Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Virchow's triad describes three factors that promote venous thrombosis. Which patient factor represents venous stasis?
ATaking an oestrogen-containing pill
BAn inherited clotting disorder
CImmobility after major surgery
DDamage to a vein during hip surgery
2.Med-surg: cardiovascular & respiratoryHard
A patient who has had a total laryngectomy becomes breathless and needs oxygen. How should it be given?
AVia a mask or humidified device over the neck stoma
BVia nasal cannula at 2 L/min
CVia a non-rebreather mask over the mouth only
DVia a standard face mask over the nose and mouth
3.Med-surg: neuro, endocrine & renalMedium
A patient takes levodopa for Parkinson's disease. Which teaching point is correct?
AThe drug cures the disease if taken for a full year
BThe tablets work best taken with a large steak dinner
CLarge high-protein meals can reduce how well the drug works
DStop the drug for a day each week to avoid tolerance
4.Med-surg: neuro, endocrine & renalHard
A patient has erratic glucose readings. The nurse finds a soft, rubbery lump where they always inject. What is the most important teaching?
AMassage the lump firmly after every injection
BUse healthy sites and check glucose often, as less insulin may be needed
CKeep injecting into the lump, because it hurts less there
DDouble the insulin dose because the lump blocks the insulin
5.Med-surg: GI, perioperative & oncologyMedium
Why is a pregnancy test often done before surgery in women who could be pregnant?
APregnant women cannot sign consent forms
BIt is needed to calculate the anaesthetic drug dose
CAnaesthesia, drugs and some tests may harm a fetus
DPregnancy always makes surgery impossible
6.Med-surg: GI, perioperative & oncologyHard
A patient with a permanent pacemaker is booked for surgery using monopolar diathermy. Why must the team know?
ADiathermy can interfere with the pacemaker's function
BThe patient cannot have any anaesthetic at all
CThe pacemaker will always be removed during surgery
DPacemakers stop all bleeding during surgery
7.Clinical nursingMedium
A new colostomy stoma appears dark purple to black on the second postoperative day. What does this indicate?
AA normal healthy stoma
BPossible ischaemia of the stoma, which needs urgent review
CNormal postoperative bruising of the stoma that needs no action
DConstipation
8.Clinical nursingHard
A dying patient has noisy, rattling breathing caused by secretions in the throat and is unconscious. Which approach is appropriate?
ABegin rapid intravenous fluids to thin and clear the secretions
BStart deep oropharyngeal suctioning every 10 minutes through the night
CReposition, consider prescribed antisecretory drugs and support the family
DTell the family that the patient is suffocating and needs ventilation
9.Lab values & electrolytesMedium
A patient is on an IV insulin infusion protocol in the ICU. How often is the blood glucose usually checked?
AOnly if symptoms occur
BAbout every hour
COnce a day before breakfast
DOnce every 12 hours
10.Lab values & electrolytesHard
A patient took a large overdose of acetaminophen (paracetamol) 24 hours ago. Which laboratory changes are most expected?
AA low ALT and AST and a low INR
BA high troponin with a normal ALT
CA very high ALT and AST and a rising INR
DA low white count with normal liver tests
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 6 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 6 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.33, PaCO₂ 35 mmHg (4.7 kPa), HCO₃⁻ 18 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.33PaCO₂ 35 mmHg (4.7 kPa)HCO₃⁻ 18 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1first-degree AV block
2sinus bradycardia
3junctional rhythm
4sinus tachycardia
14.ECG rhythm strip interpretationHard
This lead II strip shows second-degree AV block type I (Wenckebach). Measure the PR interval of the last conducted beat before a non-conducted P wave (the longest PR), in seconds.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
longest PR = s
15.Prioritization & delegationMedium
Five days after starting heparin, a patient’s platelet count has fallen by more than half. What should the nurse suspect?
AHeparin-induced thrombocytopenia
BAn expected effect that needs no action
CVitamin K deficiency
DIron deficiency anemia
16.Prioritization & delegationHard
A patient rescued from a house fire has burns to the face, singed nasal hair and a hoarse voice. What is the priority?
AProtecting the airway, preparing for early airway support
BGiving pain relief
CCleaning and dressing the facial burns
DStarting IV fluid resuscitation calculated from the burn size
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Immobility after major surgery
Why this is the answer
Virchow's triad is stasis of blood, vessel wall injury and hypercoagulability. Immobility, long journeys and heart failure cause stasis. Surgery and trauma injure vessel walls. Oestrogen, cancer, pregnancy and inherited thrombophilias increase coagulability.
Answer
C · Immobility after major surgery
2.Med-surg: cardiovascular & respiratory
Answer: A · Via a mask or humidified device over the neck stoma
Why this is the answer
A total laryngectomy separates the trachea from the upper airway, so the patient breathes only through the neck stoma. Oxygen and any rescue breaths must be given via the stoma. These patients are "neck breathers" and often carry an alert card.
Answer
A · Via a mask or humidified device over the neck stoma
3.Med-surg: neuro, endocrine & renal
Answer: C · Large high-protein meals can reduce how well the drug works
Why this is the answer
Protein-rich meals can compete with levodopa for absorption and entry into the brain, which reduces its effect. Patients are often advised to take doses at consistent times relative to meals. Levodopa controls symptoms but does not stop the disease.
Answer
C · Large high-protein meals can reduce how well the drug works
4.Med-surg: neuro, endocrine & renal
Answer: B · Use healthy sites and check glucose often, as less insulin may be needed
Why this is the answer
Lipohypertrophy causes poor and unpredictable absorption. When the patient switches to healthy tissue, more insulin is absorbed, so hypos can occur. Glucose is monitored closely, and doses may need to be reduced.
Answer
B · Use healthy sites and check glucose often, as less insulin may be needed
5.Med-surg: GI, perioperative & oncology
Answer: C · Anaesthesia, drugs and some tests may harm a fetus
Why this is the answer
Unknown pregnancy can change the decision to operate, the timing, and the choice of drugs and X-rays. Testing is offered with consent, according to local policy.
Answer
C · Anaesthesia, drugs and some tests may harm a fetus
6.Med-surg: GI, perioperative & oncology
Answer: A · Diathermy can interfere with the pacemaker's function
Why this is the answer
Electrical interference from monopolar diathermy can inhibit or reprogram pacemakers and defibrillators. The team plans ahead, for example using bipolar diathermy, placing the plate carefully or having the device checked.
Answer
A · Diathermy can interfere with the pacemaker's function
7.Clinical nursing
Answer: B · Possible ischaemia of the stoma, which needs urgent review
Why this is the answer
A dusky or black stoma suggests poor blood supply and possible necrosis, and must be reported promptly to the surgical team.
Answer
B · Possible ischaemia of the stoma, which needs urgent review
8.Clinical nursing
Answer: C · Reposition, consider prescribed antisecretory drugs and support the family
Why this is the answer
The "death rattle" is managed by repositioning, mouth care and sometimes drugs that reduce secretions. Explaining it to relatives eases their distress.
Answer
C · Reposition, consider prescribed antisecretory drugs and support the family
9.Lab values & electrolytes
Answer: B · About every hour
Why this is the answer
IV insulin acts quickly and has a short half-life, so glucose is usually checked hourly (or as the protocol specifies) and the rate adjusted. This reduces the risk of hypoglycemia and keeps glucose in the target range.
Answer
B · About every hour
10.Lab values & electrolytes
Answer: C · A very high ALT and AST and a rising INR
Why this is the answer
A toxic dose damages liver cells, so ALT and AST rise steeply, and liver failure raises the INR. Acetylcysteine is the antidote and works best when given early.
Answer
C · A very high ALT and AST and a rising INR
11.Arterial blood gas interpretation
Answer: PaCO₂ = 17 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·6 + 8 = 17 mmHg
range: 15–19 mmHg
Answer
PaCO₂ = 17 mmHg
12.Arterial blood gas interpretation
Answer: appropriate compensation
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·18 + 8 = 35 → 33–37 mmHg
Compare
measured: 35 mmHg → appropriate compensation
Answer
appropriate compensation
13.ECG rhythm strip interpretation
Answer: first-degree AV block
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 24 small boxes, 1500 ÷ 24 ≈ 63 per minute.
2. Rhythm: regular, every R–R is 0.96 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.34 s, constant, longer than 0.20 s.
5. QRS: 0.08 s, narrow (below 0.12 s).
Interpretation
first-degree AV block
Answer
first-degree AV block
14.ECG rhythm strip interpretation
Answer:longest PR = 0.38 s
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
March out the P waves
P–P = 1.00 s, regular; one P wave in every 4 is not conducted
PR in each group
PR₁ = 0.16 s, PR₂ = 0.30 s, PR₃ = 0.38 s
Answer
longest PR = 0.38 s
The biggest step in PR comes between the first and second beats of a group; later steps are smaller, which is why the R–R intervals shorten before the pause.
15.Prioritization & delegation
Answer: A · Heparin-induced thrombocytopenia
Why this is the answer
Heparin-induced thrombocytopenia usually appears 5–10 days after starting heparin, with a large fall in platelets and a risk of clotting. The nurse reports at once so heparin can be stopped.
Answer
A · Heparin-induced thrombocytopenia
16.Prioritization & delegation
Answer: A · Protecting the airway, preparing for early airway support
Why this is the answer
Singed nasal hair and hoarseness suggest inhalation injury. The upper airway can swell and close within hours, so it is protected early. Fluids, pain relief and wound care follow.
Answer
A · Protecting the airway, preparing for early airway support