Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A pulse oximeter on a patient's finger gives an unreliable, flickering reading. Which factor is the most likely cause?
AThe patient sitting upright in a chair
BCold hands with poor peripheral circulation
CA regular heart rate of 75 beats per minute
DThe patient having eaten recently
2.Med-surg: cardiovascular & respiratoryHard
A patient with heart failure wakes extremely breathless, coughing pink frothy sputum. BP is 168/96 mmHg and SpO₂ 86%. Help has been called. What is the best initial nursing action?
AEncourage the patient to walk to ease the breathing
BLie the patient flat with the legs raised on pillows
CSit the patient upright with the legs down and give oxygen
DGive a large IV fluid bolus to support the circulation
3.Med-surg: neuro, endocrine & renalMedium
A patient with gout has recurrent uric acid kidney stones. Which treatment helps prevent them?
AVitamin C supplements and a high-meat diet
BRestricting fluids in the evening only
CCalcium tablets and a low-fluid diet
DAllopurinol and making the urine less acidic
4.Med-surg: neuro, endocrine & renalHard
A patient with a long-term catheter has fever and rigors, and a catheter UTI is suspected. Which action is recommended before starting antibiotics?
AFlush the catheter with saline and continue
BReplace the catheter and take a sample from the new one
CRemove the catheter and leave it out permanently
DTake a sample from the drainage bag and send it to the lab
5.Med-surg: GI, perioperative & oncologyMedium
Which diet is usually recommended for a patient with cirrhosis and hepatic encephalopathy?
AOnly clear fluids for several weeks
BNormal protein and enough calories, with a late-evening snack
CNo food at all until the confusion settles
DA very low-protein diet for the rest of their life to lower ammonia
6.Med-surg: GI, perioperative & oncologyHard
After a high-voltage electrical injury, a patient's urine is dark red-brown. What does this suggest and what is the usual aim?
ANormal concentrated urine; restrict fluids
BMyoglobin from muscle damage; a higher urine output target
CA urinary infection; send a sample and wait for the result
DBleeding from the bladder; stop all fluids
7.Clinical nursingMedium
Which drug is used to reverse unfractionated heparin?
AProtamine sulfate
BNaloxone
CVitamin K (phytomenadione)
DFlumazenil
8.Clinical nursingHard
Which finding suggests hypocalcaemia?
ASpasm of the hand when a blood pressure cuff is inflated on the arm
BA flapping tremor of the outstretched hands
CA slow, irregular pulse with nausea and yellow-tinged vision
DSevere thirst with a large urine output and constipation
9.Lab values & electrolytesMedium
A patient has taken hydrochlorothiazide for several years. Which laboratory change is a recognized effect of this drug?
AA rise in serum potassium
BA rise in serum uric acid
CA fall in blood glucose
DA fall in serum calcium
10.Lab values & electrolytesHard
A patient with severe vomiting has a potassium of 3.0 mEq/L, a chloride of 88 mEq/L and a high bicarbonate. What pattern does this show?
ANormal results that need no follow-up
BLoss of stomach acid: low potassium and chloride, metabolic alkalosis
CHigh potassium with metabolic acidosis caused by dehydration
DDiabetic ketoacidosis with a high anion gap
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 131 mmol/L, glucose 24.2 mmol/L and urea 12.2 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 131 mmol/Lglucose 24.2 mmol/Lurea 12.2 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 21% oxygen shows PaO₂ 89 mmHg (11.9 kPa) and PaCO₂ 32 mmHg (4.3 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
A monitored patient is found unresponsive and not breathing normally, and no carotid pulse can be felt. The monitor shows this organised rhythm. What is this situation called? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1pulseless electrical activity (PEA)
2sinus tachycardia
3asystole
4ventricular fibrillation
15.Prioritization & delegationMedium
Which patient should the RN see first after receiving a report from the night nurse?
ADay 4 after bowel surgery, waiting for discharge teaching
BDay 1 after bowel surgery, new chest pain and heart rate 110/min
CDay 2 after bowel surgery, asking to start a soft diet
DDay 3 after bowel surgery, wants a shower and hair wash before breakfast
16.Prioritization & delegationHard
Which delegation is appropriate for a nursing assistant?
AGiving the first meal to a patient whose swallowing has not yet been screened after a stroke
BChecking a newly placed nasogastric tube before the first feed
CMonitoring a patient during the first 15 minutes of a blood transfusion
DCollecting a routine urine specimen from a stable patient
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · Cold hands with poor peripheral circulation
Why this is the answer
Poor perfusion (cold, shock, vasoconstriction), movement, dark nail varnish or bright ambient light can make readings unreliable. The nurse checks the waveform, warms the hand or uses an ear probe, and compares the reading with the clinical picture.
Answer
B · Cold hands with poor peripheral circulation
2.Med-surg: cardiovascular & respiratory
Answer: C · Sit the patient upright with the legs down and give oxygen
Why this is the answer
This is acute pulmonary oedema. Sitting upright with the legs dependent reduces venous return and eases breathing, and oxygen is titrated to target. IV diuretics, and sometimes nitrates or CPAP, are expected. Lying flat or giving fluids would worsen the congestion.
Answer
C · Sit the patient upright with the legs down and give oxygen
3.Med-surg: neuro, endocrine & renal
Answer: D · Allopurinol and making the urine less acidic
Why this is the answer
Uric acid stones form when urine is acidic and rich in uric acid. High fluid intake, alkalinising the urine (for example with potassium citrate) and allopurinol reduce the risk. Purine-rich foods are limited.
Answer
D · Allopurinol and making the urine less acidic
4.Med-surg: neuro, endocrine & renal
Answer: B · Replace the catheter and take a sample from the new one
Why this is the answer
Long-term catheters develop a biofilm that contaminates samples. Guidance usually advises replacing the catheter, collecting a sample from the new one and then starting antibiotics. Bag samples are not used.
Answer
B · Replace the catheter and take a sample from the new one
5.Med-surg: GI, perioperative & oncology
Answer: B · Normal protein and enough calories, with a late-evening snack
Why this is the answer
Protein restriction worsens malnutrition and muscle loss and is no longer routinely advised. Adequate protein and energy, small frequent meals and a late-evening snack are recommended.
Answer
B · Normal protein and enough calories, with a late-evening snack
6.Med-surg: GI, perioperative & oncology
Answer: B · Myoglobin from muscle damage; a higher urine output target
Why this is the answer
Electrical injury can cause extensive muscle breakdown, releasing myoglobin that can damage the kidneys. A higher urine output target is set, with fluids titrated and creatine kinase and kidney function monitored.
Answer
B · Myoglobin from muscle damage; a higher urine output target
7.Clinical nursing
Answer: A · Protamine sulfate
Why this is the answer
Protamine binds heparin and neutralises it. Vitamin K is used for warfarin.
Answer
A · Protamine sulfate
8.Clinical nursing
Answer: A · Spasm of the hand when a blood pressure cuff is inflated on the arm
Why this is the answer
Trousseau's sign, carpal spasm during cuff inflation, and Chvostek's sign, facial twitching on tapping the facial nerve, indicate neuromuscular irritability from low calcium.
Answer
A · Spasm of the hand when a blood pressure cuff is inflated on the arm
9.Lab values & electrolytes
Answer: B · A rise in serum uric acid
Why this is the answer
Thiazides reduce uric acid excretion and can trigger gout. They also tend to lower potassium, sodium and magnesium, raise calcium (by reducing its excretion) and raise blood glucose and lipids.Checked against:Hydrochlorothiazide · StatPearls (NCBI Bookshelf) (2026)
Answer
B · A rise in serum uric acid
10.Lab values & electrolytes
Answer: B · Loss of stomach acid: low potassium and chloride, metabolic alkalosis
Why this is the answer
Vomiting removes hydrochloric acid, so chloride falls and bicarbonate rises (metabolic alkalosis). The kidneys then lose potassium. Replacement usually includes 0.9% sodium chloride with potassium as prescribed.Checked against:Alkalosis · StatPearls (NCBI Bookshelf) (2024)
Answer
B · Loss of stomach acid: low potassium and chloride, metabolic alkalosis
11.Arterial blood gas interpretation
Answer: Osm = 298 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·131 + 24.2 + 12.2 = 298.4 ≈ 298 mOsm/kg
Answer
Osm = 298 mOsm/kg
12.Arterial blood gas interpretation
Answer: A–a gradient = 20.73 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9 × 0.04 = 0.36 s
RR = 19 × 0.04 = 0.76 s
Bazett’s formula
QTc = 0.36/√0.76 = 0.36/0.8718 = 0.413 s
Answer
QTc = 0.413 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (413 ms)
14.ECG rhythm strip interpretation
Answer: pulseless electrical activity (PEA)
Pulseless electrical activity (PEA): PEA cannot be seen on a strip. The monitor shows organised electrical activity (a rhythm other than VF, VT or asystole) but the patient has no palpable pulse, so it is recognised by checking the patient. In adult resuscitation guidelines PEA and asystole are the non-shockable cardiac arrest rhythms: high-quality CPR, epinephrine as soon as possible and a search for reversible causes (the Hs and Ts, such as hypovolaemia, hypoxia, tension pneumothorax and cardiac tamponade). VF and pulseless VT are the shockable rhythms.
What the strip shows
1. Rate: R–R = 12 small boxes, 1500 ÷ 12 ≈ 125 per minute.
2. Rhythm: regular, every R–R is 0.48 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.14 s, constant, within 0.12–0.20 s.
5. QRS: 0.10 s, narrow (below 0.12 s).
sinus tachycardia
What the patient shows
no pulse despite organised electrical activity: pulseless electrical activity (PEA), a non-shockable cardiac arrest rhythm
Answer
pulseless electrical activity (PEA)
Answer
pulseless electrical activity (PEA)
PEA is recognised at the bedside, never from the strip alone. This is exam practice, not clinical guidance.
15.Prioritization & delegation
Answer: B · Day 1 after bowel surgery, new chest pain and heart rate 110/min
Why this is the answer
New chest pain and tachycardia after surgery could be a myocardial infarction or pulmonary embolism. This patient needs immediate assessment; the others have routine needs.
Answer
B · Day 1 after bowel surgery, new chest pain and heart rate 110/min
16.Prioritization & delegation
Answer: D · Collecting a routine urine specimen from a stable patient
Why this is the answer
Collecting a routine urine sample from a stable patient is predictable and delegable. Confirming tube placement, feeding before a swallow screen and monitoring the start of a transfusion all need nursing assessment.
Answer
D · Collecting a routine urine specimen from a stable patient