Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
After repair of an abdominal aortic aneurysm, which regular assessment helps detect a blocked graft or clots in the legs?
AMeasuring the blood glucose every hour through the night
BTesting the gag reflex every four hours after surgery
CChecking leg pulses, colour, warmth and sensation
DChecking the pupils' response to light
2.Med-surg: cardiovascular & respiratoryHard
A patient with severe sepsis becomes increasingly breathless over 24 hours. SpO₂ stays low despite high-flow oxygen, and the chest X-ray shows bilateral infiltrates. The heart function is normal. Which condition is most likely?
AAcute left ventricular failure after an MI
BSpontaneous pneumothorax
CAn acute asthma attack
DAcute respiratory distress syndrome
3.Med-surg: neuro, endocrine & renalMedium
A patient has had a calcium oxalate kidney stone. Which advice best helps prevent another?
ADrink plenty of fluid so the urine stays pale
BDrink only a little to avoid diluting the urine
CTake extra vitamin C supplements
DCut all calcium out of the diet
4.Med-surg: neuro, endocrine & renalHard
A patient has episodes of severe headache, sweating, palpitations and very high blood pressure. Which condition should be considered?
ADiabetes insipidus
BHypothyroidism
CAddison's disease
DPhaeochromocytoma
5.Med-surg: GI, perioperative & oncologyMedium
After a percutaneous liver biopsy, how is the patient usually positioned at first?
AOn the right side, to press on the puncture site
BOn the left side, to drain the liver
CSitting upright, with the legs over the edge of the bed
DProne, with the head lower than the feet
6.Med-surg: GI, perioperative & oncologyHard
A patient with diabetes on continuous enteral feeding and an insulin regimen has the feed stopped for a procedure. What is the main concern?
ARefeeding syndrome from too much glucose
BDiarrhoea from stopping the feed suddenly
CHypoglycaemia if insulin continues without the feed
DHyperglycaemia because the stomach is empty
7.Clinical nursingMedium
Which lifestyle advice helps a patient with gastro-oesophageal reflux disease?
AAvoid large meals late in the evening and raise the head of the bed
BWear tight belts to support the stomach
CLie down straight after each meal to let the food settle
DEat one very large meal a day rather than several small ones
8.Clinical nursingHard
A patient on IV vancomycin develops flushing and an itchy red rash on the face and neck during a fast infusion. What is the most likely cause and response?
ALiver failure; stop all medicines permanently
BInfusion-related reaction; stop or slow the infusion and inform the prescriber
CSunburn; apply cream and continue
DNormal response; increase the infusion rate
9.Lab values & electrolytesMedium
In the third trimester of pregnancy, a woman's alkaline phosphatase (ALP) is about twice the usual adult range, and the other liver tests are normal. What is the best interpretation?
AA sign of new bone cancer
BA sign of blocked bile ducts
CA normal rise from placental ALP
DA sign of acute viral hepatitis
10.Lab values & electrolytesHard
The nurse teaches a patient with iron-deficiency anemia who is starting oral iron. Which statement shows a need for further teaching?
A"I'll take my iron tablet with a big glass of milk"
B"I can take it with orange juice to help absorption"
C"My stools may look darker while I take the tablets"
D"I'll keep the tablets out of reach of the children"
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 16 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 16 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 30% oxygen shows PaO₂ 67 mmHg (8.9 kPa) and PaCO₂ 44 mmHg (5.9 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
This lead II strip shows sinus rhythm with one pause. Measure the pause, the R–R interval across it, in seconds.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
pause = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1atrial fibrillation
2ventricular tachycardia
3torsades de pointes
4ventricular fibrillation
15.Prioritization & delegationMedium
Which patient should the RN see first after receiving a report from the night nurse?
ADay 4 after bowel surgery, waiting for discharge teaching
BDay 3 after bowel surgery, wants a shower and hair wash before breakfast
CDay 2 after bowel surgery, asking to start a soft diet
DDay 1 after bowel surgery, new chest pain and heart rate 110/min
16.Prioritization & delegationHard
An infant with pyloric stenosis has repeated projectile vomiting. Which acid-base imbalance is most likely?
AMetabolic alkalosis
BMetabolic acidosis
CRespiratory acidosis
DRespiratory alkalosis
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Checking leg pulses, colour, warmth and sensation
Why this is the answer
After aortic surgery, distal pulses, skin colour, temperature, capillary refill, movement and sensation are checked often and compared with baseline. Loss of pulses, pallor or pain suggests graft occlusion or emboli and must be reported at once. Urine output is also monitored for renal perfusion.
Answer
C · Checking leg pulses, colour, warmth and sensation
2.Med-surg: cardiovascular & respiratory
Answer: D · Acute respiratory distress syndrome
Why this is the answer
ARDS is acute, non-cardiogenic pulmonary oedema caused by widespread inflammation, triggered by sepsis, pneumonia, trauma or pancreatitis. It causes severe hypoxaemia that responds poorly to oxygen, with bilateral infiltrates not explained by heart failure. Treatment includes lung-protective ventilation and often prone positioning.
Answer
D · Acute respiratory distress syndrome
3.Med-surg: neuro, endocrine & renal
Answer: A · Drink plenty of fluid so the urine stays pale
Why this is the answer
High fluid intake is the most important measure for preventing stones. Dietary calcium is usually not restricted, because it binds oxalate in the gut. High-dose vitamin C can increase oxalate.
Answer
A · Drink plenty of fluid so the urine stays pale
4.Med-surg: neuro, endocrine & renal
Answer: D · Phaeochromocytoma
Why this is the answer
Phaeochromocytoma is a catecholamine-secreting tumour, usually of the adrenal medulla. It causes episodic hypertension, headache, sweating and tachycardia. Before surgery, alpha-blockade is started before any beta-blocker, because beta-blockade alone can cause a hypertensive crisis.
Answer
D · Phaeochromocytoma
5.Med-surg: GI, perioperative & oncology
Answer: A · On the right side, to press on the puncture site
Why this is the answer
Lying on the right side presses the liver capsule against the chest wall and helps stop bleeding. The nurse monitors pulse and BP closely for haemorrhage, which is the main risk.
Answer
A · On the right side, to press on the puncture site
6.Med-surg: GI, perioperative & oncology
Answer: C · Hypoglycaemia if insulin continues without the feed
Why this is the answer
When feed stops but insulin continues, blood glucose can fall sharply. The insulin plan is reviewed with the team, glucose is checked frequently, and a glucose infusion may be needed.
Answer
C · Hypoglycaemia if insulin continues without the feed
7.Clinical nursing
Answer: A · Avoid large meals late in the evening and raise the head of the bed
Why this is the answer
Smaller meals, not eating close to bedtime, raising the head of the bed, weight loss and stopping smoking reduce reflux. Lying flat after eating makes it worse.
Answer
A · Avoid large meals late in the evening and raise the head of the bed
8.Clinical nursing
Answer: B · Infusion-related reaction; stop or slow the infusion and inform the prescriber
Why this is the answer
Rapid vancomycin infusion can release histamine and cause flushing and rash ("vancomycin infusion reaction"). Slowing the rate usually prevents it, but anaphylaxis must be excluded.
Answer
B · Infusion-related reaction; stop or slow the infusion and inform the prescriber
9.Lab values & electrolytes
Answer: C · A normal rise from placental ALP
Why this is the answer
The placenta produces ALP, so serum ALP normally rises in late pregnancy. With normal bilirubin, ALT and AST, this is expected. Symptoms such as severe itching or raised bile acids would need further review.Checked against:Alkaline Phosphatase · MedlinePlus (NIH) (2024)
Answer
C · A normal rise from placental ALP
10.Lab values & electrolytes
Answer: A · "I'll take my iron tablet with a big glass of milk"
Why this is the answer
Calcium in milk, as well as antacids and tea, reduces iron absorption, so iron should not be taken with them. Vitamin C improves absorption, dark stools are expected, and iron overdose is a serious poisoning risk in young children.Checked against:Iron deficiency anemia - Medical Encyclopedia · MedlinePlus (NIH) (2025); Iron in diet - Medical Encyclopedia · MedlinePlus (NIH) (2025)
Answer
A · "I'll take my iron tablet with a big glass of milk"
11.Arterial blood gas interpretation
Answer: PaCO₂ = 32 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·16 + 8 = 32 mmHg
range: 30–34 mmHg
Answer
PaCO₂ = 32 mmHg
12.Arterial blood gas interpretation
Answer: A–a gradient = 91.9 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Alveolar oxygen
PAO₂ = 0.3·713 − 44/0.8 = 213.9 − 55 = 158.9 mmHg
Gradient
A–a = 158.9 − 67 = 91.9 mmHg
Answer
A–a gradient = 91.9 mmHg
13.ECG rhythm strip interpretation
Answer: pause = 2 s
Narrow-complex tachycardia and pauses: supraventricular tachycardia (SVT) is a regular tachycardia at about 150–250/min with narrow QRS complexes; the P waves are usually not visible because they are hidden in the QRS complex or the T wave. Sinus tachycardia in an adult at rest is usually below about 150/min and has a visible P wave before every QRS; atrial flutter with 2:1 conduction often runs at about 150/min and shows sawtooth waves. In sinus arrest the sinus node stops firing for a moment: a pause with no P wave and no QRS whose length is not a whole number of P–P cycles (a pause of exactly two or three cycles points to sinus exit block instead).
Measure
50 small boxes from R to R across the pause
Convert
pause = 50 × 0.04 s = 2 s
Compare with P–P
2.00 ÷ 0.88 ≈ 2.3 P–P cycles, not a whole number
Answer
pause = 2 s
No P wave appears in the pause, and the pause is not a whole number of P–P cycles: sinus arrest. A pause of exactly two or three cycles would point to sinus exit block.
14.ECG rhythm strip interpretation
Answer: ventricular tachycardia
Ventricular rhythms: ventricular tachycardia is a run of three or more wide (0.12 s or more) complexes in a row at more than 100/min, usually 150–250/min, regular, without related P waves. Ventricular fibrillation is a chaotic, irregular waveform with no identifiable P waves, QRS complexes or T waves and no countable rate. Asystole is an almost flat line with no ventricular activity; a flat line is always confirmed by checking the patient, the leads and the gain and a second lead. In resuscitation guidelines VF and pulseless VT are the shockable rhythms and asystole is not.
Five steps
1. Rate: R–R = 10 small boxes, 1500 ÷ 10 ≈ 150 per minute.
2. Rhythm: regular, every R–R is 0.40 s.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: 0.16 s, wide (0.12 s or more).
Interpretation
ventricular tachycardia
Answer
ventricular tachycardia
In resuscitation guidelines VF and pulseless VT are the shockable rhythms. This is identification practice only.
15.Prioritization & delegation
Answer: D · Day 1 after bowel surgery, new chest pain and heart rate 110/min
Why this is the answer
New chest pain and tachycardia after surgery could be a myocardial infarction or pulmonary embolism. This patient needs immediate assessment; the others have routine needs.
Answer
D · Day 1 after bowel surgery, new chest pain and heart rate 110/min
16.Prioritization & delegation
Answer: A · Metabolic alkalosis
Why this is the answer
Repeated vomiting of stomach contents loses hydrochloric acid, causing metabolic alkalosis, often with low chloride and potassium. Fluids and electrolytes are corrected before surgery.