Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Why are beta-blockers often started after a myocardial infarction?
AThey raise the heart rate to improve blood flow to the muscle
BThey dissolve the clot that is blocking the coronary artery
CThey reduce cholesterol in the blood
DThey lower the heart's oxygen demand and reduce arrhythmias
2.Med-surg: cardiovascular & respiratoryHard
A patient with a confirmed pulmonary embolism has BP 78/50 mmHg despite fluids, and the right ventricle is dilated on echocardiography. Which treatment is most likely?
AOral apixaban only, started next week
BSystemic thrombolysis
CCompression stockings and bed rest
DAn inhaled bronchodilator
3.Med-surg: neuro, endocrine & renalMedium
A nurse is teaching a patient going home after a mild concussion. Which statement shows a need for further teaching?
A"I will come back if I start vomiting again and again."
B"Someone will stay with me for the first night."
C"I will return if my headache gets steadily worse."
D"A few drinks tonight will help me relax and sleep."
4.Med-surg: neuro, endocrine & renalHard
A patient with stable epilepsy on phenytoin started a new medicine last week. They now have nystagmus, an unsteady gait and slurred speech. What should the nurse do?
AEncourage the patient to walk more to improve their balance
BSuspect phenytoin toxicity, hold the next dose and ask for a drug level
CSuspect a new stroke and give aspirin straight away before any scan
DGive the next phenytoin dose early to prevent a seizure
5.Med-surg: GI, perioperative & oncologyMedium
A patient with a new colostomy asks what to eat at home. Which advice is most appropriate?
AEat a normal, balanced diet and introduce foods gradually
BAvoid all fruit and vegetables for the rest of their life
CEat only liquids until the stoma is removed
DDrink as little fluid as possible to reduce output
6.Med-surg: GI, perioperative & oncologyHard
During preoperative assessment, a patient says their brother had a "very high fever" during an anaesthetic. What is the most important action?
AReassure the patient that fevers after anaesthesia are always harmless
BGive paracetamol before surgery to prevent fever
CRecord it as a family allergy to paracetamol
DInform the anaesthetist, as malignant hyperthermia may run in the family
7.Clinical nursingMedium
What should a patient starting oral iron tablets be told?
ATheir stools may turn dark or black
BThey must take the tablets with strong tea
CTheir urine will turn bright green
DThe tablets will cause weight loss
8.Clinical nursingHard
Why must severe chronic hyponatraemia be corrected slowly?
AToo-rapid correction can cause osmotic demyelination in the brain
BFast correction makes the kidneys stop producing urine
CSodium given quickly causes immediate cardiac arrest
DFast correction causes severe hypoglycaemia and seizures in most patients
9.Lab values & electrolytesMedium
An older adult takes lisinopril and furosemide and recently started daily ibuprofen for knee pain. The creatinine has risen from 1.0 to 1.8 mg/dL (88 to 159 µmol/L). What is the most likely cause?
ANormal aging of the kidneys over a period of a few weeks
BA laboratory error, since ibuprofen has no effect on the kidney
CMore activity has increased the patient's muscle mass quickly
DThe NSAID reduces kidney blood flow on top of the other two drugs
10.Lab values & electrolytesHard
A patient has sudden episodes of severe headache, sweating, palpitations and very high blood pressure. Which test is most useful to look for the cause?
APlasma free metanephrines
BFasting lipid profile
CSerum calcium only
DSerum TSH and free T4
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 16 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 16 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 141, Cl⁻ 94 and HCO₃⁻ 16 mmol/L. Calculate the delta ratio (AG − 12)/(24 − HCO₃⁻), using AG = Na⁺ − (Cl⁻ + HCO₃⁻). Give two decimals.
Na⁺ 141 mmol/LCl⁻ 94 mmol/LHCO₃⁻ 16 mmol/L
delta ratio =
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1second-degree AV block type II
2second-degree AV block type I (Wenckebach)
3first-degree AV block
4third-degree (complete) AV block
15.Prioritization & delegationMedium
A pregnant nurse is on the unit. Which patient should the charge nurse avoid assigning to her?
AA patient with type 2 diabetes who needs insulin teaching before discharge
BA patient with a sealed radioactive implant for cervical cancer
CA patient with a fractured wrist
DA patient after a hip replacement
16.Prioritization & delegationHard
A trauma patient has an open leg fracture, absent breath sounds on one side, a trachea shifted to the other side and a falling blood pressure. Which problem is the priority?
AThe pain from the fracture
BThe risk of wound infection
CThe suspected tension pneumothorax
DThe open fracture of the leg
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · They lower the heart's oxygen demand and reduce arrhythmias
Why this is the answer
Beta-blockers slow the heart and reduce contractility, lowering myocardial oxygen demand, and protect against arrhythmias. They are particularly beneficial when the ejection fraction is reduced. They are used cautiously in heart block, severe bradycardia, acute heart failure and asthma.
Answer
D · They lower the heart's oxygen demand and reduce arrhythmias
2.Med-surg: cardiovascular & respiratory
Answer: B · Systemic thrombolysis
Why this is the answer
A PE causing sustained hypotension is high-risk and usually treated with thrombolysis to dissolve the clot quickly, unless contraindicated, when surgical or catheter removal may be used. Stable patients are usually treated with anticoagulation alone.
Answer
B · Systemic thrombolysis
3.Med-surg: neuro, endocrine & renal
Answer: D · "A few drinks tonight will help me relax and sleep."
Why this is the answer
After a head injury, alcohol and sedatives should be avoided because they can mask drowsiness and confusion. A responsible adult should stay with the patient, and worsening headache, repeated vomiting, confusion or drowsiness mean they must return.
Answer
D · "A few drinks tonight will help me relax and sleep."
4.Med-surg: neuro, endocrine & renal
Answer: B · Suspect phenytoin toxicity, hold the next dose and ask for a drug level
Why this is the answer
Nystagmus, ataxia and slurred speech are classic signs of phenytoin toxicity. Interacting drugs can raise its level. The nurse holds the dose, ensures safety and escalates for a level and a review. A new neurological deficit still needs medical assessment.
Answer
B · Suspect phenytoin toxicity, hold the next dose and ask for a drug level
5.Med-surg: GI, perioperative & oncology
Answer: A · Eat a normal, balanced diet and introduce foods gradually
Why this is the answer
People with a colostomy can usually eat a normal diet. Foods are reintroduced gradually to see how each one affects gas, odour and output, and regular meals and fluids help.
Answer
A · Eat a normal, balanced diet and introduce foods gradually
6.Med-surg: GI, perioperative & oncology
Answer: D · Inform the anaesthetist, as malignant hyperthermia may run in the family
Why this is the answer
Malignant hyperthermia susceptibility is inherited. The anaesthetist plans a trigger-free anaesthetic, avoiding volatile agents and suxamethonium, and the family may be referred for testing.
Answer
D · Inform the anaesthetist, as malignant hyperthermia may run in the family
7.Clinical nursing
Answer: A · Their stools may turn dark or black
Why this is the answer
Oral iron commonly darkens the stool and can cause constipation or stomach upset. Tea and antacids reduce absorption, while vitamin C may increase it.
Answer
A · Their stools may turn dark or black
8.Clinical nursing
Answer: A · Too-rapid correction can cause osmotic demyelination in the brain
Why this is the answer
In chronic hyponatraemia brain cells adapt to the low tonicity. A rapid rise in sodium draws water out too fast and can cause osmotic demyelination, so the correction rate is limited and sodium is checked often.
Answer
A · Too-rapid correction can cause osmotic demyelination in the brain
9.Lab values & electrolytes
Answer: D · The NSAID reduces kidney blood flow on top of the other two drugs
Why this is the answer
NSAIDs reduce prostaglandin-driven blood flow to the kidney. Combined with an ACE inhibitor and a diuretic, this can cause acute kidney injury, especially in older adults. The nurse reports the result and the NSAID is usually stopped.
Answer
D · The NSAID reduces kidney blood flow on top of the other two drugs
10.Lab values & electrolytes
Answer: A · Plasma free metanephrines
Why this is the answer
These episodes suggest pheochromocytoma, a tumor of the adrenal medulla that releases catecholamines. Plasma free metanephrines (or 24-hour urine metanephrines) are the main screening tests. Hyperthyroidism can cause similar symptoms but usually without these bursts of severe hypertension.
Answer
A · Plasma free metanephrines
11.Arterial blood gas interpretation
Answer: PaCO₂ = 32 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·16 + 8 = 32 mmHg
range: 30–34 mmHg
Answer
PaCO₂ = 32 mmHg
12.Arterial blood gas interpretation
Answer: delta ratio = 2.375
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 141 − (94 + 16) = 31
Delta ratio
(31 − 12)/(24 − 16) = 19/8 = 2.375
Answer
delta ratio = 2.375
Above 2: an added metabolic alkalosis.
13.ECG rhythm strip interpretation
Answer: QTc = 0.438 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 10 × 0.04 = 0.40 s
RR = 19 × 0.04 = 0.76 s
Fridericia’s formula
QTc = 0.40/∛0.76 = 0.40/0.9126 = 0.438 s
Answer
QTc = 0.438 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (438 ms)
14.ECG rhythm strip interpretation
Answer: second-degree AV block type I (Wenckebach)
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: 5 QRS complexes in 6 s, × 10 = 50 per minute.
2. Rhythm: regularly irregular, the QRS complexes come in groups separated by a pause (group beating).
3. P waves: upright and regular (P–P 0.88 s, 68 per minute); one P in every 4 is not followed by a QRS.
4. PR interval: lengthens 0.18 → 0.30 → 0.38 s, then a P wave is not conducted.
5. QRS: 0.10 s, narrow (below 0.12 s).
Interpretation
second-degree AV block type I (Wenckebach)
Answer
second-degree AV block type I (Wenckebach)
15.Prioritization & delegation
Answer: B · A patient with a sealed radioactive implant for cervical cancer
Why this is the answer
A sealed radioactive implant (brachytherapy) emits radiation, and pregnant staff should not care for these patients. The other patients pose no special risk to a pregnancy.
Answer
B · A patient with a sealed radioactive implant for cervical cancer
16.Prioritization & delegation
Answer: C · The suspected tension pneumothorax
Why this is the answer
A shifted trachea, absent breath sounds and hypotension suggest tension pneumothorax, which threatens breathing and circulation within minutes. The fracture is important, but it comes after the immediate life threat.