Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Why is active tuberculosis treated with several drugs for at least six months?
ATo kill slow-growing bacteria and prevent drug resistance
BTo reduce the number of side effects compared with one drug
CBecause each drug works on a different organ only
DBecause the bacteria are resistant to all drugs at first
2.Med-surg: cardiovascular & respiratoryHard
A patient with pneumonia on high-flow nasal oxygen at 50 L/min with FiO₂ 0.6 has SpO₂ 90%, RR 34/min and is using accessory muscles. What is the most appropriate action?
AContinue the same support and recheck in four hours
BEscalate urgently to critical care for review of respiratory support
CChange to a nasal cannula at 4 L/min to reduce nasal dryness
DLay the patient flat so they can rest the breathing muscles
3.Med-surg: neuro, endocrine & renalMedium
A patient with a new ileal conduit has threads of mucus in their urine. What should the nurse explain?
AThis is normal, because the conduit is made from bowel
BThis is a sign that the stoma is dying
CThis proves a serious kidney infection
DThe kidneys have stopped working properly after surgery
4.Med-surg: neuro, endocrine & renalHard
The day after a lumbar puncture, a patient has a headache that is severe when standing and almost gone when lying flat. Temperature and neck movement are normal. What is the most likely cause?
AA subarachnoid haemorrhage
BA migraine triggered by stress
CPost-dural puncture headache
DBacterial meningitis from the procedure
5.Med-surg: GI, perioperative & oncologyMedium
Why does a patient need lifelong vitamin B12 injections after total gastrectomy?
AIntrinsic factor from the stomach is no longer made
BThe small bowel stops absorbing all nutrients
CThe liver can no longer store any vitamins
DVitamin B12 is lost in the urine after the surgery
6.Med-surg: GI, perioperative & oncologyHard
Two hours after a meal, a patient who had a gastrectomy becomes shaky, sweaty and confused. What is the most likely cause and first action?
ALate dumping with low blood glucose; check capillary glucose
BAn anastomotic leak; insert a nasogastric tube at once
CVitamin B12 deficiency; give an injection now
DEarly dumping from fluid shifts; give a large drink of water
7.Clinical nursingMedium
Why are patients advised to rinse their mouth after using an inhaled corticosteroid?
ATo reduce the risk of oral thrush
BTo stop the drug from being absorbed in the lungs
CTo make the drug work faster
DTo prevent tooth decay from the sugar in it
8.Clinical nursingHard
A patient with acute pancreatitis is in severe epigastric pain radiating to the back. Which nursing care is most important?
AStrict bed rest without observations
BAdequate pain relief, IV fluids and close fluid balance monitoring
CRestricting all fluids
DA large fatty meal to stimulate the pancreas
9.Lab values & electrolytesMedium
A stable adult who is not bleeding receives one unit of packed red cells. By about how much is the hemoglobin expected to rise?
AAbout 0.1 g/dL (1 g/L)
BAbout 1 g/dL (10 g/L)
CAbout 5 g/dL (50 g/L)
DAbout 3 g/dL (30 g/L)
10.Lab values & electrolytesHard
Why can an HbA1c result be misleading in a patient who received a large blood transfusion two weeks ago?
AHbA1c measures sugar on white cells, not red cells
BTransfusions always raise HbA1c to falsely high levels
CHbA1c is accurate in every situation
DMany red cells are donor cells, not exposed to the patient’s glucose
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 12 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 12 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 33 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 33 mmol/L
PaCO₂ = mmHg
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Interpret this lead II strip with the five steps in order: rate, rhythm, P waves, PR interval, QRS duration. At which step do you find the first abnormal finding? Click it.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1rate
2rhythm
3P waves
4PR interval
5QRS duration
15.Prioritization & delegationMedium
An older adult asks for something to help them sleep. Which drug is most likely to cause confusion and falls in this age group?
AAcetaminophen (paracetamol)
BMelatonin
CA warm milky drink
DDiphenhydramine
16.Prioritization & delegationHard
At 08:00 a nurse has four tasks. Which order is best?
AGive routine medications, check the patient with a falling SpO₂, update care plans, give insulin with breakfast
BUpdate care plans, give insulin with breakfast, give routine medications, check the patient with a falling SpO₂
CCheck the patient with a falling SpO₂, give insulin with breakfast, give routine medications, update care plans
DGive insulin with breakfast, update care plans, check the patient with a falling SpO₂, give routine medications
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · To kill slow-growing bacteria and prevent drug resistance
Why this is the answer
Mycobacterium tuberculosis grows slowly and has resistant mutants in any large population. A combination (for example rifampicin, isoniazid, pyrazinamide and ethambutol at first) kills susceptible and resistant bacteria and prevents resistance. Stopping early risks relapse and multidrug-resistant TB.
Answer
A · To kill slow-growing bacteria and prevent drug resistance
2.Med-surg: cardiovascular & respiratory
Answer: B · Escalate urgently to critical care for review of respiratory support
Why this is the answer
High oxygen requirements with tachypnoea and increased work of breathing despite high-flow oxygen indicate worsening respiratory failure. Early critical care review is needed for escalation such as CPAP, NIV or intubation. Reducing support or waiting risks a respiratory arrest.
Answer
B · Escalate urgently to critical care for review of respiratory support
3.Med-surg: neuro, endocrine & renal
Answer: A · This is normal, because the conduit is made from bowel
Why this is the answer
An ileal conduit uses a piece of small bowel, which keeps making mucus. Mucus in the urine is expected. Good fluid intake helps keep it moving. Fever, cloudy foul urine or a change in stoma colour should be reported.
Answer
A · This is normal, because the conduit is made from bowel
4.Med-surg: neuro, endocrine & renal
Answer: C · Post-dural puncture headache
Why this is the answer
A positional headache after a lumbar puncture, without fever or neck stiffness, fits a CSF leak. It is managed with rest, fluids, analgesia and caffeine, and an epidural blood patch if it persists. Fever or neck stiffness would suggest infection instead.
Answer
C · Post-dural puncture headache
5.Med-surg: GI, perioperative & oncology
Answer: A · Intrinsic factor from the stomach is no longer made
Why this is the answer
Parietal cells of the stomach make intrinsic factor, which is needed for B12 absorption in the terminal ileum. Without it, pernicious-type anaemia and neuropathy develop unless B12 is given by injection.
Answer
A · Intrinsic factor from the stomach is no longer made
6.Med-surg: GI, perioperative & oncology
Answer: A · Late dumping with low blood glucose; check capillary glucose
Why this is the answer
In late dumping, rapid sugar absorption triggers a large insulin release, followed by reactive hypoglycaemia 1–3 hours after eating. The nurse checks glucose and treats hypoglycaemia; dietary changes help prevent it.
Answer
A · Late dumping with low blood glucose; check capillary glucose
7.Clinical nursing
Answer: A · To reduce the risk of oral thrush
Why this is the answer
Inhaled steroid deposited in the mouth and throat can cause oral candidiasis and a hoarse voice. Rinsing and using a spacer reduce this.
Answer
A · To reduce the risk of oral thrush
8.Clinical nursing
Answer: B · Adequate pain relief, IV fluids and close fluid balance monitoring
Why this is the answer
Acute pancreatitis can cause large fluid losses and organ failure. Care focuses on fluid resuscitation, analgesia, monitoring urine output, glucose and early nutrition when possible.
Answer
B · Adequate pain relief, IV fluids and close fluid balance monitoring
9.Lab values & electrolytes
Answer: B · About 1 g/dL (10 g/L)
Why this is the answer
In an average-sized adult without ongoing bleeding or hemolysis, one unit of red cells raises the hemoglobin by about 1 g/dL (and the hematocrit by about 3%). A smaller rise suggests ongoing blood loss or red cell destruction.Checked against:Blood Transfusion · StatPearls (NCBI Bookshelf) (2026)
Answer
B · About 1 g/dL (10 g/L)
10.Lab values & electrolytes
Answer: D · Many red cells are donor cells, not exposed to the patient’s glucose
Why this is the answer
HbA1c forms as glucose attaches to hemoglobin over the life of a red cell. Transfused donor cells and conditions that shorten red cell life give falsely low values, so a glucose log or other markers are used instead.
Answer
D · Many red cells are donor cells, not exposed to the patient’s glucose
11.Arterial blood gas interpretation
Answer: PaCO₂ = 26 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·12 + 8 = 26 mmHg
range: 24–28 mmHg
Answer
PaCO₂ = 26 mmHg
12.Arterial blood gas interpretation
Answer: PaCO₂ = 44.1 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·33 + 21 = 44.1 mmHg
Answer
PaCO₂ = 44.1 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
13.ECG rhythm strip interpretation
Answer: QTc = 0.38 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9.5 × 0.04 = 0.38 s
RR = 25 × 0.04 = 1.00 s
Bazett’s formula
QTc = 0.38/√1.00 = 0.38/1 = 0.38 s
Answer
QTc = 0.38 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (380 ms)
14.ECG rhythm strip interpretation
Answer: P waves
Five steps for every strip: 1. rate (300 or 1500 method, or the 6-second method if irregular); 2. rhythm: are the R–R intervals equal; 3. P waves: present, upright in lead II, one before every QRS and all alike; 4. PR interval: 0.12–0.20 s and constant; 5. QRS duration: below 0.12 s. Only after the five steps name the rhythm. Normal sinus rhythm passes all five: 60–100/min, regular, upright P before every QRS, PR 0.12–0.20 s, QRS below 0.12 s.
Five steps
1. Rate: R–R = 17 small boxes, 1500 ÷ 17 ≈ 88 per minute.
2. Rhythm: regular, every R–R is 0.68 s.
3. P waves: inverted, just after each QRS.
4. PR interval: not measurable.
5. QRS: 0.08 s, narrow (below 0.12 s).
First abnormal step
P waves → accelerated junctional rhythm
Answer
P waves
15.Prioritization & delegation
Answer: D · Diphenhydramine
Why this is the answer
Diphenhydramine is strongly anticholinergic and can cause confusion, urinary retention and falls in older adults. It is on lists of drugs to avoid in this group.
Answer
D · Diphenhydramine
16.Prioritization & delegation
Answer: C · Check the patient with a falling SpO₂, give insulin with breakfast, give routine medications, update care plans
Why this is the answer
A falling SpO₂ is a possible breathing problem and comes first. Insulin must be matched to the meal, routine medications have a time window, and documentation such as care plans comes last.
Answer
C · Check the patient with a falling SpO₂, give insulin with breakfast, give routine medications, update care plans