Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
In heart failure, why does activation of the renin–angiotensin–aldosterone system worsen symptoms over time?
AIt makes the kidneys pass too much dilute urine each day
BIt slows the heart rate dangerously
CIt causes sodium and water retention and vasoconstriction
DIt lowers the blood pressure to very low levels over time
2.Med-surg: cardiovascular & respiratoryHard
A patient recovering from an MI is anxious about returning to normal life. Which intervention best supports recovery?
AAdvice to rest in bed for three months
BReferral to cardiac rehabilitation
CAdvice to stop tablets once they feel well
DAdvice to avoid all exercise permanently
3.Med-surg: neuro, endocrine & renalMedium
Which headache feature most suggests raised intracranial pressure from a brain tumour?
AOnly present after reading for a long time
BA tight band across the forehead that eases with rest
CBetter in the morning and worse with stress
DWorse on waking and on coughing, with vomiting
4.Med-surg: neuro, endocrine & renalHard
A drowsy patient's glucose meter shows "HI". What should the nurse do?
ATreat it as very high, check ketones and escalate
BGive glucose gel in case the reading is wrong
CRecord "normal" in the notes because no number appears
DAssume the meter is broken and recheck tomorrow
5.Med-surg: GI, perioperative & oncologyMedium
Which factor can precipitate hepatic encephalopathy in a patient with cirrhosis?
AConstipation
BA low-salt diet
CA high fluid intake
DRegular gentle walking
6.Med-surg: GI, perioperative & oncologyHard
Why is folinic acid (leucovorin) given after high-dose methotrexate?
ATo rescue normal cells from methotrexate toxicity
BTo treat the patient's anaemia only
CTo increase the anticancer effect on the tumour
DTo prevent hair loss during treatment
7.Clinical nursingMedium
Which equipment must always be kept at the bedside of a patient with a tracheostomy?
ASpare tracheostomy tubes, including one a size smaller, and working suction
BA blood pressure cuff and a spare nasal cannula and oxygen mask only
CA peak flow meter and a nebuliser
DA blood glucose meter and a spare urinary catheter of the same size
8.Clinical nursingHard
Why is hypokalaemia particularly dangerous in a patient taking digoxin?
ADigoxin raises potassium to dangerous levels when it is already low
BLow potassium stops digoxin from being absorbed
CLow potassium increases the risk of digoxin toxicity
DLow potassium makes digoxin work too slowly
9.Lab values & electrolytesMedium
A patient taking furosemide has a potassium of 3.3 mEq/L and is told to eat more potassium-rich foods. Which snack is the best choice?
APlain crackers
BWhite bread
CRice cakes
DDried apricots
10.Lab values & electrolytesHard
A patient with severe hypertriglyceridemia has a measured sodium of 128 mEq/L, but a measured serum osmolality is normal, and the patient has no symptoms. What is the most likely explanation?
APseudohyponatremia, an artifact caused by very high lipids
BHyponatremia caused by severe hyperglycemia in diabetes
CHyponatremia caused by drinking far too much water
DTrue hyponatremia from SIADH that needs fluid restriction
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 20 mmHg (2.7 kPa). Use the rule that in chronic respiratory alkalosis HCO₃⁻ falls by 5 mmol/L for every 10 mmHg that PaCO₂ is below 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
A practice gas shows a metabolic alkalosis with HCO₃⁻ 39 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 39 mmol/L
PaCO₂ = mmHg
13.ECG rhythm strip interpretationMedium
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus tachycardia
2supraventricular tachycardia (SVT)
3normal sinus rhythm
4atrial fibrillation
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1second-degree AV block type II
2second-degree AV block type I (Wenckebach)
3sinus bradycardia
4first-degree AV block
15.Prioritization & delegationMedium
A patient on hemodialysis has an arteriovenous fistula in the left arm. Which instruction should the nurse give the nursing assistant?
AKeep the left arm wrapped tightly in a bandage at night
BMeasure blood pressure on the left arm only, every 4 hours
CDo not measure blood pressure on the left arm
DHelp the patient carry shopping bags on the left arm
16.Prioritization & delegationHard
A patient with COPD on 2 L/min oxygen becomes drowsy and hard to wake. The SpO₂ is 93%. What is the priority?
ALet the patient sleep, because the saturation is above target
BGive the as-needed sedative so the patient rests comfortably
CIncrease the oxygen to 6 L/min so that the saturation goes even higher than now
DAssess breathing and escalate for a blood gas, as carbon dioxide may be rising
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · It causes sodium and water retention and vasoconstriction
Why this is the answer
Reduced cardiac output activates RAAS and the sympathetic system. Angiotensin II constricts vessels (raising afterload) and aldosterone retains sodium and water (raising preload and congestion). ACE inhibitors, ARBs, mineralocorticoid antagonists and beta-blockers block these harmful loops.
Answer
C · It causes sodium and water retention and vasoconstriction
2.Med-surg: cardiovascular & respiratory
Answer: B · Referral to cardiac rehabilitation
Why this is the answer
Cardiac rehabilitation combines supervised exercise, risk factor education, medication advice and psychological support. It improves quality of life and reduces cardiovascular mortality and readmissions. Patients are encouraged to return gradually to activity, including work, driving and sex, according to advice.
Answer
B · Referral to cardiac rehabilitation
3.Med-surg: neuro, endocrine & renal
Answer: D · Worse on waking and on coughing, with vomiting
Why this is the answer
Headaches from raised ICP are often worse on waking, when coughing, sneezing or bending, and may come with vomiting or visual changes. A new headache with these features needs prompt assessment.
Answer
D · Worse on waking and on coughing, with vomiting
4.Med-surg: neuro, endocrine & renal
Answer: A · Treat it as very high, check ketones and escalate
Why this is the answer
"HI" means the glucose is above the meter's upper range. In a drowsy patient this may be DKA or HHS. A laboratory glucose, ketones, observations and urgent medical review are needed.
Answer
A · Treat it as very high, check ketones and escalate
5.Med-surg: GI, perioperative & oncology
Answer: A · Constipation
Why this is the answer
Constipation, GI bleeding, infection, dehydration, low potassium and sedative drugs can trigger encephalopathy. Keeping the bowels open, for example with lactulose, reduces ammonia absorption.
Answer
A · Constipation
6.Med-surg: GI, perioperative & oncology
Answer: A · To rescue normal cells from methotrexate toxicity
Why this is the answer
Methotrexate inhibits dihydrofolate reductase. Timed folinic acid bypasses this block in normal cells, reducing toxicity such as mucositis and myelosuppression, while methotrexate levels and kidney function are monitored.
Answer
A · To rescue normal cells from methotrexate toxicity
7.Clinical nursing
Answer: A · Spare tracheostomy tubes, including one a size smaller, and working suction
Why this is the answer
Emergency equipment such as spare tubes (same size and one smaller), suction, oxygen and tracheal dilators must be at the bedside. This allows rapid management of a blocked or displaced tube.
Answer
A · Spare tracheostomy tubes, including one a size smaller, and working suction
8.Clinical nursing
Answer: C · Low potassium increases the risk of digoxin toxicity
Why this is the answer
Digoxin binds to the sodium–potassium ATPase at the site potassium normally uses. When potassium is low, digoxin binds more, raising the risk of toxicity and arrhythmias.
Answer
C · Low potassium increases the risk of digoxin toxicity
9.Lab values & electrolytes
Answer: D · Dried apricots
Why this is the answer
Dried fruits such as apricots, raisins and prunes are rich in potassium, as are bananas, oranges, potatoes, beans and tomatoes. Refined grain products such as white bread and crackers are low in potassium.Checked against:Potassium in diet · MedlinePlus (NIH) (2026)
Answer
D · Dried apricots
10.Lab values & electrolytes
Answer: A · Pseudohyponatremia, an artifact caused by very high lipids
Why this is the answer
Very high lipids or proteins take up part of the plasma volume, so some laboratory methods report a falsely low sodium. The osmolality and the sodium measured by direct methods are normal. Treating this "hyponatremia" would be harmful.
Answer
A · Pseudohyponatremia, an artifact caused by very high lipids
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 14 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|20 − 40| = 20 mmHg → 2 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 − 5·2 = 14 mmol/L
Answer
HCO₃⁻ = 14 mmol/L
12.Arterial blood gas interpretation
Answer: PaCO₂ = 48.3 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·39 + 21 = 48.3 mmHg
Answer
PaCO₂ = 48.3 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
13.ECG rhythm strip interpretation
Answer: sinus tachycardia
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 14 small boxes, 1500 ÷ 14 ≈ 107 per minute.
2. Rhythm: regular, every R–R is 0.56 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.14 s, constant, within 0.12–0.20 s.
5. QRS: 0.08 s, narrow (below 0.12 s).
Interpretation
sinus tachycardia
Answer
sinus tachycardia
14.ECG rhythm strip interpretation
Answer: second-degree AV block type II
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: 4 QRS complexes in 6 s, × 10 = 40 per minute.
2. Rhythm: the P waves are regular; R–R is regular except for a long pause where a QRS is missing.
3. P waves: upright and regular (P–P 0.96 s, 63 per minute); one P in every 3 is not followed by a QRS.
4. PR interval: constant at 0.18 s in the conducted beats.
5. QRS: 0.08 s, narrow (below 0.12 s).
Interpretation
second-degree AV block type II
Answer
second-degree AV block type II
Type II and third-degree blocks are the ones that can suddenly progress, so textbooks rank them as more serious than type I.
15.Prioritization & delegation
Answer: C · Do not measure blood pressure on the left arm
Why this is the answer
Blood pressure cuffs, tight bands and heavy loads can damage or block a fistula. The arm with the access is protected, and the nurse checks it for a thrill and bruit.
Answer
C · Do not measure blood pressure on the left arm
16.Prioritization & delegation
Answer: D · Assess breathing and escalate for a blood gas, as carbon dioxide may be rising
Why this is the answer
In COPD, drowsiness can be a sign of carbon dioxide retention (hypercapnia), even when the saturation is acceptable. The nurse assesses breathing, escalates and avoids extra oxygen or sedatives that could worsen it.
Answer
D · Assess breathing and escalate for a blood gas, as carbon dioxide may be rising