Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Why is active tuberculosis treated with several drugs for at least six months?
ABecause the bacteria are resistant to all drugs at first
BTo reduce the number of side effects compared with one drug
CTo kill slow-growing bacteria and prevent drug resistance
DBecause each drug works on a different organ only
2.Med-surg: cardiovascular & respiratoryHard
Before the morning dose of digoxin, a patient's apical pulse is 54/min and they feel nauseated. What should the nurse do?
AGive the dose and an antiemetic, then recheck the pulse tomorrow
BGive half the dose and recheck the pulse in an hour
CWithhold the dose and report it, as toxicity is possible
DGive the dose, because only a radial pulse counts
3.Med-surg: neuro, endocrine & renalMedium
Which set of results best supports DKA rather than HHS?
AHigh ketones, pH below 7.3 and low bicarbonate
BGlucose above 30 mmol/L with a normal pH
CVery high osmolality with only trace ketones in the blood
DNormal ketones and a normal bicarbonate
4.Med-surg: neuro, endocrine & renalHard
A patient in thyroid storm has a temperature of 40 °C (104 °F). Which measure for the fever is usually avoided?
AParacetamol (acetaminophen)
BCooling blankets
CAspirin
DFanning with cool air
5.Med-surg: GI, perioperative & oncologyMedium
A patient has taken oral prednisolone daily for many months. Why is this important before surgery?
ASteroids must always be stopped a full week before any type of surgery
BThey may need extra steroid cover to prevent an adrenal crisis
CSteroids prevent all wound infections after surgery
DSteroids make the anaesthetic drugs last much longer
6.Med-surg: GI, perioperative & oncologyHard
Which history should most alert the nurse to a possible latex allergy before surgery?
AFeeling sick after eating shellfish once
BA rash after taking amoxicillin as a child, with a family history of asthma
CItching with bananas, avocado and kiwi, and many operations
DHay fever every spring since childhood
7.Clinical nursingMedium
Why are patients asked to fast before a general anaesthetic?
ATo reduce the risk of aspirating stomach contents
BTo prevent postoperative constipation and abdominal bloating
CTo lower the blood glucose before surgery
DTo make the surgery shorter
8.Clinical nursingHard
A nurse is unsure whether a prescribed dose of a high-risk drug is correct. What is the safest action?
AGive the dose because the doctor has signed the prescription
BAsk the patient whether the dose looks the same as usual and give it
CGive half the dose as a compromise until the doctor is available
DWithhold it and check with the prescriber or pharmacist first
9.Lab values & electrolytesMedium
An older adult with chronic kidney disease takes glyburide (glibenclamide, a sulfonylurea) and has repeated low glucose readings. Why is this a concern?
AThe drug stops working entirely when the kidneys fail
BThe drug makes the glucose meter read falsely low
CThe drug causes high potassium that lowers the glucose
DThe drug and its metabolites build up and cause long lows
10.Lab values & electrolytesHard
A patient has a hemoglobin of 11.2 g/dL (112 g/L), an MCV of 64 fL, a normal ferritin and a normal-to-high red cell count. What is the most likely cause?
AThalassemia trait
BIron deficiency
CAcute blood loss
DVitamin B12 deficiency
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 12 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 12 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.13, PaCO₂ 28 mmHg (3.7 kPa), HCO₃⁻ 9 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.13PaCO₂ 28 mmHg (3.7 kPa)HCO₃⁻ 9 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1third-degree (complete) AV block
2second-degree AV block type I (Wenckebach)
3first-degree AV block
4second-degree AV block type II
15.Prioritization & delegationMedium
A patient just told they have cancer is crying, but has also vomited several times and cannot keep fluids down. What does the nurse address first?
AContacting the hospital chaplain
BTeaching about chemotherapy
CEmotional support about the diagnosis
DThe vomiting and fluid loss
16.Prioritization & delegationHard
An adult has burns over 40% of the body with no signs of airway injury. Which treatment is the priority during the first hours?
ALarge-volume IV fluids with close monitoring of urine output
BGiving a high-protein meal to support healing
CApplying antibiotic cream to all the burns before anything else
DStarting physiotherapy to prevent contractures straight away
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · To kill slow-growing bacteria and prevent drug resistance
Why this is the answer
Mycobacterium tuberculosis grows slowly and has resistant mutants in any large population. A combination (for example rifampicin, isoniazid, pyrazinamide and ethambutol at first) kills susceptible and resistant bacteria and prevents resistance. Stopping early risks relapse and multidrug-resistant TB.
Answer
C · To kill slow-growing bacteria and prevent drug resistance
2.Med-surg: cardiovascular & respiratory
Answer: C · Withhold the dose and report it, as toxicity is possible
Why this is the answer
A common rule is to withhold digoxin and inform the prescriber if the apical pulse is below 60/min (or below the set parameter) or if there are toxic features such as nausea, vomiting, visual disturbance or a new arrhythmia. A digoxin level, ECG, potassium and renal function are usually checked. The nurse does not change a dose on their own initiative.
Answer
C · Withhold the dose and report it, as toxicity is possible
3.Med-surg: neuro, endocrine & renal
Answer: A · High ketones, pH below 7.3 and low bicarbonate
Why this is the answer
DKA is defined by hyperglycaemia (or known diabetes), ketonaemia (for example >3 mmol/L) and metabolic acidosis (pH < 7.3 or bicarbonate < 15 mmol/L in UK criteria). HHS has very high glucose and high osmolality (often > 320 mOsm/kg) with little ketosis and no significant acidosis.
Answer
A · High ketones, pH below 7.3 and low bicarbonate
4.Med-surg: neuro, endocrine & renal
Answer: C · Aspirin
Why this is the answer
Aspirin (salicylates) displaces thyroid hormone from binding proteins, raising free hormone levels. Paracetamol (acetaminophen) and external cooling are used instead, together with treatment for the storm itself.
Answer
C · Aspirin
5.Med-surg: GI, perioperative & oncology
Answer: B · They may need extra steroid cover to prevent an adrenal crisis
Why this is the answer
Long-term steroids suppress the adrenal glands, so they cannot raise cortisol in response to surgical stress. Extra steroid cover may be prescribed, and steroids are not stopped suddenly. Healing may also be slower.
Answer
B · They may need extra steroid cover to prevent an adrenal crisis
6.Med-surg: GI, perioperative & oncology
Answer: C · Itching with bananas, avocado and kiwi, and many operations
Why this is the answer
Latex–fruit syndrome links latex allergy with foods such as banana, avocado, kiwi and chestnut. Repeated exposure, for example through many operations or catheters, also increases risk.
Answer
C · Itching with bananas, avocado and kiwi, and many operations
7.Clinical nursing
Answer: A · To reduce the risk of aspirating stomach contents
Why this is the answer
Under general anaesthesia the airway reflexes are lost, so food or fluid in the stomach could be regurgitated and inhaled. Fasting reduces the risk of aspiration pneumonitis.
Answer
A · To reduce the risk of aspirating stomach contents
8.Clinical nursing
Answer: D · Withhold it and check with the prescriber or pharmacist first
Why this is the answer
Nurses must understand any drug they administer. If a dose seems wrong, they should check with the prescriber or pharmacist and document the action.
Answer
D · Withhold it and check with the prescriber or pharmacist first
9.Lab values & electrolytes
Answer: D · The drug and its metabolites build up and cause long lows
Why this is the answer
Glyburide and its active metabolites are cleared by the kidneys, so they accumulate in CKD and can cause severe, prolonged hypoglycemia. Older adults are at greater risk. The prescriber is informed, and a different drug is usually chosen.
Answer
D · The drug and its metabolites build up and cause long lows
10.Lab values & electrolytes
Answer: A · Thalassemia trait
Why this is the answer
Thalassemia trait causes microcytosis from reduced globin production, often with a normal or high red cell count and normal ferritin. Iron deficiency has low ferritin. Iron supplements do not help thalassemia trait and can cause iron overload.
Answer
A · Thalassemia trait
11.Arterial blood gas interpretation
Answer: PaCO₂ = 26 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·12 + 8 = 26 mmHg
range: 24–28 mmHg
Answer
PaCO₂ = 26 mmHg
12.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·9 + 8 = 21.5 → 19.5–23.5 mmHg
Compare
measured: 28 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
13.ECG rhythm strip interpretation
Answer: QTc = 0.491 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 13 × 0.04 = 0.52 s
RR = 28 × 0.04 = 1.12 s
Bazett’s formula
QTc = 0.52/√1.12 = 0.52/1.058 = 0.491 s
Answer
QTc = 0.491 s
Above the usual limits for both men (about 0.45 s) and women (about 0.46 s): prolonged. (491 ms)
14.ECG rhythm strip interpretation
Answer: second-degree AV block type I (Wenckebach)
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: 5 QRS complexes in 6 s, × 10 = 50 per minute.
2. Rhythm: regularly irregular, the QRS complexes come in groups separated by a pause (group beating).
3. P waves: upright and regular (P–P 0.96 s, 63 per minute); one P in every 4 is not followed by a QRS.
4. PR interval: lengthens 0.18 → 0.30 → 0.36 s, then a P wave is not conducted.
5. QRS: 0.08 s, narrow (below 0.12 s).
Interpretation
second-degree AV block type I (Wenckebach)
Answer
second-degree AV block type I (Wenckebach)
15.Prioritization & delegation
Answer: D · The vomiting and fluid loss
Why this is the answer
Ongoing vomiting threatens fluid and electrolyte balance, a physiological need. Emotional support is important and should follow soon, but the physical threat is addressed first.
Answer
D · The vomiting and fluid loss
16.Prioritization & delegation
Answer: A · Large-volume IV fluids with close monitoring of urine output
Why this is the answer
Once the airway is secure, the early priority in major burns is fluid resuscitation to prevent burn shock. Urine output is a key guide to whether enough fluid is being given.
Answer
A · Large-volume IV fluids with close monitoring of urine output