Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which exercise advice is recommended for intermittent claudication?
ASupervised walking until pain is near maximal, then rest and repeat
BWalking only on days when the legs feel warm and painless
CComplete bed rest until the leg pain has gone for at least a month
DStopping walking at the very first twinge of pain each time
2.Med-surg: cardiovascular & respiratoryHard
After positive end-expiratory pressure (PEEP) is increased on a ventilated patient, the blood pressure falls. What is the most likely reason?
APEEP directly weakens the heart muscle and its contraction
BPEEP causes immediate blood loss from the alveolar capillaries
CPEEP lowers the blood oxygen level
DHigher chest pressure reduces venous return to the heart
3.Med-surg: neuro, endocrine & renalMedium
An 85-year-old care home resident becomes newly confused and is falling more often. A UTI is one possibility. Why?
AOlder adults often show infection as confusion
BA UTI cannot occur in people over 80
CUrinary infections always cause a high fever in older adults
DConfusion is the only symptom of a UTI at any age
4.Med-surg: neuro, endocrine & renalHard
A patient has fever, confusion, odd behaviour and a new seizure. Herpes simplex encephalitis is suspected. Which drug is usually started straight away?
AIV insulin
BIV aciclovir
COral prednisolone
DOral amoxicillin
5.Med-surg: GI, perioperative & oncologyMedium
How can low-dose opioids help a patient with breathlessness from advanced cancer?
AThey open the airways like an inhaler
BThey increase the oxygen level in the blood
CThey cure the underlying lung disease
DThey reduce the feeling of breathlessness
6.Med-surg: GI, perioperative & oncologyHard
A patient rescued from a house fire has SpO₂ 99% on air but a headache, confusion and cherry-red lips. What should the nurse do?
AGive 100% oxygen by non-rebreather and request a carboxyhaemoglobin level
BRemove the oxygen, because the oxygen saturation is completely normal
CGive oxygen at 2 L/min by nasal cannula and recheck in an hour
DTreat the headache with paracetamol and observe the patient overnight
7.Clinical nursingMedium
A patient on a ward develops wheeze and breathlessness after the first dose of a beta-blocker. Which history makes this most likely?
AAsthma
BOsteoarthritis
CHypothyroidism
DMigraine
8.Clinical nursingHard
Which ECG change is classically associated with severe hyperkalaemia?
ATall, peaked T waves
BProminent U waves
CA shortened PR interval
DST depression only
9.Lab values & electrolytesMedium
A patient with HIV on antiretroviral therapy has an undetectable viral load. What does this mean?
AThe treatment is suppressing the virus very well
BThe treatment can now be stopped without any risk
CThe CD4 count must now be dangerously low too
DThe virus has been completely cured and removed
10.Lab values & electrolytesHard
A stable patient's hemoglobin has been 13–14 g/dL for days. Today's result is 8.2 g/dL, but the patient feels well, the vital signs are normal and there is no bleeding. What should the nurse suspect first?
AA sample taken from the wrong patient
BAcute bone marrow failure overnight
CA normal day-to-day variation in Hb
DSudden massive internal bleeding
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.36, PaCO₂ 22 mmHg (2.9 kPa) and HCO₃⁻ 12 mmol/L. The primary disorder is metabolic acidosis. How far is it compensated? Click your answer.
pH 7.36PaCO₂ 22 mmHg (2.9 kPa)HCO₃⁻ 12 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 40% oxygen shows PaO₂ 64 mmHg (8.5 kPa) and PaCO₂ 33 mmHg (4.4 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows an AV block, so the atria and the ventricles beat at different rates. Measure the P–P interval and find the atrial rate in beats per minute (1500 method, whole number).
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
atrial rate = bpm
15.Prioritization & delegationMedium
Which medication order should the nurse question?
APotassium chloride by IV push
BOral potassium chloride with food
CPotassium chloride diluted in an IV bag via a pump
DPotassium chloride oral solution diluted in juice
16.Prioritization & delegationHard
Using ESI, a stable adult with abdominal pain will need blood tests and a CT scan, but has a heart rate of 130/min. Which statement is correct?
AVital signs never change the ESI level
BThe patient is level 4 because the blood tests and the scan count as one resource
CThe nurse should consider level 2 because of the danger-zone vital sign
DThe patient is level 5 because the pain is not severe
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · Supervised walking until pain is near maximal, then rest and repeat
Why this is the answer
Supervised exercise programmes, walking to near-maximal claudication pain, resting and repeating for about 30 minutes several times a week, improve walking distance. With smoking cessation, an antiplatelet and a statin, this is first-line management.
Answer
A · Supervised walking until pain is near maximal, then rest and repeat
2.Med-surg: cardiovascular & respiratory
Answer: D · Higher chest pressure reduces venous return to the heart
Why this is the answer
PEEP keeps alveoli open and improves oxygenation, but higher intrathoracic pressure impedes venous return, reducing preload and cardiac output, especially in hypovolaemic patients. The team may give fluid or adjust PEEP. High pressures also risk barotrauma.
Answer
D · Higher chest pressure reduces venous return to the heart
3.Med-surg: neuro, endocrine & renal
Answer: A · Older adults often show infection as confusion
Why this is the answer
In older adults, infections such as UTI may present with delirium, falls or reduced mobility rather than dysuria or fever. Other causes of delirium must also be considered, and urine tests alone can mislead.
Answer
A · Older adults often show infection as confusion
4.Med-surg: neuro, endocrine & renal
Answer: B · IV aciclovir
Why this is the answer
Herpes simplex encephalitis is treatable but can cause severe brain damage. IV aciclovir is started as soon as it is suspected, without waiting for test results. Kidney function and hydration are monitored during treatment.
Answer
B · IV aciclovir
5.Med-surg: GI, perioperative & oncology
Answer: D · They reduce the feeling of breathlessness
Why this is the answer
In palliative care, low-dose opioids reduce the sensation of breathlessness and the anxiety it causes. Fans, positioning, relaxation and treating reversible causes are also used.
Answer
D · They reduce the feeling of breathlessness
6.Med-surg: GI, perioperative & oncology
Answer: A · Give 100% oxygen by non-rebreather and request a carboxyhaemoglobin level
Why this is the answer
Carbon monoxide binds haemoglobin more strongly than oxygen. Standard pulse oximetry reads carboxyhaemoglobin as oxyhaemoglobin, so SpO₂ may look normal. High-concentration oxygen speeds CO elimination. A co-oximetry blood gas measures carboxyhaemoglobin.
Answer
A · Give 100% oxygen by non-rebreather and request a carboxyhaemoglobin level
7.Clinical nursing
Answer: A · Asthma
Why this is the answer
Non-selective and even cardioselective beta-blockers can cause bronchospasm, so they are usually avoided in asthma.
Answer
A · Asthma
8.Clinical nursing
Answer: A · Tall, peaked T waves
Why this is the answer
Hyperkalaemia causes peaked T waves, then a widened QRS and possibly a sine-wave pattern and arrest. Hypokalaemia causes flat T waves and U waves.
Answer
A · Tall, peaked T waves
9.Lab values & electrolytes
Answer: A · The treatment is suppressing the virus very well
Why this is the answer
An undetectable viral load shows that antiretroviral therapy is suppressing viral replication. The virus remains in the body, so treatment must continue. People with a sustained undetectable viral load do not transmit HIV sexually.
Answer
A · The treatment is suppressing the virus very well
10.Lab values & electrolytes
Answer: A · A sample taken from the wrong patient
Why this is the answer
A sudden large change with no clinical change suggests a specimen error, such as wrong blood in the tube or dilution with IV fluid. The nurse assesses the patient, informs the provider and arranges a repeat sample with careful identification, while staying alert for true bleeding.
Answer
A · A sample taken from the wrong patient
11.Arterial blood gas interpretation
Answer: fully compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.36: within 7.35–7.45
PaCO₂ 22 mmHg: low (35–45)
HCO₃⁻ 12 mmol/L: low (22–26)
Compensation
Clinically, also check the expected compensation: Winter’s formula expects PaCO₂ 24–28 mmHg, so the measured 22 mmHg points to an additional respiratory alkalosis (a mixed disorder). The answer above is the ROME exam classification.
fully compensated
Answer
fully compensated
12.Arterial blood gas interpretation
Answer: A–a gradient = 179.9 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9.5 × 0.04 = 0.38 s
RR = 19 × 0.04 = 0.76 s
Bazett’s formula
QTc = 0.38/√0.76 = 0.38/0.8718 = 0.436 s
Answer
QTc = 0.436 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (436 ms)
14.ECG rhythm strip interpretation
Answer: atrial rate = 68 bpm
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Atrial rate
P–P = 22 small boxes = 0.88 s → 1500 ÷ 22 = 68.18 ≈ 68 per minute
Ventricular rate
R–R = 44 small boxes = 1.76 s → 1500 ÷ 44 = 34.09 ≈ 34 per minute
Answer
atrial rate = 68 bpm
Answer
atrial rate = 68 bpm
2:1 AV block: every second P wave is not conducted, so the atrial rate is twice the ventricular rate.
15.Prioritization & delegation
Answer: A · Potassium chloride by IV push
Why this is the answer
Potassium chloride must never be given by IV push, because a rapid dose can cause cardiac arrest. It is diluted and given slowly through an infusion pump.
Answer
A · Potassium chloride by IV push
16.Prioritization & delegation
Answer: C · The nurse should consider level 2 because of the danger-zone vital sign
Why this is the answer
In ESI, a patient who needs two or more resources is level 3, but danger-zone vital signs such as a very fast heart rate should make the nurse consider level 2.
Answer
C · The nurse should consider level 2 because of the danger-zone vital sign