Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which vaccinations are usually recommended for people with COPD?
AA yearly tetanus booster only
BAnnual influenza and pneumococcal vaccination
CA BCG vaccine every five years
DNo vaccines at all, as they are known to trigger exacerbations
2.Med-surg: cardiovascular & respiratoryHard
The monitor shows a regular broad-complex tachycardia at 180/min. The patient is alert with BP 126/78 mmHg and no chest pain. What is the most appropriate plan?
AStart chest compressions straight away and give a dose of IV adrenaline
BDeliver an unsynchronised shock immediately, before any other assessment
CReassure the patient, as this is a normal rhythm
DRecord a 12-lead ECG, call senior help and anticipate an antiarrhythmic
3.Med-surg: neuro, endocrine & renalMedium
A stroke patient with dysphagia has been started on a modified diet. Which action best reduces the risk of aspiration?
AFeed quickly so the patient does not tire during the meal
BLay the patient flat straight after meals so they can rest and digest
CGive fluids through a straw so they flow more slowly
DSit the patient fully upright for meals and for a while afterwards
4.Med-surg: neuro, endocrine & renalHard
A large pituitary tumour presses on the optic chiasm. Which visual field defect is most typical?
ALoss of the outer half of the field in both eyes
BLoss of central vision in both eyes
CComplete blindness in one eye only
DLoss of the inner half of the field in both eyes
5.Med-surg: GI, perioperative & oncologyMedium
Which infection control measure is correct for a patient with C. difficile diarrhoea?
AA shared bay, as long as alcohol gel is used after every contact
BA face mask for the patient and visitors only
CNo special measures once antibiotics have started
DA single room with its own toilet, and soap-and-water handwashing
6.Med-surg: GI, perioperative & oncologyHard
A patient has a category (stage) 2 pressure ulcer on the sacrum. Which plan is most appropriate?
ALeave it uncovered and dry it with a hair dryer
BMassage around the wound every hour to stimulate blood flow to the skin
CSit the patient upright in a chair for most of the day
DOffload the area, manage moisture, support nutrition and dress it
7.Clinical nursingMedium
A patient with MRSA colonisation is admitted. Which precautions are appropriate?
AAirborne precautions with an FFP3 respirator mask for all staff
BIsolation in a negative-pressure room for six months
CNo precautions are needed for colonisation
DContact precautions with gloves, apron and good hand hygiene
8.Clinical nursingHard
After a high spinal cord injury, a patient has low blood pressure with a slow heart rate and warm, dry skin. What is most likely?
AHypovolaemic shock
BCardiac tamponade
CNeurogenic shock
DSeptic shock
9.Lab values & electrolytesMedium
A patient with schizophrenia is starting clozapine. Which laboratory value must be monitored regularly?
AInternational normalized ratio
BSerum amylase
CSerum lithium level
DAbsolute neutrophil count
10.Lab values & electrolytesHard
An older adult with type 2 diabetes is drowsy and very dehydrated. Glucose 920 mg/dL (51 mmol/L), serum osmolality 350 mOsm/kg, pH 7.36, urine ketones negative or trace. Which condition fits best?
ADiabetic ketoacidosis (DKA)
BMetformin-related lactic acidosis
CHyperosmolar hyperglycemic state (HHS)
DSyndrome of inappropriate ADH (SIADH)
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 16 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 16 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.07, PaCO₂ 32 mmHg (4.3 kPa), HCO₃⁻ 9 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.07PaCO₂ 32 mmHg (4.3 kPa)HCO₃⁻ 9 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This patient has a pacemaker. Interpret the lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1dual-chamber (AV) paced rhythm
2ventricular paced rhythm
3sinus rhythm with wide QRS
4third-degree (complete) AV block
15.Prioritization & delegationMedium
Which newborn finding needs prompt reporting?
ABluish hands and feet in the first hours
BMilia (small white spots) on the nose
CMild jaundice that first appears on the third day
DJaundice that appears within the first 24 hours
16.Prioritization & delegationHard
A patient has full-thickness burns all the way around the chest and is finding it harder to breathe, although the airway is clear. What does this suggest?
AThe burns are healing and the skin is tightening normally
BThe tight burned skin is restricting chest movement, so an escharotomy may be needed
CThe patient has had too little IV fluid and needs a fast bolus to improve the breathing
DThe patient is anxious and only needs reassurance
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · Annual influenza and pneumococcal vaccination
Why this is the answer
Vaccination against influenza, pneumococcus and other respiratory infections recommended in national schedules (such as COVID-19 and, for older adults, RSV) reduces infections and exacerbations in COPD.
Answer
B · Annual influenza and pneumococcal vaccination
2.Med-surg: cardiovascular & respiratory
Answer: D · Record a 12-lead ECG, call senior help and anticipate an antiarrhythmic
Why this is the answer
A broad-complex tachycardia is treated as ventricular tachycardia until proven otherwise. With a pulse and no adverse features (shock, syncope, chest pain or heart failure), a 12-lead ECG, electrolyte correction and drug treatment such as amiodarone are used, with expert help. Unstable patients need synchronised cardioversion; pulseless VT is defibrillated.
Answer
D · Record a 12-lead ECG, call senior help and anticipate an antiarrhythmic
3.Med-surg: neuro, endocrine & renal
Answer: D · Sit the patient fully upright for meals and for a while afterwards
Why this is the answer
Sitting upright during and after meals helps food pass safely and reduces reflux and aspiration. Small mouthfuls, unhurried feeding and the textures advised by the speech and language therapist are also important.
Answer
D · Sit the patient fully upright for meals and for a while afterwards
4.Med-surg: neuro, endocrine & renal
Answer: A · Loss of the outer half of the field in both eyes
Why this is the answer
The chiasm carries crossing fibres from the nasal retinas, which see the temporal (outer) fields. Compression causes a bitemporal hemianopia. Patients may bump into objects at their sides.
Answer
A · Loss of the outer half of the field in both eyes
5.Med-surg: GI, perioperative & oncology
Answer: D · A single room with its own toilet, and soap-and-water handwashing
Why this is the answer
C. difficile forms spores that resist alcohol gel, so soap and water are used. Patients are isolated with their own toilet, staff use gloves and aprons, and the environment is cleaned with a sporicidal agent such as chlorine.
Answer
D · A single room with its own toilet, and soap-and-water handwashing
6.Med-surg: GI, perioperative & oncology
Answer: D · Offload the area, manage moisture, support nutrition and dress it
Why this is the answer
Offloading the sacrum, keeping the skin clean and dry, ensuring adequate protein and calories, and choosing a dressing that keeps a moist healing environment all support healing. Long periods sitting increase sacral pressure.
Answer
D · Offload the area, manage moisture, support nutrition and dress it
7.Clinical nursing
Answer: D · Contact precautions with gloves, apron and good hand hygiene
Why this is the answer
MRSA is spread mainly by direct and indirect contact, so contact precautions, isolation where possible and strict hand hygiene limit transmission.
Answer
D · Contact precautions with gloves, apron and good hand hygiene
8.Clinical nursing
Answer: C · Neurogenic shock
Why this is the answer
Neurogenic shock from cervical or high thoracic injury causes vasodilation and bradycardia because sympathetic outflow is lost. Hypovolaemic shock usually causes tachycardia and cool, pale skin.
Answer
C · Neurogenic shock
9.Lab values & electrolytes
Answer: D · Absolute neutrophil count
Why this is the answer
Clozapine can cause severe neutropenia (agranulocytosis), so the ANC is checked before starting and regularly during treatment. A sore throat, fever or other sign of infection must be reported at once.
Answer
D · Absolute neutrophil count
10.Lab values & electrolytes
Answer: C · Hyperosmolar hyperglycemic state (HHS)
Why this is the answer
HHS causes extreme hyperglycemia and high osmolality with severe dehydration, but enough insulin is present to prevent significant ketosis, so the pH is near normal. DKA has ketones and acidosis; SIADH has low osmolality.Checked against:Ketoacidosis · StatPearls (NCBI Bookshelf) (2023); Osmolality blood test · MedlinePlus (NIH) (2025)
Answer
C · Hyperosmolar hyperglycemic state (HHS)
11.Arterial blood gas interpretation
Answer: PaCO₂ = 32 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·16 + 8 = 32 mmHg
range: 30–34 mmHg
Answer
PaCO₂ = 32 mmHg
12.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·9 + 8 = 21.5 → 19.5–23.5 mmHg
Compare
measured: 32 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
13.ECG rhythm strip interpretation
Answer: QTc = 0.472 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 12.5 × 0.04 = 0.50 s
RR = 28 × 0.04 = 1.12 s
Bazett’s formula
QTc = 0.50/√1.12 = 0.50/1.058 = 0.472 s
Answer
QTc = 0.472 s
Above the usual limits for both men (about 0.45 s) and women (about 0.46 s): prolonged. (472 ms)
14.ECG rhythm strip interpretation
Answer: ventricular paced rhythm
Paced rhythms: a pacemaker impulse shows as a narrow vertical pacing spike. After a ventricular spike the QRS is wide (0.12 s or more), because the impulse spreads from the lead through the muscle instead of the conduction system; with right-ventricular pacing it is often mostly negative in lead II. A spike before each P wave means atrial pacing, and a dual-chamber (AV) pacemaker shows an atrial spike and a P wave, then, after the programmed AV delay, a ventricular spike and a wide QRS. Capture means every spike is followed by a depolarisation. Failure to capture is a spike without a P wave or QRS after it; failure to sense (spikes that ignore the patient’s own beats) and failure to pace (no spike when one is due) are the other classic malfunctions.
Five steps
1. Rate: R–R = 23 small boxes, 1500 ÷ 23 ≈ 65 per minute.
2. Rhythm: regular, every R–R is 0.92 s.
3. P waves: none visible; a sharp pacing spike comes just before every QRS.
4. PR interval: not measurable.
5. QRS: 0.14 s, wide, and every spike is followed by a QRS (capture).
Interpretation
ventricular paced rhythm
Answer
ventricular paced rhythm
The paced QRS is wide by nature; do not call it a bundle branch block or a ventricular rhythm.
15.Prioritization & delegation
Answer: D · Jaundice that appears within the first 24 hours
Why this is the answer
Jaundice in the first 24 hours is not physiological and may point to hemolysis or infection. Mild jaundice after the first day, milia and acrocyanosis are common, expected findings.
Answer
D · Jaundice that appears within the first 24 hours
16.Prioritization & delegation
Answer: B · The tight burned skin is restricting chest movement, so an escharotomy may be needed
Why this is the answer
Circumferential full-thickness burns form stiff eschar that can stop the chest expanding. An escharotomy, cutting through the eschar, may be needed urgently to allow breathing.
Answer
B · The tight burned skin is restricting chest movement, so an escharotomy may be needed