Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with heart failure is comfortable at rest but becomes breathless walking across a room. Which NYHA class fits best?
AClass III
BClass I
CClass II
DClass IV
2.Med-surg: cardiovascular & respiratoryHard
A patient with crushing chest pain has ST elevation in leads V1–V4. Which coronary artery is most likely blocked?
AThe left subclavian artery
BThe right coronary artery and its branches
CThe left anterior descending artery
DThe circumflex artery
3.Med-surg: neuro, endocrine & renalMedium
In a patient with an acute spinal cord injury at C6, which picture suggests neurogenic shock?
ALow blood pressure, fast pulse and cold, clammy skin
BHigh blood pressure, slow pulse and a pounding headache
CNormal blood pressure, fast pulse and a high fever
DLow blood pressure, slow pulse and warm, dry skin
4.Med-surg: neuro, endocrine & renalHard
A woman with epilepsy who takes valproate says she is planning a pregnancy. Which response is most appropriate?
ASuggest doubling the dose to protect the baby from seizures
BTell her to stop taking the valproate completely from today
CAdvise not stopping it suddenly and urgent specialist review
DReassure her that valproate is safe throughout pregnancy
5.Med-surg: GI, perioperative & oncologyMedium
How should a patient with facial burns usually be positioned?
ALying face down on the pillow to protect the airway
BWith the head of the bed raised to reduce swelling
CLying flat with the head lower than the feet
DIn any position that keeps the face covered
6.Med-surg: GI, perioperative & oncologyHard
A patient with known prostate cancer reports new, worsening back pain and leg weakness. What is the most important action?
AArrange routine physiotherapy for the back pain in the next month
BReassure the patient that back pain is common and not serious
CAdvise rest at home with paracetamol and review at the next clinic visit
DPossible cord compression: escalate, steroids as prescribed, urgent MRI
7.Clinical nursingMedium
A dying patient can no longer drink and has a dry mouth. What is the most appropriate nursing care?
AFrequent mouth care that keeps the lips and mouth moist
BInserting a nasogastric tube for fluids
CStarting a fast intravenous infusion to correct the dryness
DLeaving the mouth alone to avoid disturbing them
8.Clinical nursingHard
After a head injury, a patient has clear fluid leaking from the nose. What does this most likely suggest?
AAcute sinusitis
BA normal and harmless response to head trauma
CA base-of-skull fracture with a cerebrospinal fluid leak
DAllergic rhinitis triggered by the hospital environment
9.Lab values & electrolytesMedium
A patient with central diabetes insipidus starts desmopressin. Which laboratory result is most important to monitor for an adverse effect?
ASerum glucose, which may rise very high
BSerum calcium, which may rise too high
CSerum potassium, which may rise too high
DSerum sodium, which may fall too low
10.Lab values & electrolytesHard
Three days after starting haloperidol, a patient has a temperature of 40 °C, severe muscle rigidity and confusion. Which laboratory result would the nurse expect?
AA very high creatine kinase (CK)
BA very low white cell count
CA very high serum lithium
DA very low serum sodium
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.25, PaCO₂ 57 mmHg (7.6 kPa) and HCO₃⁻ 24 mmol/L. The primary disorder is respiratory acidosis. How far is it compensated? Click your answer.
pH 7.25PaCO₂ 57 mmHg (7.6 kPa)HCO₃⁻ 24 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 21% oxygen shows PaO₂ 69 mmHg (9.2 kPa) and PaCO₂ 60 mmHg (8.0 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1atrial fibrillation
2third-degree (complete) AV block
3first-degree AV block
4second-degree AV block type I (Wenckebach)
15.Prioritization & delegationMedium
A patient receiving chemotherapy has a temperature of 38.3 °C and a very low neutrophil count. What should the nurse do?
AGive a cool shower and offer extra fluids, then wait and see what happens
BReport it at once, because cultures and antibiotics are needed quickly
CDocument the reading and mention it at the next handover
DRecheck the temperature in four hours before telling anyone
16.Prioritization & delegationHard
Which patient with cirrhosis should the nurse see first?
ALong-standing jaundice and itchy skin, asking for cream
BWants to talk about stopping drinking alcohol for good
CVomiting bright red blood, heart rate 120/min
DLarge ascites that is unchanged from yesterday
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · Class III
Why this is the answer
NYHA class I has no limitation, class II slight limitation with ordinary activity, class III marked limitation with less than ordinary activity but comfortable at rest, and class IV symptoms at rest. The class guides treatment and prognosis.
Answer
A · Class III
2.Med-surg: cardiovascular & respiratory
Answer: C · The left anterior descending artery
Why this is the answer
ST elevation in V1–V4 indicates an anteroseptal STEMI, usually from LAD occlusion. Anterior MIs damage a large area of muscle and carry a high risk of heart failure and arrhythmias. Leads II, III and aVF suggest an inferior MI, usually from the right coronary artery.
Answer
C · The left anterior descending artery
3.Med-surg: neuro, endocrine & renal
Answer: D · Low blood pressure, slow pulse and warm, dry skin
Why this is the answer
Neurogenic shock follows injury at T6 or above. Loss of sympathetic tone causes vasodilation (warm, dry skin) and unopposed vagal activity (bradycardia). Hypovolaemic shock causes tachycardia and cold, clammy skin; a trauma patient may have both, so bleeding must still be looked for.
Answer
D · Low blood pressure, slow pulse and warm, dry skin
4.Med-surg: neuro, endocrine & renal
Answer: C · Advise not stopping it suddenly and urgent specialist review
Why this is the answer
Valproate is highly teratogenic (neural tube defects and neurodevelopmental problems), and its use in people who could become pregnant is tightly restricted. However, stopping antiseizure medication suddenly risks status epilepticus. Urgent specialist review to plan a safer alternative, plus folic acid supplementation, is needed.
Answer
C · Advise not stopping it suddenly and urgent specialist review
5.Med-surg: GI, perioperative & oncology
Answer: B · With the head of the bed raised to reduce swelling
Why this is the answer
Raising the head reduces facial and airway swelling. The airway is monitored closely because swelling can increase over the first 24–48 hours.
Answer
B · With the head of the bed raised to reduce swelling
6.Med-surg: GI, perioperative & oncology
Answer: D · Possible cord compression: escalate, steroids as prescribed, urgent MRI
Why this is the answer
Back pain with neurological symptoms in a patient with cancer suggests metastatic spinal cord compression. Early diagnosis (urgent whole-spine MRI) and treatment (dexamethasone, radiotherapy or surgery) preserve mobility and continence. Late presentation often leads to permanent paralysis.
Answer
D · Possible cord compression: escalate, steroids as prescribed, urgent MRI
7.Clinical nursing
Answer: A · Frequent mouth care that keeps the lips and mouth moist
Why this is the answer
Regular mouth care with moist swabs, water sprays and lip balm relieves a dry mouth in the last days of life. Families can be shown how to help.
Answer
A · Frequent mouth care that keeps the lips and mouth moist
8.Clinical nursing
Answer: C · A base-of-skull fracture with a cerebrospinal fluid leak
Why this is the answer
Clear fluid from the nose or ear after head injury suggests a CSF leak from a skull base fracture, with a risk of meningitis. Nasal tubes and nose-blowing should be avoided and the patient reviewed urgently.
Answer
C · A base-of-skull fracture with a cerebrospinal fluid leak
9.Lab values & electrolytes
Answer: D · Serum sodium, which may fall too low
Why this is the answer
Desmopressin acts like ADH, so the kidneys retain water. If the patient drinks too much, water retention can cause hyponatremia, which may lead to confusion and seizures. Sodium, weight and fluid balance are monitored.
Answer
D · Serum sodium, which may fall too low
10.Lab values & electrolytes
Answer: A · A very high creatine kinase (CK)
Why this is the answer
These signs suggest neuroleptic malignant syndrome, a medical emergency. Muscle rigidity releases CK, often to very high levels, and the white count is often raised. Myoglobin can damage the kidneys. The antipsychotic is stopped and supportive care is started.
Answer
A · A very high creatine kinase (CK)
11.Arterial blood gas interpretation
Answer: uncompensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.25: acidaemia (below 7.35)
PaCO₂ 57 mmHg: high (35–45)
HCO₃⁻ 24 mmol/L: normal (22–26)
Compensation
uncompensated
Answer
uncompensated
12.Arterial blood gas interpretation
Answer: A–a gradient = 5.73 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 10.5 × 0.04 = 0.42 s
RR = 17 × 0.04 = 0.68 s
Bazett’s formula
QTc = 0.42/√0.68 = 0.42/0.8246 = 0.509 s
Answer
QTc = 0.509 s
Above 0.50 s: markedly prolonged. (509 ms)
14.ECG rhythm strip interpretation
Answer: second-degree AV block type I (Wenckebach)
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: 4 QRS complexes in 6 s, × 10 = 40 per minute.
2. Rhythm: regularly irregular, the QRS complexes come in groups separated by a pause (group beating).
3. P waves: upright and regular (P–P 0.88 s, 68 per minute); one P in every 3 is not followed by a QRS.
4. PR interval: lengthens 0.16 → 0.30 s, then a P wave is not conducted.
5. QRS: 0.08 s, narrow (below 0.12 s).
Interpretation
second-degree AV block type I (Wenckebach)
Answer
second-degree AV block type I (Wenckebach)
15.Prioritization & delegation
Answer: B · Report it at once, because cultures and antibiotics are needed quickly
Why this is the answer
Neutropenic fever is a medical emergency. The patient may have few other signs of infection, so the nurse reports it immediately so that cultures can be taken and IV antibiotics started.
Answer
B · Report it at once, because cultures and antibiotics are needed quickly
16.Prioritization & delegation
Answer: C · Vomiting bright red blood, heart rate 120/min
Why this is the answer
Vomiting blood with a fast pulse suggests bleeding esophageal varices, which can quickly be fatal. The other findings are chronic or stable.