Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Why are beta-blockers often started after a myocardial infarction?
AThey dissolve the clot that is blocking the coronary artery
BThey lower the heart's oxygen demand and reduce arrhythmias
CThey raise the heart rate to improve blood flow to the muscle
DThey reduce cholesterol in the blood
2.Med-surg: cardiovascular & respiratoryHard
Seconds after an intramuscular injection, a patient becomes pale, sweaty and faint, with a heart rate of 48/min. There is no rash, wheeze or swelling, and they recover quickly when laid flat. What is the most likely cause?
AA myocardial infarction
BA vasovagal reaction
CA tension pneumothorax
DAnaphylaxis
3.Med-surg: neuro, endocrine & renalMedium
For which patient would the nurse question an order for pioglitazone?
AA patient with hypothyroidism
BA patient with an allergy to latex
CA patient with heart failure
DA patient with asthma
4.Med-surg: neuro, endocrine & renalHard
A patient recovering from acute tubular necrosis enters the polyuric phase, passing over 4 L of urine a day. What is the main nursing concern?
ARetention of urine in a distended bladder
BHypoglycaemia caused by excess insulin
CFluid overload with high potassium levels
DDehydration with low potassium and sodium
5.Med-surg: GI, perioperative & oncologyMedium
What is the most important safety point about misoprostol?
AIt causes severe constipation in most patients
BIt strongly raises blood glucose in people with diabetes
CIt can cause miscarriage and must not be used in pregnancy
DIt must be given only by deep intramuscular injection
6.Med-surg: GI, perioperative & oncologyHard
A patient taking IV antibiotics has three unexplained loose stools in 24 hours. What should the nurse do first?
AWait two days to see if the diarrhoea settles
BGive loperamide after each loose stool and continue as usual
CIsolate the patient and send a stool sample for testing
DMove the patient to a bay with other patients to watch them closely
7.Clinical nursingMedium
Why is oxygen often humidified for a patient with a tracheostomy?
ADry oxygen causes high blood glucose
BHumidity is needed for the oxygen to work as a drug
CThe tube bypasses the nose, which normally warms and moistens air
DHumidification lowers the oxygen concentration to a safer level
8.Clinical nursingHard
A patient is admitted with suspected meningococcal disease. Which infection control measure is usually needed?
AIsolation only after the patient has gone home
BNo precautions, because it is not contagious
CAirborne precautions with a negative-pressure room for the whole hospital stay
DDroplet precautions until 24 hours of effective antibiotics have been given
9.Lab values & electrolytesMedium
A patient who has been vomiting for two days has a BUN of 32 mg/dL (urea 11.4 mmol/L) and a normal creatinine. What is the most likely cause?
ALow-protein diet
BOverhydration
CDehydration
DLiver failure
10.Lab values & electrolytesHard
During an IV magnesium sulfate infusion, which assessment best detects toxicity early?
ABlood glucose and pupil size every hour
BKnee reflexes, respiratory rate and urine output
CSkin color and capillary refill every hour
DBowel sounds and abdominal girth
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 141 mmol/L, glucose 24 mmol/L and urea 5.1 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 141 mmol/Lglucose 24 mmol/Lurea 5.1 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 144, Cl⁻ 107, HCO₃⁻ 17 mmol/L and albumin 32 g/L. Find the albumin-corrected anion gap AGc = AG + 0.25·(40 − albumin).
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1ventricular fibrillation
2torsades de pointes
3supraventricular tachycardia (SVT)
4idioventricular rhythm
15.Prioritization & delegationMedium
On a postpartum unit, which patient is the most appropriate to assign to an LPN/LVN?
AOne hour after birth with heavy bleeding and a boggy uterus
BSevere pre-eclampsia on a magnesium sulfate infusion
CDay 1 after an uncomplicated vaginal birth, stable vital signs
DA new admission transferred from the labor ward with a fever of 38.6 °C
16.Prioritization & delegationHard
A patient has central chest pain that started 30 minutes ago at rest and has not eased with rest or nitroglycerin. What does this suggest?
AA possible myocardial infarction that needs urgent action
BIndigestion that is best treated with an antacid and a glass of milk
CStable angina that will pass without treatment
DMuscle strain that needs a warm compress
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · They lower the heart's oxygen demand and reduce arrhythmias
Why this is the answer
Beta-blockers slow the heart and reduce contractility, lowering myocardial oxygen demand, and protect against arrhythmias. They are particularly beneficial when the ejection fraction is reduced. They are used cautiously in heart block, severe bradycardia, acute heart failure and asthma.
Answer
B · They lower the heart's oxygen demand and reduce arrhythmias
2.Med-surg: cardiovascular & respiratory
Answer: B · A vasovagal reaction
Why this is the answer
Vasovagal reactions cause bradycardia, pallor, sweating and fainting, and resolve quickly when lying flat. Anaphylaxis usually causes tachycardia, airway or breathing problems and often skin changes, and does not settle on its own. If in doubt, treat as anaphylaxis.
Answer
B · A vasovagal reaction
3.Med-surg: neuro, endocrine & renal
Answer: C · A patient with heart failure
Why this is the answer
Pioglitazone can cause fluid retention and oedema, which can worsen heart failure. It is contraindicated in patients with heart failure. Weight gain and an increased fracture risk are other effects.
Answer
C · A patient with heart failure
4.Med-surg: neuro, endocrine & renal
Answer: D · Dehydration with low potassium and sodium
Why this is the answer
In the diuretic phase of ATN, filtration recovers before tubular reabsorption, so large volumes of dilute urine are passed. Patients risk hypovolaemia and losses of potassium and sodium. Fluid balance, daily weight and electrolytes are monitored and fluids replaced as prescribed.
Answer
D · Dehydration with low potassium and sodium
5.Med-surg: GI, perioperative & oncology
Answer: C · It can cause miscarriage and must not be used in pregnancy
Why this is the answer
Misoprostol protects the stomach lining against NSAID damage, but it stimulates uterine contraction and can cause miscarriage. Diarrhoea is its most common side effect.
Answer
C · It can cause miscarriage and must not be used in pregnancy
6.Med-surg: GI, perioperative & oncology
Answer: C · Isolate the patient and send a stool sample for testing
Why this is the answer
Unexplained diarrhoea in a patient on antibiotics should be treated as possible C. difficile. The patient is isolated promptly, a stool sample is sent and the antibiotics are reviewed with the medical team.
Answer
C · Isolate the patient and send a stool sample for testing
7.Clinical nursing
Answer: C · The tube bypasses the nose, which normally warms and moistens air
Why this is the answer
The upper airway normally humidifies inspired air. Without it, secretions become thick and may block the tracheostomy tube, so humidification is used.
Answer
C · The tube bypasses the nose, which normally warms and moistens air
8.Clinical nursing
Answer: D · Droplet precautions until 24 hours of effective antibiotics have been given
Why this is the answer
Neisseria meningitidis spreads through droplets and close contact. Droplet precautions are used until 24 hours of effective antibiotics, and public health arranges prophylaxis for close contacts.
Answer
D · Droplet precautions until 24 hours of effective antibiotics have been given
9.Lab values & electrolytes
Answer: C · Dehydration
Why this is the answer
When the body is short of fluid, the kidneys reabsorb more urea, so the BUN rises out of proportion to creatinine (a BUN-to-creatinine ratio above 20:1). Liver failure and a low-protein diet lower the BUN.Checked against:BUN (Blood Urea Nitrogen) · MedlinePlus (NIH) (2024)
Answer
C · Dehydration
10.Lab values & electrolytes
Answer: B · Knee reflexes, respiratory rate and urine output
Why this is the answer
Loss of the knee reflex is an early warning sign of magnesium toxicity and appears before slowed breathing. Magnesium is cleared by the kidneys, so falling urine output increases the risk. IV calcium gluconate counteracts magnesium toxicity.Checked against:Magnesium Toxicity · StatPearls (NCBI Bookshelf) (2026); Magnesium Toxicity · StatPearls (NCBI Bookshelf)
Answer
B · Knee reflexes, respiratory rate and urine output
11.Arterial blood gas interpretation
Answer: Osm = 311 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·141 + 24 + 5.1 = 311.1 ≈ 311 mOsm/kg
Answer
Osm = 311 mOsm/kg
12.Arterial blood gas interpretation
Answer: AGc = 22 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 144 − (107 + 17) = 20
Correction for albumin
20 + 0.25·(40 − 32) = 22 mmol/L
Answer
AGc = 22 mmol/L
Above about 12 after correction: a high anion gap.
13.ECG rhythm strip interpretation
Answer: QTc = 0.413 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9 × 0.04 = 0.36 s
RR = 19 × 0.04 = 0.76 s
Bazett’s formula
QTc = 0.36/√0.76 = 0.36/0.8718 = 0.413 s
Answer
QTc = 0.413 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (413 ms)
14.ECG rhythm strip interpretation
Answer: torsades de pointes
More ventricular rhythms: torsades de pointes is a polymorphic ventricular tachycardia, usually 150–250/min, in which the wide complexes change in height and twist around the baseline, pointing up for a few beats and then down. Textbooks link it to a prolonged QT interval, and magnesium sulfate is the drug resuscitation guidelines name for it. An idioventricular rhythm is a ventricular escape rhythm: regular, wide QRS (0.12 s or more), no P waves, at 20–40/min (an accelerated idioventricular rhythm runs at 40–100/min). Monomorphic VT has identical wide complexes at more than 100/min. VF is chaotic, without any repeating complex.
Five steps
1. Rate: very fast, the complexes are about 6 small boxes apart (about 250 per minute).
2. Rhythm: fast and roughly regular, but the height and direction of the complexes change in a repeating spindle pattern.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: wide and polymorphic; the complexes twist around the baseline, pointing up for a few beats and then down.
Interpretation
torsades de pointes
Answer
torsades de pointes
Torsades de pointes is a polymorphic VT linked to a prolonged QT interval. This is identification practice only.
15.Prioritization & delegation
Answer: C · Day 1 after an uncomplicated vaginal birth, stable vital signs
Why this is the answer
A stable patient after an uncomplicated birth fits the LPN/LVN role. Heavy bleeding, magnesium infusions and new admissions with fever need RN assessment.
Answer
C · Day 1 after an uncomplicated vaginal birth, stable vital signs
16.Prioritization & delegation
Answer: A · A possible myocardial infarction that needs urgent action
Why this is the answer
Chest pain that lasts and is not relieved by rest or nitroglycerin suggests acute coronary syndrome, possibly a heart attack. The nurse acts at once: ECG, escalation and prescribed treatment.
Answer
A · A possible myocardial infarction that needs urgent action