Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which side effect is particularly common with verapamil?
ADry cough
BDiarrhoea
CHair loss
DConstipation
2.Med-surg: cardiovascular & respiratoryHard
A patient with an acute COPD exacerbation who retains CO₂ is prescribed nebulised bronchodilators. How should the nebuliser usually be driven?
AWith oxygen at 15 L/min for as long as possible
BWith oxygen at 6–8 L/min and no saturation monitoring
CWith compressed air, plus controlled oxygen by nasal cannula
DWith no gas flow, by asking the patient to breathe deeply
3.Med-surg: neuro, endocrine & renalMedium
Which approach helps most when talking to a patient with expressive aphasia?
AAvoid talking to them until their speech has recovered
BAsk questions that can be answered with yes, no or a gesture
CSpeak louder, because the patient cannot hear well
DFinish their sentences quickly to save them effort
4.Med-surg: neuro, endocrine & renalHard
A patient with Parkinson's disease is nil by mouth after abdominal surgery. Their levodopa is due. What is the best action?
AContact the prescriber or pharmacist about another route
BOmit the dose until the patient can swallow again
CGive the tablets with a sip of water anyway
DGive double the dose once eating restarts
5.Med-surg: GI, perioperative & oncologyMedium
How should pancreatic enzyme replacement capsules usually be taken?
AOne hour after meals, on an empty stomach
BWith every meal and snack
COnce a day at bedtime
DOnly on days with abdominal pain
6.Med-surg: GI, perioperative & oncologyHard
A patient is splashed in the eye with an alkaline cleaning product. What is the first action?
ACover the eye with a pad and wait for a doctor to examine it first
BAdd a few drops of vinegar to neutralise it
CIrrigate the eye at once with large volumes of water or saline
DAsk the patient to rub the eye to clear it
7.Clinical nursingMedium
Which side effects are common after high doses of salbutamol (albuterol)?
ATremor and a fast heart rate
BHair loss and weight gain
CConstipation and urinary retention
DBradycardia and drowsiness
8.Clinical nursingHard
A nurse teaches a patient with a new ileostomy. Which statement shows a need for further teaching?
A"I will empty the bag when it is about a third to half full."
B"My output will be firm and formed like before."
C"I will drink extra fluids when it is hot."
D"My stoma should look pink or red and moist."
9.Lab values & electrolytesMedium
A patient with sickle cell disease takes hydroxyurea. Which laboratory test is monitored regularly for an adverse effect?
ASerum amylase level
BComplete blood count
CUrine ketone level
DSerum lithium level
10.Lab values & electrolytesHard
A patient receiving IV magnesium sulfate has a respiratory rate of 9/min and absent patellar reflexes. After stopping the infusion, which medication should the nurse expect to give?
ASodium bicarbonate
BPotassium chloride
CCalcium gluconate
DProtamine sulfate
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 146 mmol/L, glucose 9.3 mmol/L and urea 4.6 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 146 mmol/Lglucose 9.3 mmol/Lurea 4.6 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 35 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 35 mmol/L
PaCO₂ = mmHg
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Interpret this lead II strip with the five steps in order: rate, rhythm, P waves, PR interval, QRS duration. At which step do you find the first abnormal finding? Click it.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1rate
2rhythm
3P waves
4PR interval
5QRS duration
15.Prioritization & delegationMedium
Which patient is most appropriate to assign to an LPN/LVN?
AA patient about to receive a first unit of red blood cells
BA patient with stable chronic heart failure who needs oral medications
CA patient admitted 30 minutes ago with new chest pain
DA patient arriving from the recovery room who needs an initial assessment
16.Prioritization & delegationHard
A patient with suspected sepsis has four prescribed orders. Which should usually be done first?
AArrange a chest X-ray for later today
BRepeat the lactate in six hours
CTake blood cultures
DGive the IV antibiotic
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · Constipation
Why this is the answer
Verapamil is a rate-limiting calcium channel blocker that slows AV conduction. Constipation is its most common side effect. It can also cause bradycardia and should not be combined with beta-blockers without specialist care because of the risk of heart block.
Answer
D · Constipation
2.Med-surg: cardiovascular & respiratory
Answer: C · With compressed air, plus controlled oxygen by nasal cannula
Why this is the answer
Nebulisers need about 6–8 L/min. Driving them with oxygen in a patient with hypercapnic respiratory failure can push saturation too high and worsen CO₂ retention. Air-driven nebulisers, with separate controlled oxygen titrated to 88–92%, are recommended.
Answer
C · With compressed air, plus controlled oxygen by nasal cannula
3.Med-surg: neuro, endocrine & renal
Answer: B · Ask questions that can be answered with yes, no or a gesture
Why this is the answer
In expressive aphasia, comprehension is largely preserved. Short, closed questions, extra time, gestures and picture or word boards help. Shouting does not help, and constantly finishing sentences can frustrate the patient.
Answer
B · Ask questions that can be answered with yes, no or a gesture
4.Med-surg: neuro, endocrine & renal
Answer: A · Contact the prescriber or pharmacist about another route
Why this is the answer
Omitting Parkinson's medication can cause severe rigidity, swallowing failure and, rarely, a life-threatening withdrawal syndrome. Alternatives such as giving it by nasogastric tube or a dopamine agonist patch should be arranged urgently.
Answer
A · Contact the prescriber or pharmacist about another route
5.Med-surg: GI, perioperative & oncology
Answer: B · With every meal and snack
Why this is the answer
Pancreatic enzymes digest fat, protein and carbohydrate, so they are taken with meals and snacks. The dose is adjusted to reduce steatorrhoea and support weight gain.
Answer
B · With every meal and snack
6.Med-surg: GI, perioperative & oncology
Answer: C · Irrigate the eye at once with large volumes of water or saline
Why this is the answer
Alkali burns can cause severe, deep eye damage. Immediate, prolonged irrigation, checking the pH, and urgent ophthalmology review are needed. Neutralising agents are not used.
Answer
C · Irrigate the eye at once with large volumes of water or saline
7.Clinical nursing
Answer: A · Tremor and a fast heart rate
Why this is the answer
Salbutamol is a beta2-agonist and can cause tremor, tachycardia and palpitations. High doses can also lower serum potassium.
Answer
A · Tremor and a fast heart rate
8.Clinical nursing
Answer: B · "My output will be firm and formed like before."
Why this is the answer
Ileostomy output is liquid to porridge-like because it bypasses the colon. The other statements describe correct care: good hydration, emptying the bag before it is too heavy and recognising a healthy stoma.
Answer
B · "My output will be firm and formed like before."
9.Lab values & electrolytes
Answer: B · Complete blood count
Why this is the answer
Hydroxyurea increases fetal hemoglobin and reduces sickling crises, but it can suppress the bone marrow. The CBC, including neutrophils and platelets, is monitored regularly, and doses are adjusted if counts fall.Checked against:Sickle cell disease · MedlinePlus (NIH) (2026)
Answer
B · Complete blood count
10.Lab values & electrolytes
Answer: C · Calcium gluconate
Why this is the answer
Absent reflexes and slow breathing indicate magnesium toxicity. The infusion is stopped, the provider is called, the airway and breathing are supported, and IV calcium gluconate is given as prescribed to counteract magnesium.
Answer
C · Calcium gluconate
11.Arterial blood gas interpretation
Answer: Osm = 306 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·146 + 9.3 + 4.6 = 305.9 ≈ 306 mOsm/kg
Answer
Osm = 306 mOsm/kg
12.Arterial blood gas interpretation
Answer: PaCO₂ = 45.5 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·35 + 21 = 45.5 mmHg
Answer
PaCO₂ = 45.5 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
13.ECG rhythm strip interpretation
Answer: QTc = 0.451 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9.5 × 0.04 = 0.38 s
RR = 15 × 0.04 = 0.60 s
Fridericia’s formula
QTc = 0.38/∛0.60 = 0.38/0.8434 = 0.451 s
Answer
QTc = 0.451 s
Between the usual limits for men (about 0.45 s) and women (about 0.46 s): borderline, depending on the reference used. (451 ms)
14.ECG rhythm strip interpretation
Answer: QRS duration
Five steps for every strip: 1. rate (300 or 1500 method, or the 6-second method if irregular); 2. rhythm: are the R–R intervals equal; 3. P waves: present, upright in lead II, one before every QRS and all alike; 4. PR interval: 0.12–0.20 s and constant; 5. QRS duration: below 0.12 s. Only after the five steps name the rhythm. Normal sinus rhythm passes all five: 60–100/min, regular, upright P before every QRS, PR 0.12–0.20 s, QRS below 0.12 s.
Five steps
1. Rate: R–R = 18 small boxes, 1500 ÷ 18 ≈ 83 per minute.
2. Rhythm: regular, every R–R is 0.72 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.14 s, constant, within 0.12–0.20 s.
5. QRS: 0.16 s, wide (0.12 s or more).
First abnormal step
QRS duration → sinus rhythm with wide QRS
Answer
QRS duration
15.Prioritization & delegation
Answer: B · A patient with stable chronic heart failure who needs oral medications
Why this is the answer
Stable chronic heart failure with routine oral medicines is predictable care. New chest pain, the start of a transfusion and the first assessment after surgery need RN assessment.
Answer
B · A patient with stable chronic heart failure who needs oral medications
16.Prioritization & delegation
Answer: C · Take blood cultures
Why this is the answer
Blood cultures are taken before the first antibiotic dose when this does not cause significant delay, so the organism can be identified. The antibiotic follows as soon as possible.