Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which statement about direct oral anticoagulants such as apixaban and rivaroxaban is correct?
AMissed doses do not matter because they act for weeks
BTheir effect is reversed by giving vitamin K
CWeekly INR checks are needed, as with warfarin
DNo routine INR checks, but doses depend on kidney function
2.Med-surg: cardiovascular & respiratoryHard
A patient has been on continuous NIV via a full-face mask for two days. Which nursing measure helps prevent the most common complication?
ACheck mask fit and protect the bridge of the nose
BUse the same mask size for every patient
CRemove the mask for an hour each time the alarm sounds
DTighten the straps as far as they will go to stop any leak
3.Med-surg: neuro, endocrine & renalMedium
Which Glasgow Coma Scale score usually suggests that a patient may not be able to protect their own airway?
A13 or below
B11 or above
C8 or below
D15
4.Med-surg: neuro, endocrine & renalHard
A patient on insulin has worsening chronic kidney disease and is having more hypos. What is the best explanation?
AThe kidneys clear less insulin, so it lasts longer
BKidney disease makes the meter read too low
CKidney disease makes the body resistant to insulin
DThe patient is eating far more carbohydrate than before
5.Med-surg: GI, perioperative & oncologyMedium
Which risk is particularly linked with tramadol?
AHigh blood pressure that needs emergency treatment in most patients
BSevere stomach ulcers in all patients
CSerotonin syndrome with some antidepressants, and seizures
DRapid liver failure at normal doses
6.Med-surg: GI, perioperative & oncologyHard
Hours after an epidural catheter is removed, a patient on an anticoagulant develops back pain and worsening leg weakness. What should be suspected?
AAn epidural haematoma, needing emergency review and MRI
BA urinary tract infection causing back pain
CNormal wearing-off of the epidural block over the day
DA sacral pressure ulcer causing referred leg pain
7.Clinical nursingMedium
A patient is newly confused, has a respiratory rate of 24/min and a systolic blood pressure of 95 mmHg. What should you suspect first?
ASepsis
BNormal postoperative recovery
CAnxiety
DAlcohol intoxication
8.Clinical nursingHard
A patient due a blood transfusion is not wearing an identity band. What should the nurse do?
AAsk another patient to confirm who the patient is
BAsk the patient to state their name and date of birth, then start straight away
CNot start until a correct identity band is in place and identity is confirmed
DCheck the name on the bed and proceed
9.Lab values & electrolytesMedium
A patient with type 1 diabetes has the flu, is eating little and has a glucose of 290 mg/dL (16.1 mmol/L). Which advice is correct?
AWait 3 days before checking the glucose again
BStop all insulin until you are eating normally again
CDrink only water and avoid all carbohydrate foods
DKeep taking insulin and check blood or urine ketones
10.Lab values & electrolytesHard
A patient admitted with heavy alcohol use and malnutrition has a glucose of 52 mg/dL (2.9 mmol/L) and low magnesium. Which prescribed treatment should be given before the IV glucose?
AIV potassium
BIV thiamine
COral iron
DIV insulin
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 16 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 16 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 21% oxygen shows PaO₂ 70 mmHg (9.3 kPa) and PaCO₂ 52 mmHg (6.9 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1atrial fibrillation
2accelerated junctional rhythm
3atrial flutter, 2:1 conduction
4supraventricular tachycardia (SVT)
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1atrial flutter, 2:1 conduction
2supraventricular tachycardia (SVT)
3torsades de pointes
4ventricular fibrillation
15.Prioritization & delegationMedium
During labor, the nurse sees the umbilical cord in the vagina after the membranes rupture. What is the first action?
APush the cord back into the uterus
BAsk the patient to walk around the room to bring the baby lower and speed up labor
CWait for the next contraction before acting
DRelieve pressure on the cord by lifting the presenting part with a gloved hand
16.Prioritization & delegationHard
Four patients arrive at the emergency department at the same time. Who should be seen first?
AA young adult with a swollen, painful ankle after a fall on the stairs
BA child with a temperature of 39 °C who is alert and drinking
CAn adult with kidney stone pain of 9/10 and stable vital signs
DAn older adult with weakness on one side that began 40 minutes ago
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · No routine INR checks, but doses depend on kidney function
Why this is the answer
DOACs have predictable effects, so routine coagulation monitoring is not required. Renal function, weight, age and interacting drugs guide dosing. Because the effect wears off within a day or two, missed doses matter. Vitamin K does not reverse them; specific reversal agents exist.
Answer
D · No routine INR checks, but doses depend on kidney function
2.Med-surg: cardiovascular & respiratory
Answer: A · Check mask fit and protect the bridge of the nose
Why this is the answer
Pressure injury over the bridge of the nose is common with NIV masks. Correctly sized masks, avoiding overtightening (allowing a small gap under the straps), protective dressings and regular skin checks reduce it. Other problems include eye irritation, dryness and gastric distension.
Answer
A · Check mask fit and protect the bridge of the nose
3.Med-surg: neuro, endocrine & renal
Answer: C · 8 or below
Why this is the answer
A GCS of 8 or less usually indicates coma and a risk that the patient cannot maintain or protect the airway, so urgent senior and anaesthetic review is needed. The score ranges from 3 to 15, and the components (E, V, M) should be reported separately.
Answer
C · 8 or below
4.Med-surg: neuro, endocrine & renal
Answer: A · The kidneys clear less insulin, so it lasts longer
Why this is the answer
The kidneys clear a large share of insulin. As kidney function falls, insulin stays in the blood longer and some oral agents build up, so hypos increase. Insulin doses often need to be reduced.
Answer
A · The kidneys clear less insulin, so it lasts longer
5.Med-surg: GI, perioperative & oncology
Answer: C · Serotonin syndrome with some antidepressants, and seizures
Why this is the answer
Tramadol is a weak opioid that also inhibits serotonin and noradrenaline reuptake. It can lower the seizure threshold and cause serotonin syndrome with SSRIs and other serotonergic drugs.
Answer
C · Serotonin syndrome with some antidepressants, and seizures
6.Med-surg: GI, perioperative & oncology
Answer: A · An epidural haematoma, needing emergency review and MRI
Why this is the answer
Increasing motor weakness, numbness, back pain or bladder dysfunction with an epidural or after removal, especially with anticoagulants, can indicate an epidural haematoma or abscess. It is an emergency: urgent anaesthetic review and MRI, with surgical decompression if needed, to prevent permanent paralysis.
Answer
A · An epidural haematoma, needing emergency review and MRI
7.Clinical nursing
Answer: A · Sepsis
Why this is the answer
These three signs form the qSOFA criteria and suggest a high risk of poor outcome from sepsis. Escalate urgently and start the sepsis pathway.
Answer
A · Sepsis
8.Clinical nursing
Answer: C · Not start until a correct identity band is in place and identity is confirmed
Why this is the answer
Positive patient identification, using an identity band checked against the blood unit and prescription, is essential before every transfusion. Wrong blood incidents can cause fatal ABO incompatibility reactions.
Answer
C · Not start until a correct identity band is in place and identity is confirmed
9.Lab values & electrolytes
Answer: D · Keep taking insulin and check blood or urine ketones
Why this is the answer
During illness, stress hormones raise glucose, so insulin is continued even when eating less. Glucose and ketones are checked often, fluids are taken, and the provider is contacted if ketones are moderate or high or vomiting prevents fluids.
Answer
D · Keep taking insulin and check blood or urine ketones
10.Lab values & electrolytes
Answer: B · IV thiamine
Why this is the answer
People with alcohol use disorder and malnutrition are often deficient in thiamine. Giving glucose first can use up the remaining thiamine and precipitate Wernicke encephalopathy, so thiamine is usually given before or with glucose. Hypoglycemia must still be treated promptly.
Answer
B · IV thiamine
11.Arterial blood gas interpretation
Answer: PaCO₂ = 32 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·16 + 8 = 32 mmHg
range: 30–34 mmHg
Answer
PaCO₂ = 32 mmHg
12.Arterial blood gas interpretation
Answer: A–a gradient = 14.73 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC. Narrow-complex tachycardia and pauses: supraventricular tachycardia (SVT) is a regular tachycardia at about 150–250/min with narrow QRS complexes; the P waves are usually not visible because they are hidden in the QRS complex or the T wave. Sinus tachycardia in an adult at rest is usually below about 150/min and has a visible P wave before every QRS; atrial flutter with 2:1 conduction often runs at about 150/min and shows sawtooth waves. In sinus arrest the sinus node stops firing for a moment: a pause with no P wave and no QRS whose length is not a whole number of P–P cycles (a pause of exactly two or three cycles points to sinus exit block instead).
Five steps
1. Rate: R–R = 9 small boxes, 1500 ÷ 9 ≈ 167 per minute.
2. Rhythm: regular, every R–R is 0.36 s.
3. P waves: none visible; at this rate they are hidden in the QRS complexes or the T waves.
4. PR interval: not measurable.
5. QRS: 0.08 s, narrow (below 0.12 s), so the rhythm starts above the ventricles.
Interpretation
supraventricular tachycardia (SVT)
Answer
supraventricular tachycardia (SVT)
14.ECG rhythm strip interpretation
Answer: torsades de pointes
More ventricular rhythms: torsades de pointes is a polymorphic ventricular tachycardia, usually 150–250/min, in which the wide complexes change in height and twist around the baseline, pointing up for a few beats and then down. Textbooks link it to a prolonged QT interval, and magnesium sulfate is the drug resuscitation guidelines name for it. An idioventricular rhythm is a ventricular escape rhythm: regular, wide QRS (0.12 s or more), no P waves, at 20–40/min (an accelerated idioventricular rhythm runs at 40–100/min). Monomorphic VT has identical wide complexes at more than 100/min. VF is chaotic, without any repeating complex.
Five steps
1. Rate: very fast, the complexes are about 6 small boxes apart (about 250 per minute).
2. Rhythm: fast and roughly regular, but the height and direction of the complexes change in a repeating spindle pattern.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: wide and polymorphic; the complexes twist around the baseline, pointing up for a few beats and then down.
Interpretation
torsades de pointes
Answer
torsades de pointes
Torsades de pointes is a polymorphic VT linked to a prolonged QT interval. This is identification practice only.
15.Prioritization & delegation
Answer: D · Relieve pressure on the cord by lifting the presenting part with a gloved hand
Why this is the answer
In cord prolapse, the presenting part can compress the cord and cut off fetal oxygen. The nurse lifts the presenting part off the cord, calls for help and positions the patient (for example knee-chest) while urgent birth is arranged.
Answer
D · Relieve pressure on the cord by lifting the presenting part with a gloved hand
16.Prioritization & delegation
Answer: D · An older adult with weakness on one side that began 40 minutes ago
Why this is the answer
Sudden one-sided weakness suggests a stroke, and treatment depends on how quickly it starts. Severe kidney stone pain needs prompt pain relief, but the patient is stable.
Answer
D · An older adult with weakness on one side that began 40 minutes ago