Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which advice is most helpful for a patient with Raynaud's phenomenon?
ASoak the hands in cold water to toughen the vessels
BTake a decongestant tablet before going outdoors
CKeep the whole body warm, wear gloves and stop smoking
DRub the fingers hard with snow during an attack
2.Med-surg: cardiovascular & respiratoryHard
After positive end-expiratory pressure (PEEP) is increased on a ventilated patient, the blood pressure falls. What is the most likely reason?
APEEP causes immediate blood loss from the alveolar capillaries
BPEEP lowers the blood oxygen level
CPEEP directly weakens the heart muscle and its contraction
DHigher chest pressure reduces venous return to the heart
3.Med-surg: neuro, endocrine & renalMedium
A patient has just started haemodialysis. What usually happens to their protein needs?
AProtein must be replaced only by IV infusion
BThey stay exactly the same as they were before dialysis
CThey increase, because dialysis removes amino acids
DThey fall to almost zero to rest the kidneys
4.Med-surg: neuro, endocrine & renalHard
Which of these patients with acute ischaemic stroke is least likely to be eligible for IV thrombolysis?
AA patient who had major abdominal surgery five days ago
BA patient whose blood pressure is 170/95 mmHg
CA patient whose symptoms began 90 minutes ago
DA patient whose CT scan shows no sign of any intracranial bleeding
5.Med-surg: GI, perioperative & oncologyMedium
What is a paralytic ileus?
AAn infection of the bowel wall with fever
BA blockage of the bowel lumen by a tumour
CLoss of bowel movement without a physical blockage
DA twist in the large bowel cutting off its blood supply
6.Med-surg: GI, perioperative & oncologyHard
Two days after surgery, a patient on regular ibuprofen has a low urine output and a rising creatinine, and intake has been poor. What should the nurse do?
AChange to a higher-strength NSAID tablet
BGive the next dose with extra food
CIncrease the dose to treat the pain better and encourage fluids
DWithhold the next dose and report to the prescriber
7.Clinical nursingMedium
Why is an urgent brain scan needed before thrombolysis for a suspected stroke?
ATo measure the size of the ventricles
BTo check for brain tumours only
CTo confirm the patient's age
DTo rule out bleeding in the brain
8.Clinical nursingHard
Why should "units" never be abbreviated to "U" or "IU" on an insulin prescription?
AThe abbreviation is only allowed on prescriptions for children
BIt changes the type of insulin given
CPharmacists cannot dispense insulin written that way
DThe letters can be misread as a zero, causing a tenfold overdose
9.Lab values & electrolytesMedium
A patient receives repeated nebulized albuterol (salbutamol) for severe asthma. Which laboratory change should the nurse watch for?
AA rise in serum calcium
BA fall in serum potassium
CA rise in serum sodium
DA fall in blood glucose
10.Lab values & electrolytesHard
After a crush injury, a patient's urine dipstick is strongly positive for blood, but microscopy shows almost no red cells. CK is very high. What best explains this?
AA kidney stone is scraping the ureter lining
BThe sample was contaminated with menstrual blood
CBleeding is coming from the bladder lining
DMyoglobin from damaged muscle is in the urine
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 32 mmHg (4.3 kPa). Use the rule that in chronic respiratory alkalosis HCO₃⁻ falls by 5 mmol/L for every 10 mmHg that PaCO₂ is below 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1atrial fibrillation
2first-degree AV block
3second-degree AV block type I (Wenckebach)
4third-degree (complete) AV block
15.Prioritization & delegationMedium
A patient receiving IV magnesium sulfate for pre-eclampsia has absent knee reflexes and a respiratory rate of 10/min. What does the nurse do first?
AIncrease the infusion to prevent a seizure
BGive oral fluids to help clear the drug faster
CTurn the patient onto her back and recheck later
DStop the magnesium infusion and call for help
16.Prioritization & delegationHard
A trauma patient has an open leg fracture, absent breath sounds on one side, a trachea shifted to the other side and a falling blood pressure. Which problem is the priority?
AThe open fracture of the leg
BThe pain from the fracture
CThe suspected tension pneumothorax
DThe risk of wound infection
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Keep the whole body warm, wear gloves and stop smoking
Why this is the answer
Keeping the core and hands warm, wearing gloves and stopping smoking reduce attacks. Vasoconstrictors such as decongestants and nicotine make it worse. During an attack, gentle warming of the hands is advised.
Answer
C · Keep the whole body warm, wear gloves and stop smoking
2.Med-surg: cardiovascular & respiratory
Answer: D · Higher chest pressure reduces venous return to the heart
Why this is the answer
PEEP keeps alveoli open and improves oxygenation, but higher intrathoracic pressure impedes venous return, reducing preload and cardiac output, especially in hypovolaemic patients. The team may give fluid or adjust PEEP. High pressures also risk barotrauma.
Answer
D · Higher chest pressure reduces venous return to the heart
3.Med-surg: neuro, endocrine & renal
Answer: C · They increase, because dialysis removes amino acids
Why this is the answer
Before dialysis, a moderate protein intake may be advised. Dialysis removes amino acids and protein, so needs rise, and malnutrition is a common risk. A renal dietitian sets individual targets.
Answer
C · They increase, because dialysis removes amino acids
4.Med-surg: neuro, endocrine & renal
Answer: A · A patient who had major abdominal surgery five days ago
Why this is the answer
Recent major surgery (within roughly 14 days in many guidelines) greatly increases the bleeding risk and is a contraindication to thrombolysis. Onset within 4.5 hours, a blood pressure below 185/110 mmHg and a CT without haemorrhage are conditions that permit it.
Answer
A · A patient who had major abdominal surgery five days ago
5.Med-surg: GI, perioperative & oncology
Answer: C · Loss of bowel movement without a physical blockage
Why this is the answer
Paralytic ileus is a functional obstruction where peristalsis stops, often after abdominal surgery, with opioid use, infection or electrolyte disturbance (especially low potassium). Bowel sounds are reduced or absent.
Answer
C · Loss of bowel movement without a physical blockage
6.Med-surg: GI, perioperative & oncology
Answer: D · Withhold the next dose and report to the prescriber
Why this is the answer
NSAIDs can cause acute kidney injury, particularly with hypovolaemia, older age or other nephrotoxic drugs. The nurse withholds and reports, and fluid status and other analgesia are reviewed.
Answer
D · Withhold the next dose and report to the prescriber
7.Clinical nursing
Answer: D · To rule out bleeding in the brain
Why this is the answer
A CT scan distinguishes haemorrhagic from ischaemic stroke. Clot-busting drugs are only given when bleeding has been excluded and other criteria are met.
Answer
D · To rule out bleeding in the brain
8.Clinical nursing
Answer: D · The letters can be misread as a zero, causing a tenfold overdose
Why this is the answer
"U" can be misread as 0, so "10U" might be read as 100, and "IU" can be mistaken for "IV" or "10". Writing "units" in full is a standard safety rule (ISMP), because insulin errors can cause severe hypoglycaemia.
Answer
D · The letters can be misread as a zero, causing a tenfold overdose
9.Lab values & electrolytes
Answer: B · A fall in serum potassium
Why this is the answer
Beta-2 agonists push potassium into cells and can cause hypokalemia, especially at high doses; they also raise blood glucose. For this reason nebulized albuterol is sometimes used as an extra treatment for hyperkalemia.
Answer
B · A fall in serum potassium
10.Lab values & electrolytes
Answer: D · Myoglobin from damaged muscle is in the urine
Why this is the answer
The dipstick blood test detects heme, which is present in both hemoglobin and myoglobin. Positive "blood" without red cells, together with a very high CK, indicates myoglobinuria from rhabdomyolysis, which can damage the kidneys. IV fluids and close monitoring of urine output and potassium are needed.Checked against:Myoglobin urine test · MedlinePlus (NIH) (2025); Rhabdomyolysis · MedlinePlus (NIH) (2025); Creatine Kinase · MedlinePlus (NIH) (2023)
Answer
D · Myoglobin from damaged muscle is in the urine
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 20 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|32 − 40| = 8 mmHg → 0.8 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 − 5·0.8 = 20 mmol/L
Answer
HCO₃⁻ = 20 mmol/L
12.Arterial blood gas interpretation
Answer: AGc = 20.5 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 144 − (111 + 13) = 20
Correction for albumin
20 + 0.25·(40 − 38) = 20.5 mmol/L
Answer
AGc = 20.5 mmol/L
Above about 12 after correction: a high anion gap.
13.ECG rhythm strip interpretation
Answer: QTc = 0.415 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 10.5 × 0.04 = 0.42 s
RR = 26 × 0.04 = 1.04 s
Fridericia’s formula
QTc = 0.42/∛1.04 = 0.42/1.013 = 0.415 s
Answer
QTc = 0.415 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (415 ms)
14.ECG rhythm strip interpretation
Answer: second-degree AV block type I (Wenckebach)
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: 4 QRS complexes in 6 s, × 10 = 40 per minute.
2. Rhythm: regularly irregular, the QRS complexes come in groups separated by a pause (group beating).
3. P waves: upright and regular (P–P 1.00 s, 60 per minute); one P in every 3 is not followed by a QRS.
4. PR interval: lengthens 0.18 → 0.30 s, then a P wave is not conducted.
5. QRS: 0.08 s, narrow (below 0.12 s).
Interpretation
second-degree AV block type I (Wenckebach)
Answer
second-degree AV block type I (Wenckebach)
15.Prioritization & delegation
Answer: D · Stop the magnesium infusion and call for help
Why this is the answer
Loss of deep tendon reflexes and slow breathing suggest magnesium toxicity. The nurse stops the infusion, supports breathing and escalates; calcium gluconate is the antidote kept ready.
Answer
D · Stop the magnesium infusion and call for help
16.Prioritization & delegation
Answer: C · The suspected tension pneumothorax
Why this is the answer
A shifted trachea, absent breath sounds and hypotension suggest tension pneumothorax, which threatens breathing and circulation within minutes. The fracture is important, but it comes after the immediate life threat.