Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient is on a short course of oral prednisolone for an asthma exacerbation. Which effect should the nurse monitor for?
ARaised blood glucose
BLow blood pressure
CLow blood sodium
DSlow heart rate
2.Med-surg: cardiovascular & respiratoryHard
A nurse finds a patient collapsed in bed and unresponsive. What should the nurse do first?
AGive two rescue breaths, then check the blood glucose before calling anyone
BShout for help, open the airway and check breathing for up to 10 seconds
CLeave the patient to fetch a defibrillator before calling anyone
DTake a full set of observations, including temperature and blood glucose
3.Med-surg: neuro, endocrine & renalMedium
A patient has radioactive iodine treatment for hyperthyroidism. Which advice is correct?
AStay in strict isolation in hospital for several months
BStart breastfeeding again the next day
CLimit close contact with children and pregnant women for a time
DThere are no precautions, because the dose is tiny
4.Med-surg: neuro, endocrine & renalHard
A patient with hypothyroidism who has missed medication for weeks is admitted hypothermic and drowsy, with a pulse of 46/min, low sodium and a raised PaCO₂. Which condition is most likely?
AMyxoedema coma
BHeat stroke
CAdrenal crisis
DThyroid storm
5.Med-surg: GI, perioperative & oncologyMedium
Why is regular (scheduled) analgesia often preferred to "as required" doses in the first days after major surgery?
AIt allows doses higher than the maximum daily limit to be given
BIt completely prevents all opioid side effects
CIt keeps drug levels steady and prevents severe peaks of pain
DIt removes the need to assess the patient's pain during the day
6.Med-surg: GI, perioperative & oncologyHard
A patient with a sacral pressure ulcer keeps sliding down the bed when the head is raised high. Which advice best reduces shear?
ASit the patient upright without any support for the feet
BRaise the head of the bed to 90° and pull the patient up the bed by the arms
CKeep the head of the bed at or below 30° if possible; use slide sheets
DUse a dry sheet and drag the patient up the bed
7.Clinical nursingMedium
Which advice is correct for a patient taking levothyroxine?
ATake it with a large meal to avoid nausea and stomach upset
BTake it only on days when feeling tired
CTake it on an empty stomach, usually before breakfast
DStop taking it once the symptoms improve
8.Clinical nursingHard
Why is morphine more likely to cause toxicity in a patient with severe kidney impairment?
AKidney failure makes the stomach absorb more morphine
BKidney disease makes the opioid receptors disappear
CThe kidneys normally activate morphine, so more of it becomes active
DIts active metabolites build up because the kidneys excrete them
9.Lab values & electrolytesMedium
A patient has weight loss, tremor and heat intolerance. Which thyroid test pattern fits Graves disease?
AHigh TSH with a normal free T4
BLow TSH with a high free T4
CNormal TSH with a low free T4
DHigh TSH with a low free T4
10.Lab values & electrolytesHard
A patient on a heparin infusion has a platelet count that falls from 260 to 110 × 10³/µL on day 7. Which action is most appropriate?
AReport it at once: heparin-induced thrombocytopenia is possible
BContinue the infusion and increase the rate as per protocol
CGive a platelet transfusion and continue the heparin
DTake no action, because the count is still just above 100 × 10³/µL
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 152 mmol/L, glucose 9.5 mmol/L and urea 12.3 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 152 mmol/Lglucose 9.5 mmol/Lurea 12.3 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
A practice gas shows pH 7.32, PaCO₂ 34 mmHg (4.5 kPa) and HCO₃⁻ 17 mmol/L, with Na⁺ 145 and Cl⁻ 94 mmol/L. Use the anion gap and the delta ratio to click the best interpretation.
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1atrial flutter, 2:1 conduction
2atrial fibrillation
3normal sinus rhythm
4sinus tachycardia
14.ECG rhythm strip interpretationHard
This lead II strip shows second-degree AV block type I (Wenckebach). By how much does the PR interval increase from the first to the second beat of a group (ΔPR), in seconds?
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
ΔPR = s
15.Prioritization & delegationMedium
Which task should the nurse delegate to a nursing assistant for a patient on fall precautions?
ADeciding whether the bed alarm is still needed
BHelping the patient to the toilet every 2 hours as planned
CTeaching the family how to prevent falls at home
DAssessing and recording the patient’s fall risk score each morning
16.Prioritization & delegationHard
A patient with untreated hyperthyroidism has surgery and develops a temperature of 40 °C, a heart rate of 160/min and severe agitation. What is most likely happening?
AMyxedema coma
BA normal reaction to pain
COpioid withdrawal
DThyroid storm
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · Raised blood glucose
Why this is the answer
Corticosteroids raise blood glucose, which matters especially in diabetes. Short courses can also cause mood changes, insomnia, indigestion and fluid retention. Long-term use adds osteoporosis, adrenal suppression and infection risk.
Answer
A · Raised blood glucose
2.Med-surg: cardiovascular & respiratory
Answer: B · Shout for help, open the airway and check breathing for up to 10 seconds
Why this is the answer
In hospital, the nurse shouts for help, opens the airway and looks for normal breathing (and a pulse if trained) for up to 10 seconds. If the patient is not breathing normally, the arrest team is called and CPR started, with a defibrillator brought as soon as possible.
Answer
B · Shout for help, open the airway and check breathing for up to 10 seconds
3.Med-surg: neuro, endocrine & renal
Answer: C · Limit close contact with children and pregnant women for a time
Why this is the answer
After radioiodine, patients are advised to limit close and prolonged contact, especially with young children and pregnant women, for a period set by the department. It is contraindicated in pregnancy and breastfeeding.
Answer
C · Limit close contact with children and pregnant women for a time
4.Med-surg: neuro, endocrine & renal
Answer: A · Myxoedema coma
Why this is the answer
Myxoedema coma presents with reduced consciousness, hypothermia, bradycardia, hypoventilation, hyponatraemia and hypoglycaemia, often triggered by infection or missed treatment. It needs critical care, IV thyroid hormone, steroid cover until adrenal insufficiency is excluded, passive rewarming and great care with sedatives.
Answer
A · Myxoedema coma
5.Med-surg: GI, perioperative & oncology
Answer: C · It keeps drug levels steady and prevents severe peaks of pain
Why this is the answer
Predictable, continuous postoperative pain is best managed with regular multimodal analgesia (for example paracetamol and, where safe, an NSAID), with as-needed doses for breakthrough pain. Pain and side effects are still assessed regularly.
Answer
C · It keeps drug levels steady and prevents severe peaks of pain
6.Med-surg: GI, perioperative & oncology
Answer: C · Keep the head of the bed at or below 30° if possible; use slide sheets
Why this is the answer
A high head position makes patients slide, causing shear on the sacrum. A lower head position when clinically possible, knee break or foot support, and slide sheets for moving reduce shear and friction.
Answer
C · Keep the head of the bed at or below 30° if possible; use slide sheets
7.Clinical nursing
Answer: C · Take it on an empty stomach, usually before breakfast
Why this is the answer
Levothyroxine is absorbed best on an empty stomach and is usually taken at the same time each morning. It is normally lifelong, with doses adjusted by thyroid blood tests.
Answer
C · Take it on an empty stomach, usually before breakfast
8.Clinical nursing
Answer: D · Its active metabolites build up because the kidneys excrete them
Why this is the answer
Morphine metabolites, including morphine-6-glucuronide, are cleared by the kidneys and accumulate in renal impairment, causing sedation and respiratory depression. Alternative opioids or lower doses are often chosen.
Answer
D · Its active metabolites build up because the kidneys excrete them
9.Lab values & electrolytes
Answer: B · Low TSH with a high free T4
Why this is the answer
In Graves disease, antibodies stimulate the thyroid to make too much hormone. The high free T4 suppresses TSH from the pituitary through negative feedback, so TSH is low. A high TSH with a low T4 fits primary hypothyroidism.Checked against:TSH test · MedlinePlus (NIH) (2026); Thyroxine (T4) Test · MedlinePlus (NIH) (2024); Graves disease · MedlinePlus (NIH) (2026)
Answer
B · Low TSH with a high free T4
10.Lab values & electrolytes
Answer: A · Report it at once: heparin-induced thrombocytopenia is possible
Why this is the answer
Heparin-induced thrombocytopenia causes a large fall in platelets (often more than half), usually 5–14 days after starting heparin, and carries a high risk of clots. The prescriber stops all heparin and starts a non-heparin anticoagulant if HIT is suspected.Checked against:Heparin-Induced Thrombocytopenia · StatPearls (NCBI Bookshelf) (2023)
Answer
A · Report it at once: heparin-induced thrombocytopenia is possible
11.Arterial blood gas interpretation
Answer: Osm = 326 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·152 + 9.5 + 12.3 = 325.8 ≈ 326 mOsm/kg
Answer
Osm = 326 mOsm/kg
12.Arterial blood gas interpretation
Answer: added metabolic alkalosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 145 − (94 + 17) = 34
Delta ratio
(34 − 12)/(24 − 17) = 3.143
added metabolic alkalosis
Answer
added metabolic alkalosis
13.ECG rhythm strip interpretation
Answer: sinus tachycardia
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 12 small boxes, 1500 ÷ 12 ≈ 125 per minute.
2. Rhythm: regular, every R–R is 0.48 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.14 s, constant, within 0.12–0.20 s.
5. QRS: 0.10 s, narrow (below 0.12 s).
Interpretation
sinus tachycardia
Answer
sinus tachycardia
14.ECG rhythm strip interpretation
Answer: ΔPR = 0.14 s
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
March out the P waves
P–P = 0.96 s, regular; one P wave in every 3 is not conducted
PR in each group
PR₁ = 0.16 s, PR₂ = 0.30 s
Answer
ΔPR = 0.14 s
The biggest step in PR comes between the first and second beats of a group; later steps are smaller, which is why the R–R intervals shorten before the pause.
15.Prioritization & delegation
Answer: B · Helping the patient to the toilet every 2 hours as planned
Why this is the answer
A scheduled toileting round is a routine task that follows the care plan. Scoring fall risk, deciding on interventions and teaching need nursing judgement.
Answer
B · Helping the patient to the toilet every 2 hours as planned
16.Prioritization & delegation
Answer: D · Thyroid storm
Why this is the answer
Thyroid storm is a life-threatening surge of thyroid hormone, with fever, tachycardia and agitation or confusion. It needs urgent treatment; myxedema coma is the opposite extreme of hypothyroidism.