Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient on ramipril is to start sacubitril/valsartan for heart failure. What is the key safety point?
AThe ACE inhibitor dose should be doubled during the change
BSacubitril/valsartan is safe to start on the same morning
CThe ACE inhibitor must be stopped first, with a gap before starting
DBoth drugs should be taken together each day for the best effect
2.Med-surg: cardiovascular & respiratoryHard
A nurse reviews inhaler use with a patient who has asthma and uses a separate steroid preventer inhaler and a salbutamol reliever. Which statement shows a need for further teaching?
A"I rinse my mouth after the steroid inhaler."
B"I carry my blue reliever inhaler with me."
C"I use my steroid inhaler when I start to wheeze."
D"I use my steroid inhaler every day, even when I feel well."
3.Med-surg: neuro, endocrine & renalMedium
Why are insulin and glucose given together to treat hyperkalaemia?
AInsulin moves potassium into cells; glucose prevents a hypo
BInsulin makes the kidneys pass more potassium in the urine
CGlucose binds the potassium in the blood and removes it
DInsulin protects the heart muscle cells from the potassium
4.Med-surg: neuro, endocrine & renalHard
A patient with motor neurone disease reports morning headaches, poor sleep and sleepiness during the day. What do these symptoms suggest?
ANormal tiredness that needs no specific action
BLow mood, which should be treated with an antidepressant first
CA side effect of riluzole, which should be stopped straight away by the nurse
DWeak breathing at night, so a review for ventilation support
5.Med-surg: GI, perioperative & oncologyMedium
Why do patients with major burns lose so much fluid in the first 24–48 hours?
ALeaky capillaries let plasma move into the tissues
BThe burned skin absorbs fluid from the air
CThe kidneys stop making urine completely
DPatients drink far too little in hospital in the first days
6.Med-surg: GI, perioperative & oncologyHard
A surgical patient's MUST score is 3 and the wound is healing slowly. What is the most appropriate action?
ARepeat the score in three months' time
BRefer to the dietitian, start a nutrition plan and monitor intake
CEncourage fasting to reduce wound exudate and the size of the dressing
DRestrict protein to help the kidneys
7.Clinical nursingMedium
Why can a very low serum albumin contribute to oedema?
AIt lowers the oncotic pressure that holds fluid in the blood vessels
BIt makes the kidneys retain potassium
CIt increases the number of red cells
DIt raises the blood pressure in the capillaries and pushes fluid out
8.Clinical nursingHard
Which patient should the nurse assess first?
AA patient with asthma who can only speak in single words
BA patient with COPD whose SpO2 is 89% and within their target range
CA patient with diabetes whose glucose is 11 mmol/L (198 mg/dL) before lunch
DA postoperative patient who rates their pain as 6/10
9.Lab values & electrolytesMedium
How does normal pregnancy usually affect serum creatinine?
AIt falls, because GFR rises
BIt rises, because GFR falls
CIt rises with every week
DIt stays exactly the same
10.Lab values & electrolytesHard
A patient with sepsis has the following new results. Which set best shows organ dysfunction?
A practice gas shows a metabolic acidosis with HCO₃⁻ 16 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 16 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.26, PaCO₂ 23 mmHg (3.1 kPa), HCO₃⁻ 10 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.26PaCO₂ 23 mmHg (3.1 kPa)HCO₃⁻ 10 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1second-degree AV block type II
2sinus bradycardia
3third-degree (complete) AV block
4first-degree AV block
15.Prioritization & delegationMedium
During labor, the nurse sees the umbilical cord in the vagina after the membranes rupture. What is the first action?
ARelieve pressure on the cord by lifting the presenting part with a gloved hand
BWait for the next contraction before acting
CPush the cord back into the uterus
DAsk the patient to walk around the room to bring the baby lower and speed up labor
16.Prioritization & delegationHard
A nursing assistant measured vital signs 15 minutes after a patient’s first dose of morphine. They report a respiratory rate of 10/min and say the patient is hard to wake. What should the nurse do?
AGo at once, rouse the patient, support breathing and prepare naloxone per order
BAsk the assistant to recheck the respiratory rate in 15 minutes and report back
CDocument the findings and tell the provider at the next scheduled round
DPhone the provider for orders before going to see the patient
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · The ACE inhibitor must be stopped first, with a gap before starting
Why this is the answer
Combining an ACE inhibitor with sacubitril/valsartan greatly increases the risk of angioedema. The ACE inhibitor is stopped and a washout period (usually 36 hours) is observed before starting. Blood pressure, potassium and renal function are monitored.
Answer
C · The ACE inhibitor must be stopped first, with a gap before starting
2.Med-surg: cardiovascular & respiratory
Answer: C · "I use my steroid inhaler when I start to wheeze."
Why this is the answer
Inhaled corticosteroids are preventers that reduce airway inflammation over days to weeks and must be taken regularly. They do not relieve an acute wheeze. Unless the patient has a combined reliever and maintenance regimen, a short-acting bronchodilator is used for symptoms.
Answer
C · "I use my steroid inhaler when I start to wheeze."
3.Med-surg: neuro, endocrine & renal
Answer: A · Insulin moves potassium into cells; glucose prevents a hypo
Why this is the answer
Insulin activates the sodium–potassium pump, moving potassium into cells and lowering the serum level within about 15–30 minutes. Glucose is given to prevent hypoglycaemia. The effect is temporary, so potassium must also be removed.
Answer
A · Insulin moves potassium into cells; glucose prevents a hypo
4.Med-surg: neuro, endocrine & renal
Answer: D · Weak breathing at night, so a review for ventilation support
Why this is the answer
Weak respiratory muscles cause nocturnal hypoventilation and a rise in CO2, leading to morning headaches, disturbed sleep and daytime drowsiness. Non-invasive ventilation can improve symptoms and survival, in line with the patient's wishes.
Answer
D · Weak breathing at night, so a review for ventilation support
5.Med-surg: GI, perioperative & oncology
Answer: A · Leaky capillaries let plasma move into the tissues
Why this is the answer
Inflammatory mediators make capillaries leaky, so plasma moves into the tissues and from the burn surface. Without fluids this causes burn shock; oedema is greatest in the first day or two.
Answer
A · Leaky capillaries let plasma move into the tissues
6.Med-surg: GI, perioperative & oncology
Answer: B · Refer to the dietitian, start a nutrition plan and monitor intake
Why this is the answer
A MUST score of 2 or more indicates high risk of malnutrition. Poor nutrition delays healing, so the nurse refers to the dietitian, starts a care plan with food charts and supplements as advised, and rescreens regularly.
Answer
B · Refer to the dietitian, start a nutrition plan and monitor intake
7.Clinical nursing
Answer: A · It lowers the oncotic pressure that holds fluid in the blood vessels
Why this is the answer
Albumin creates oncotic pressure, drawing fluid into the capillaries. When it is low, as in liver disease, nephrotic syndrome or malnutrition, fluid leaks into the tissues.
Answer
A · It lowers the oncotic pressure that holds fluid in the blood vessels
8.Clinical nursing
Answer: A · A patient with asthma who can only speak in single words
Why this is the answer
Being unable to complete sentences is a sign of acute severe or life-threatening asthma, an airway and breathing emergency. The other patients need attention but are not immediately life-threatened.
Answer
A · A patient with asthma who can only speak in single words
9.Lab values & electrolytes
Answer: A · It falls, because GFR rises
Why this is the answer
In pregnancy, kidney blood flow and GFR rise by about 50%, so creatinine falls below non-pregnant values. A creatinine that looks "normal" for a non-pregnant adult may indicate reduced kidney function in pregnancy.
In sepsis, falling platelets (coagulation), a rising creatinine (kidney) and a raised bilirubin (liver) show organ dysfunction, which indicates severe disease. The other sets are normal or near normal.Checked against:Bacterial Sepsis · StatPearls (NCBI Bookshelf) (2023); Laboratory Evaluation of Sepsis · StatPearls (NCBI Bookshelf) (2023)
Answer
B · Platelets 70 × 10³/µL, creatinine doubled, bilirubin raised
11.Arterial blood gas interpretation
Answer: PaCO₂ = 32 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·16 + 8 = 32 mmHg
range: 30–34 mmHg
Answer
PaCO₂ = 32 mmHg
12.Arterial blood gas interpretation
Answer: appropriate compensation
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·10 + 8 = 23 → 21–25 mmHg
Compare
measured: 23 mmHg → appropriate compensation
Answer
appropriate compensation
13.ECG rhythm strip interpretation
Answer: QTc = 0.377 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 8 × 0.04 = 0.32 s
RR = 18 × 0.04 = 0.72 s
Bazett’s formula
QTc = 0.32/√0.72 = 0.32/0.8485 = 0.377 s
Answer
QTc = 0.377 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (377 ms)
14.ECG rhythm strip interpretation
Answer: second-degree AV block type II
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: 6 QRS complexes in 6 s, × 10 = 60 per minute.
2. Rhythm: the P waves are regular; R–R is regular except for a long pause where a QRS is missing.
3. P waves: upright and regular (P–P 0.76 s, 79 per minute); one P in every 4 is not followed by a QRS.
4. PR interval: constant at 0.16 s in the conducted beats.
5. QRS: 0.12 s, wide (0.12 s or more).
Interpretation
second-degree AV block type II
Answer
second-degree AV block type II
Type II and third-degree blocks are the ones that can suddenly progress, so textbooks rank them as more serious than type I.
15.Prioritization & delegation
Answer: A · Relieve pressure on the cord by lifting the presenting part with a gloved hand
Why this is the answer
In cord prolapse, the presenting part can compress the cord and cut off fetal oxygen. The nurse lifts the presenting part off the cord, calls for help and positions the patient (for example knee-chest) while urgent birth is arranged.
Answer
A · Relieve pressure on the cord by lifting the presenting part with a gloved hand
16.Prioritization & delegation
Answer: A · Go at once, rouse the patient, support breathing and prepare naloxone per order
Why this is the answer
Slow breathing and difficulty rousing suggest opioid-induced respiratory depression. The nurse assesses the patient straight away, stimulates them, supports breathing, gives naloxone per order and escalates. Waiting or calling without seeing the patient wastes critical minutes.
Answer
A · Go at once, rouse the patient, support breathing and prepare naloxone per order