D · Screening for latent tuberculosis
3.Med-surg: neuro, endocrine & renal
Answer: D · Shared dialysis units carry a higher infection risk
Why this is the answer
Haemodialysis involves repeated vascular access in a shared unit, which raises the risk of blood-borne infection. Vaccination, screening and strict infection control protect patients and staff.
Answer
D · Shared dialysis units carry a higher infection risk
4.Med-surg: neuro, endocrine & renal
Answer: C · Secondary hypothyroidism
Why this is the answer
When the pituitary cannot make enough TSH, the thyroid is not stimulated, so both TSH and free T4 are low. In primary thyroid failure, TSH is high. In secondary hypothyroidism, free T4, not TSH, is used to guide the dose.
Answer
C · Secondary hypothyroidism
5.Med-surg: GI, perioperative & oncology
Answer: C · Opioids can be used, and good analgesia is a priority
Why this is the answer
Acute pancreatitis is very painful, and opioids are used as part of multimodal analgesia. There is no good evidence that they worsen the condition. Sedation and breathing are monitored.
Answer
C · Opioids can be used, and good analgesia is a priority
6.Med-surg: GI, perioperative & oncology
Answer: D · Omeprazole
Why this is the answer
PPIs suppress H. pylori and can give false-negative breath or stool tests, so they are usually stopped 2 weeks before. Antibiotics are usually stopped 4 weeks before testing.
Answer
D · Omeprazole
7.Clinical nursing
Answer: A · Recent broad-spectrum antibiotic use
Why this is the answer
Broad-spectrum antibiotics disrupt normal gut flora, letting C. difficile overgrow. Older age, hospital stay and proton pump inhibitors also increase the risk.
Answer
A · Recent broad-spectrum antibiotic use
8.Clinical nursing
Answer: A · Reposition, consider prescribed antisecretory drugs and support the family
Why this is the answer
The "death rattle" is managed by repositioning, mouth care and sometimes drugs that reduce secretions. Explaining it to relatives eases their distress.
Answer
A · Reposition, consider prescribed antisecretory drugs and support the family
9.Lab values & electrolytes
Answer: D · Low TSH with a high free T4
Why this is the answer
In Graves disease, antibodies stimulate the thyroid to make too much hormone. The high free T4 suppresses TSH from the pituitary through negative feedback, so TSH is low. A high TSH with a low T4 fits primary hypothyroidism.Checked against:TSH test · MedlinePlus (NIH) (2026); Thyroxine (T4) Test · MedlinePlus (NIH) (2024); Graves disease · MedlinePlus (NIH) (2026)
Answer
D · Low TSH with a high free T4
10.Lab values & electrolytes
Answer: C · Severe C. difficile infection
Why this is the answer
A white count of 15 × 10³/µL or more or a creatinine above 1.5 mg/dL marks severe C. difficile infection. These patients need prompt treatment, fluid replacement and close monitoring for complications such as toxic megacolon. Contact precautions with soap-and-water hand hygiene are used.
Answer
C · Severe C. difficile infection
11.Arterial blood gas interpretation
Answer: Osm = 327 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·147 + 23.1 + 10 = 327.1 ≈ 327 mOsm/kg
Answer
Osm = 327 mOsm/kg
12.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·14 + 8 = 29 → 27–31 mmHg
Compare
measured: 44 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
13.ECG rhythm strip interpretation
Answer: sinus bradycardia
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 35 small boxes, 1500 ÷ 35 ≈ 43 per minute.
2. Rhythm: regular, every R–R is 1.40 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.20 s, constant, within 0.12–0.20 s.
5. QRS: 0.06 s, narrow (below 0.12 s).
Interpretation
sinus bradycardia
Answer
sinus bradycardia
14.ECG rhythm strip interpretation
Answer: dual-chamber (AV) paced rhythm
Paced rhythms: a pacemaker impulse shows as a narrow vertical pacing spike. After a ventricular spike the QRS is wide (0.12 s or more), because the impulse spreads from the lead through the muscle instead of the conduction system; with right-ventricular pacing it is often mostly negative in lead II. A spike before each P wave means atrial pacing, and a dual-chamber (AV) pacemaker shows an atrial spike and a P wave, then, after the programmed AV delay, a ventricular spike and a wide QRS. Capture means every spike is followed by a depolarisation. Failure to capture is a spike without a P wave or QRS after it; failure to sense (spikes that ignore the patient’s own beats) and failure to pace (no spike when one is due) are the other classic malfunctions.
Five steps
1. Rate: R–R = 24 small boxes, 1500 ÷ 24 ≈ 63 per minute.
2. Rhythm: regular, every R–R is 0.96 s.
3. P waves: each P wave follows its own pacing spike (atrial pacing).
4. AV interval: the second spike comes 0.20 s after the first one (the programmed AV delay).
5. QRS: 0.16 s, wide, right after the second spike (ventricular pacing).
Interpretation
dual-chamber (AV) paced rhythm
Answer
dual-chamber (AV) paced rhythm
The paced QRS is wide by nature; do not call it a bundle branch block or a ventricular rhythm.
15.Prioritization & delegation
Answer: D · Dry and warm the baby while checking that it is breathing
Why this is the answer
Breathing and keeping warm come first. Drying stimulates breathing and reduces heat loss; skin-to-skin contact helps. Weighing and routine injections can wait.
Answer
D · Dry and warm the baby while checking that it is breathing
16.Prioritization & delegation
Answer: D · Place affected patients on contact precautions and inform infection control
Why this is the answer
A cluster of diarrhea may be an outbreak, for example of C. difficile or norovirus. Contact precautions and early notification of infection control limit spread.
Answer
D · Place affected patients on contact precautions and inform infection control