Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
What is the ejection fraction?
AThe volume of blood pumped out with each heartbeat
BThe percentage of ventricular blood ejected with each beat
CThe volume of blood the heart pumps out every minute
DThe pressure in the left ventricle at the end of diastolic filling
2.Med-surg: cardiovascular & respiratoryHard
A patient taking warfarin for AF falls and hits their head. An hour later they are drowsy and have vomited. What is the priority?
AGive paracetamol (acetaminophen) and a light meal
BUrgent escalation for CT of the head and anticoagulant reversal
CWithhold tonight's warfarin and review tomorrow
DEncourage sleep and check observations at the next routine time
3.Med-surg: neuro, endocrine & renalMedium
A patient on insulin asks about drinking alcohol. Which advice is correct?
AAlcohol has no effect on blood glucose in people with diabetes
BAlcohol can cause hypos, even the next day, so eat carbs with it
CAlcohol should replace a meal on the days it is drunk
DAlcohol raises glucose, so extra insulin should be taken first
4.Med-surg: neuro, endocrine & renalHard
A patient with Parkinson's disease is nil by mouth after abdominal surgery. Their levodopa is due. What is the best action?
AGive double the dose once eating restarts
BContact the prescriber or pharmacist about another route
COmit the dose until the patient can swallow again
DGive the tablets with a sip of water anyway
5.Med-surg: GI, perioperative & oncologyMedium
Before an anti-TNF biologic such as infliximab is started for Crohn's disease, which screening is essential?
AA test for coeliac disease
BScreening for tuberculosis
CA test of colour vision
DA bone density scan
6.Med-surg: GI, perioperative & oncologyHard
A patient with small bowel obstruction has a nasogastric tube draining 2 L a day. Which nursing focus is most important?
ARemoving the tube once 1 L has drained to prevent losses
BGiving oral fluids freely to replace what the tube removes
CAccurate fluid balance with IV replacement and electrolyte checks
DClamping the tube for long periods to save the stomach fluid
7.Clinical nursingMedium
Which measure helps reduce the risk of surgical site infection?
ALeaving the patient cool during surgery to slow bacterial growth
BChanging the wound dressing every hour
CRemoving hair, if needed, with clippers rather than a razor
DShaving the area with a razor the night before surgery
8.Clinical nursingHard
A patient with known cirrhosis suddenly vomits large amounts of bright red blood and becomes tachycardic. What is the most likely cause?
AA Mallory-Weiss tear from a small amount of vomiting
BBleeding from ruptured oesophageal varices
CSwallowed blood from a nosebleed
DA lower GI bleed from diverticular disease
9.Lab values & electrolytesMedium
A patient has taken hydrochlorothiazide for several years. Which laboratory change is a recognized effect of this drug?
AA fall in blood glucose
BA rise in serum potassium
CA rise in serum uric acid
DA fall in serum calcium
10.Lab values & electrolytesHard
Which finding most strongly suggests that a patient’s raised creatinine is due to acute kidney injury rather than long-standing chronic kidney disease?
AThe patient has long-standing anemia
BThe creatinine was normal three days ago and has doubled since
CThe patient has had a high creatinine for many years
DThe patient has small kidneys on an ultrasound scan
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 18 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 18 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 144, Cl⁻ 106, HCO₃⁻ 19 mmol/L and albumin 15 g/L. Find the albumin-corrected anion gap AGc = AG + 0.25·(40 − albumin).
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus bradycardia
2third-degree (complete) AV block
3idioventricular rhythm
4asystole
15.Prioritization & delegationMedium
Two nursing assistants argue loudly at the station about their assignments. What is the charge nurse’s best first step?
AMeet both of them privately to hear each side
BIgnore it and hope they sort it out
CReport them to human resources at once
DChange both of their assignments without any discussion
16.Prioritization & delegationHard
Weeks after a kidney transplant, a patient has a fever, less urine and tenderness over the new kidney. What should the nurse suspect?
ANormal healing of the transplant
BA side effect of eating salty food
CDehydration from drinking too much
DRejection of the transplant
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · The percentage of ventricular blood ejected with each beat
Why this is the answer
Ejection fraction = stroke volume ÷ end-diastolic volume, normally about 50–70%. Heart failure with reduced ejection fraction is usually defined as 40% or less. Cardiac output is the volume per minute and stroke volume the volume per beat.
Answer
B · The percentage of ventricular blood ejected with each beat
2.Med-surg: cardiovascular & respiratory
Answer: B · Urgent escalation for CT of the head and anticoagulant reversal
Why this is the answer
Head injury in an anticoagulated patient with drowsiness or vomiting suggests intracranial haemorrhage. Urgent CT, neurological observations, an INR and rapid reversal (for warfarin, prothrombin complex concentrate and IV vitamin K) are needed.
Answer
B · Urgent escalation for CT of the head and anticoagulant reversal
3.Med-surg: neuro, endocrine & renal
Answer: B · Alcohol can cause hypos, even the next day, so eat carbs with it
Why this is the answer
Alcohol reduces the liver's release of glucose, so it increases the risk of hypoglycaemia, which may be delayed for many hours. Patients should eat carbohydrate, check glucose before bed and tell friends that a hypo can look like drunkenness.
Answer
B · Alcohol can cause hypos, even the next day, so eat carbs with it
4.Med-surg: neuro, endocrine & renal
Answer: B · Contact the prescriber or pharmacist about another route
Why this is the answer
Omitting Parkinson's medication can cause severe rigidity, swallowing failure and, rarely, a life-threatening withdrawal syndrome. Alternatives such as giving it by nasogastric tube or a dopamine agonist patch should be arranged urgently.
Answer
B · Contact the prescriber or pharmacist about another route
5.Med-surg: GI, perioperative & oncology
Answer: B · Screening for tuberculosis
Why this is the answer
Anti-TNF drugs suppress immunity and can reactivate latent tuberculosis. Patients are screened for TB and hepatitis B before starting and are taught to report signs of infection.
Answer
B · Screening for tuberculosis
6.Med-surg: GI, perioperative & oncology
Answer: C · Accurate fluid balance with IV replacement and electrolyte checks
Why this is the answer
Large NG losses cause dehydration, hypokalaemia and a hypochloraemic metabolic alkalosis. The aspirate is measured and recorded, replaced IV as prescribed (often with potassium-containing crystalloid), and urea, creatinine and electrolytes are checked at least daily. Oral fluids would increase the losses and vomiting risk.
Answer
C · Accurate fluid balance with IV replacement and electrolyte checks
7.Clinical nursing
Answer: C · Removing hair, if needed, with clippers rather than a razor
Why this is the answer
Razors cause micro-abrasions that increase infection risk, so hair is removed only if necessary with clippers just before surgery. Keeping patients warm and good skin preparation also help.
Answer
C · Removing hair, if needed, with clippers rather than a razor
8.Clinical nursing
Answer: B · Bleeding from ruptured oesophageal varices
Why this is the answer
Portal hypertension in cirrhosis causes oesophageal varices, which can bleed massively. This needs resuscitation, urgent endoscopy and specific drug treatment.
Answer
B · Bleeding from ruptured oesophageal varices
9.Lab values & electrolytes
Answer: C · A rise in serum uric acid
Why this is the answer
Thiazides reduce uric acid excretion and can trigger gout. They also tend to lower potassium, sodium and magnesium, raise calcium (by reducing its excretion) and raise blood glucose and lipids.
Answer
C · A rise in serum uric acid
10.Lab values & electrolytes
Answer: B · The creatinine was normal three days ago and has doubled since
Why this is the answer
A rapid rise from a normal baseline over days is the hallmark of acute kidney injury. Long-standing raised values, small kidneys and chronic anemia point to chronic kidney disease.
Answer
B · The creatinine was normal three days ago and has doubled since
11.Arterial blood gas interpretation
Answer: PaCO₂ = 35 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·18 + 8 = 35 mmHg
range: 33–37 mmHg
Answer
PaCO₂ = 35 mmHg
12.Arterial blood gas interpretation
Answer: AGc = 25.25 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 144 − (106 + 19) = 19
Correction for albumin
19 + 0.25·(40 − 15) = 25.25 mmol/L
Answer
AGc = 25.25 mmol/L
Above about 12 after correction: a high anion gap.
13.ECG rhythm strip interpretation
Answer: QTc = 0.426 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 10 × 0.04 = 0.40 s
RR = 22 × 0.04 = 0.88 s
Bazett’s formula
QTc = 0.40/√0.88 = 0.40/0.9381 = 0.426 s
Answer
QTc = 0.426 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (426 ms)
14.ECG rhythm strip interpretation
Answer: idioventricular rhythm
More ventricular rhythms: torsades de pointes is a polymorphic ventricular tachycardia, usually 150–250/min, in which the wide complexes change in height and twist around the baseline, pointing up for a few beats and then down. Textbooks link it to a prolonged QT interval, and magnesium sulfate is the drug resuscitation guidelines name for it. An idioventricular rhythm is a ventricular escape rhythm: regular, wide QRS (0.12 s or more), no P waves, at 20–40/min (an accelerated idioventricular rhythm runs at 40–100/min). Monomorphic VT has identical wide complexes at more than 100/min. VF is chaotic, without any repeating complex.
Five steps
1. Rate: R–R = 38 small boxes, 1500 ÷ 38 ≈ 39 per minute.
2. Rhythm: regular, every R–R is 1.52 s.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: 0.18 s, wide (0.12 s or more) and bizarre, with the T wave pointing the other way.
Interpretation
idioventricular rhythm
Answer
idioventricular rhythm
An idioventricular rhythm is an escape rhythm: the ventricles take over because the pacemakers above them have failed.
15.Prioritization & delegation
Answer: A · Meet both of them privately to hear each side
Why this is the answer
Talking with both staff members privately allows the charge nurse to understand the problem and look for a fair solution. Ignoring the conflict or acting without facts usually makes it worse.
Answer
A · Meet both of them privately to hear each side
16.Prioritization & delegation
Answer: D · Rejection of the transplant
Why this is the answer
Fever, falling urine output and graft tenderness are signs of possible rejection. The nurse reports promptly, because early treatment can save the kidney.