Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which history is a contraindication to thrombolysis for a STEMI?
AA previous appendicectomy many years ago
BA previous haemorrhagic stroke
CTreated high blood pressure
DMild asthma controlled with inhalers
2.Med-surg: cardiovascular & respiratoryHard
On day 2 after a surgical tracheostomy, the tube falls out. The patient is breathing but distressed. What should the nurse do first?
ALeave the patient alone while fetching a new tube
BCall for expert help and give oxygen to both the face and the stoma
CForce the tube back through the stoma immediately with firm pressure
DCover the stoma completely with a sealed dressing and wait for help
3.Med-surg: neuro, endocrine & renalMedium
A patient taking sodium valproate becomes tired and is vomiting, and the nurse notices yellowing of the eyes. What is the main concern?
ALiver toxicity from valproate
BA sign that the dose is too low
CA normal adjustment reaction to the drug
DDehydration from drinking too little
4.Med-surg: neuro, endocrine & renalHard
At 03:00 a patient's glucose is 3.6 mmol/L, but before breakfast it is high. They take a long-acting insulin in the evening. What should the nurse do?
AIgnore the night reading and act on the morning value only
BStop all insulin permanently and monitor glucose four-hourly
CTreat the low and report the pattern so the evening dose is reviewed
DGive extra insulin at 03:00 because the morning value will be high
5.Med-surg: GI, perioperative & oncologyMedium
For how long are special precautions often taken with body fluids after many chemotherapy drugs?
AFor a whole year
BOnly during the infusion
CThey are never needed
DCommonly about 48 hours
6.Med-surg: GI, perioperative & oncologyHard
Which management is generally recommended for stable, dry, intact black eschar on the heel of a patient with poor circulation?
ALeave it intact, offload the heel and refer for review
BRemove it with sharp debridement at the bedside today
CCover it with a tight compression bandage
DSoak it in water every day to soften it
7.Clinical nursingMedium
A patient with type 2 diabetes is acutely unwell, very dehydrated and has a blood glucose of 40 mmol/L without significant ketones. What is the most likely diagnosis?
AHyperosmolar hyperglycaemic state
BDiabetic ketoacidosis with dehydration
CHypoglycaemia
DDiabetes insipidus
8.Clinical nursingHard
A patient after a total hip replacement suddenly has severe hip pain, a shortened leg and the leg is rotated. What is the most likely complication?
ADislocation of the prosthesis
BUrinary retention
CWound infection
DDeep vein thrombosis in the calf
9.Lab values & electrolytesMedium
How does normal pregnancy usually affect serum creatinine?
AIt rises with every week
BIt falls, because GFR rises
CIt rises, because GFR falls
DIt stays exactly the same
10.Lab values & electrolytesHard
A patient on a heparin infusion has a platelet count that falls from 260 to 110 × 10³/µL on day 7. Which action is most appropriate?
AContinue the infusion and increase the rate as per protocol
BTake no action, because the count is still just above 100 × 10³/µL
CGive a platelet transfusion and continue the heparin
DReport it at once: heparin-induced thrombocytopenia is possible
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 140 mmol/L, glucose 25 mmol/L and urea 5.6 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 140 mmol/Lglucose 25 mmol/Lurea 5.6 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 30% oxygen shows PaO₂ 94 mmHg (12.5 kPa) and PaCO₂ 57 mmHg (7.6 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1normal sinus rhythm
2sinus tachycardia
3junctional rhythm
4sinus bradycardia
14.ECG rhythm strip interpretationHard
This lead II strip shows second-degree AV block type I (Wenckebach). By how much does the PR interval increase from the first to the second beat of a group (ΔPR), in seconds?
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
ΔPR = s
15.Prioritization & delegationMedium
A patient is raising his voice, pacing and clenching his fists. What should the nurse do first?
ATurn away and ignore the behavior
BApply physical restraints at once
CSpeak calmly, keep a safe distance and invite him to talk about what is wrong
DStand very close to him and tell him firmly and loudly to sit down and be quiet
16.Prioritization & delegationHard
Which patient finding after a total knee replacement needs the nurse’s action first?
APain of 4/10 when the physiotherapist bends the knee during the morning session
BA small amount of dried blood on the dressing
CSudden calf pain and swelling in the operated leg, with new breathlessness
DAsks for an ice pack to help with swelling around the knee
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · A previous haemorrhagic stroke
Why this is the answer
Absolute contraindications include any previous intracranial haemorrhage, recent ischaemic stroke, active internal bleeding, suspected aortic dissection and recent major trauma or surgery. Thrombolysis is used when primary PCI cannot be delivered in time.
Answer
B · A previous haemorrhagic stroke
2.Med-surg: cardiovascular & respiratory
Answer: B · Call for expert help and give oxygen to both the face and the stoma
Why this is the answer
In the first days after a tracheostomy, the tract is immature and the tube can easily be misplaced into the tissues. Emergency guidance is to call for an airway expert, apply oxygen to face and stoma and assess breathing. Reinsertion is done only by trained staff.
Answer
B · Call for expert help and give oxygen to both the face and the stoma
3.Med-surg: neuro, endocrine & renal
Answer: A · Liver toxicity from valproate
Why this is the answer
Valproate can cause serious liver injury, especially early in treatment. Jaundice, vomiting, lethargy or abdominal pain need urgent review and liver function tests. Pancreatitis is another rare but serious effect.
Answer
A · Liver toxicity from valproate
4.Med-surg: neuro, endocrine & renal
Answer: C · Treat the low and report the pattern so the evening dose is reviewed
Why this is the answer
Nocturnal hypoglycaemia must be treated. A high morning glucose after a night-time low may reflect rebound (the Somogyi effect) or a separate cause; in either case the evening insulin regimen needs review. Giving extra insulin at night would make the hypoglycaemia worse.
Answer
C · Treat the low and report the pattern so the evening dose is reviewed
5.Med-surg: GI, perioperative & oncology
Answer: D · Commonly about 48 hours
Why this is the answer
Many cytotoxic drugs are excreted in urine, faeces, vomit and other fluids for some time after administration. Local policies often require gloves and gowns for handling body fluids for about 48 hours, and longer for some drugs.
Answer
D · Commonly about 48 hours
6.Med-surg: GI, perioperative & oncology
Answer: A · Leave it intact, offload the heel and refer for review
Why this is the answer
Stable, dry eschar on an ischaemic heel acts as a biological barrier and should usually not be debrided. The heel is offloaded and the circulation assessed. If it becomes soft, boggy, red or draining, infection should be suspected and specialist review sought.
Answer
A · Leave it intact, offload the heel and refer for review
7.Clinical nursing
Answer: A · Hyperosmolar hyperglycaemic state
Why this is the answer
HHS usually affects people with type 2 diabetes. It develops over days with extreme hyperglycaemia, dehydration and high osmolality, but little ketosis.
Answer
A · Hyperosmolar hyperglycaemic state
8.Clinical nursing
Answer: A · Dislocation of the prosthesis
Why this is the answer
Hip dislocation after arthroplasty causes sudden pain, shortening and rotation. It needs urgent review and reduction; patients are taught movement precautions.
Answer
A · Dislocation of the prosthesis
9.Lab values & electrolytes
Answer: B · It falls, because GFR rises
Why this is the answer
In pregnancy, kidney blood flow and GFR rise by about 50%, so creatinine falls below non-pregnant values. A creatinine that looks "normal" for a non-pregnant adult may indicate reduced kidney function in pregnancy.
Answer
B · It falls, because GFR rises
10.Lab values & electrolytes
Answer: D · Report it at once: heparin-induced thrombocytopenia is possible
Why this is the answer
Heparin-induced thrombocytopenia causes a large fall in platelets (often more than half), usually 5–14 days after starting heparin, and carries a high risk of clots. The prescriber stops all heparin and starts a non-heparin anticoagulant if HIT is suspected.Checked against:Heparin-Induced Thrombocytopenia · StatPearls (NCBI Bookshelf) (2023)
Answer
D · Report it at once: heparin-induced thrombocytopenia is possible
11.Arterial blood gas interpretation
Answer: Osm = 311 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·140 + 25 + 5.6 = 310.6 ≈ 311 mOsm/kg
Answer
Osm = 311 mOsm/kg
12.Arterial blood gas interpretation
Answer: A–a gradient = 48.65 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 34 small boxes, 1500 ÷ 34 ≈ 44 per minute.
2. Rhythm: regular, every R–R is 1.36 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.16 s, constant, within 0.12–0.20 s.
5. QRS: 0.06 s, narrow (below 0.12 s).
Interpretation
sinus bradycardia
Answer
sinus bradycardia
14.ECG rhythm strip interpretation
Answer: ΔPR = 0.14 s
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
March out the P waves
P–P = 0.88 s, regular; one P wave in every 4 is not conducted
PR in each group
PR₁ = 0.18 s, PR₂ = 0.32 s, PR₃ = 0.38 s
Answer
ΔPR = 0.14 s
The biggest step in PR comes between the first and second beats of a group; later steps are smaller, which is why the R–R intervals shorten before the pause.
15.Prioritization & delegation
Answer: C · Speak calmly, keep a safe distance and invite him to talk about what is wrong
Why this is the answer
Early verbal de-escalation, with a calm voice and a safe distance, is the first approach for rising agitation. Restraint is a last resort, and crowding the patient can make things worse.
Answer
C · Speak calmly, keep a safe distance and invite him to talk about what is wrong
16.Prioritization & delegation
Answer: C · Sudden calf pain and swelling in the operated leg, with new breathlessness
Why this is the answer
Calf pain and swelling suggest deep vein thrombosis, and new breathlessness raises concern for a pulmonary embolism. This needs immediate assessment and escalation; the other findings are expected.
Answer
C · Sudden calf pain and swelling in the operated leg, with new breathlessness