Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with heart failure is comfortable at rest but becomes breathless walking across a room. Which NYHA class fits best?
AClass II
BClass IV
CClass III
DClass I
2.Med-surg: cardiovascular & respiratoryHard
A frightened young woman is breathing fast and has tingling fingers. Her blood gas shows pH 7.50 and a low PaCO₂. SpO₂ is 99% on air. What does this show?
AMetabolic acidosis from kidney failure
BMetabolic alkalosis from vomiting
CRespiratory acidosis from hypoventilation
DRespiratory alkalosis from hyperventilation
3.Med-surg: neuro, endocrine & renalMedium
A patient on ciclosporin or tacrolimus asks about grapefruit juice. Which advice is correct?
AAvoid it, because it can raise the drug levels
BDrink it daily to protect the kidney
CDrink it with each dose to improve the absorption
DIt has no effect on these drugs
4.Med-surg: neuro, endocrine & renalHard
A patient with acromegaly snores loudly, stops breathing at times in sleep and is sleepy during the day. What is most likely?
AAn anxiety disorder
BObstructive sleep apnoea
CNormal snoring
DNarcolepsy
5.Med-surg: GI, perioperative & oncologyMedium
During the first infusion of a monoclonal antibody such as rituximab, which problem is most important to watch for?
ASudden hair loss during the infusion
BSevere constipation within the first hour of starting the infusion
CAn infusion reaction, such as fever, rigors or breathlessness
DA rise in platelet count above normal
6.Med-surg: GI, perioperative & oncologyHard
An older patient with atrial fibrillation has sudden severe abdominal pain, but the abdomen is soft with little tenderness. Lactate is raised. What should the nurse suspect?
AAcute mesenteric ischaemia
BSimple constipation
CIrritable bowel syndrome
DMuscle strain from coughing
7.Clinical nursingMedium
In suspected sepsis, what should ideally be collected before the first dose of antibiotics, as long as it does not delay treatment?
AA stool sample for occult blood
BA fasting cholesterol level
CBlood cultures
DA 24-hour urine collection
8.Clinical nursingHard
A patient with known cirrhosis suddenly vomits large amounts of bright red blood and becomes tachycardic. What is the most likely cause?
AA Mallory-Weiss tear from a small amount of vomiting
BA lower GI bleed from diverticular disease
CBleeding from ruptured oesophageal varices
DSwallowed blood from a nosebleed
9.Lab values & electrolytesMedium
A patient with diabetes is found unconscious with a blood glucose of 38 mg/dL (2.1 mmol/L). Which treatment is appropriate?
AA dose of rapid-acting insulin to stabilize the glucose
BOrange juice poured slowly into the patient's mouth
CGlucose tablets placed between the patient's teeth
DGlucagon by injection, or IV dextrose as prescribed
10.Lab values & electrolytesHard
The nurse teaches a patient with iron-deficiency anemia who is starting oral iron. Which statement shows a need for further teaching?
A"I can take it with orange juice to help absorption"
B"I'll keep the tablets out of reach of the children"
C"I'll take my iron tablet with a big glass of milk"
D"My stools may look darker while I take the tablets"
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 135 mmol/L, glucose 31.2 mmol/L and urea 6.9 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 135 mmol/Lglucose 31.2 mmol/Lurea 6.9 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 30% oxygen shows PaO₂ 55 mmHg (7.3 kPa) and PaCO₂ 59 mmHg (7.9 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus bradycardia
2sinus tachycardia
3normal sinus rhythm
4first-degree AV block
14.ECG rhythm strip interpretationHard
This lead II strip shows an AV block with an irregular ventricular rhythm. Use the 6-second method to find the ventricular rate in beats per minute.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
ventricular rate = bpm
15.Prioritization & delegationMedium
On day 3 after hip surgery, a patient suddenly becomes short of breath with sharp chest pain and an SpO₂ of 88%. What should the nurse do first?
AGive the next dose of oral analgesia and reassess the patient in an hour
BRaise the head of the bed, give oxygen and call for urgent help
CMassage the patient’s calves to ease any muscle cramp
DEncourage the patient to walk to improve the circulation
16.Prioritization & delegationHard
A patient has central chest pain that started 30 minutes ago at rest and has not eased with rest or nitroglycerin. What does this suggest?
AStable angina that will pass without treatment
BMuscle strain that needs a warm compress
CA possible myocardial infarction that needs urgent action
DIndigestion that is best treated with an antacid and a glass of milk
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Class III
Why this is the answer
NYHA class I has no limitation, class II slight limitation with ordinary activity, class III marked limitation with less than ordinary activity but comfortable at rest, and class IV symptoms at rest. The class guides treatment and prognosis.
Answer
C · Class III
2.Med-surg: cardiovascular & respiratory
Answer: D · Respiratory alkalosis from hyperventilation
Why this is the answer
Hyperventilation blows off CO₂, causing respiratory alkalosis. The alkalosis lowers ionised calcium, causing tingling and carpopedal spasm. Normal oxygen saturation is reassuring, but organic causes such as PE, asthma or diabetic ketoacidosis must still be excluded.
Answer
D · Respiratory alkalosis from hyperventilation
3.Med-surg: neuro, endocrine & renal
Answer: A · Avoid it, because it can raise the drug levels
Why this is the answer
Grapefruit inhibits the CYP3A4 enzyme and can raise ciclosporin and tacrolimus levels, leading to toxicity. Patients are advised to avoid it, and to check before starting any new medicine or supplement.
Answer
A · Avoid it, because it can raise the drug levels
4.Med-surg: neuro, endocrine & renal
Answer: B · Obstructive sleep apnoea
Why this is the answer
Growth hormone excess enlarges the tongue and upper airway tissues, so obstructive sleep apnoea is common in acromegaly. It needs assessment because it raises cardiovascular risk and affects safety under anaesthesia.
Answer
B · Obstructive sleep apnoea
5.Med-surg: GI, perioperative & oncology
Answer: C · An infusion reaction, such as fever, rigors or breathlessness
Why this is the answer
Infusion-related reactions are most common with the first dose. Premedication, a slow starting rate, close monitoring and readiness to stop the infusion and treat anaphylaxis are standard.
Answer
C · An infusion reaction, such as fever, rigors or breathlessness
6.Med-surg: GI, perioperative & oncology
Answer: A · Acute mesenteric ischaemia
Why this is the answer
An embolus from AF can block the mesenteric artery, causing bowel ischaemia. Early signs are severe pain with few findings; raised lactate and peritonitis appear as the bowel dies. It needs urgent CT and surgery.
Answer
A · Acute mesenteric ischaemia
7.Clinical nursing
Answer: C · Blood cultures
Why this is the answer
Blood cultures taken before antibiotics are more likely to grow the organism, which allows targeted treatment later. Antibiotics should still be given promptly and must not be delayed.
Answer
C · Blood cultures
8.Clinical nursing
Answer: C · Bleeding from ruptured oesophageal varices
Why this is the answer
Portal hypertension in cirrhosis causes oesophageal varices, which can bleed massively. This needs resuscitation, urgent endoscopy and specific drug treatment.
Answer
C · Bleeding from ruptured oesophageal varices
9.Lab values & electrolytes
Answer: D · Glucagon by injection, or IV dextrose as prescribed
Why this is the answer
A patient who cannot swallow safely must not receive anything by mouth because of the risk of aspiration. Glucagon (injected or intranasal) or IV dextrose raises the glucose; once awake and able to swallow, the patient is given oral carbohydrate and a snack.Checked against:Hypoglycemia · MedlinePlus (NIH); Low blood sugar · MedlinePlus (NIH) (2026)
Answer
D · Glucagon by injection, or IV dextrose as prescribed
10.Lab values & electrolytes
Answer: C · "I'll take my iron tablet with a big glass of milk"
Why this is the answer
Calcium in milk, as well as antacids and tea, reduces iron absorption, so iron should not be taken with them. Vitamin C improves absorption, dark stools are expected, and iron overdose is a serious poisoning risk in young children.Checked against:Iron deficiency anemia - Medical Encyclopedia · MedlinePlus (NIH) (2025); Iron in diet - Medical Encyclopedia · MedlinePlus (NIH) (2025)
Answer
C · "I'll take my iron tablet with a big glass of milk"
11.Arterial blood gas interpretation
Answer: Osm = 308 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·135 + 31.2 + 6.9 = 308.1 ≈ 308 mOsm/kg
Answer
Osm = 308 mOsm/kg
12.Arterial blood gas interpretation
Answer: A–a gradient = 85.15 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 23 small boxes, 1500 ÷ 23 ≈ 65 per minute.
2. Rhythm: regular, every R–R is 0.92 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.24 s, constant, longer than 0.20 s.
5. QRS: 0.08 s, narrow (below 0.12 s).
Interpretation
first-degree AV block
Answer
first-degree AV block
14.ECG rhythm strip interpretation
Answer: ventricular rate = 50 bpm
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Atrial rate
P–P = 21 small boxes = 0.84 s → 1500 ÷ 21 = 71.43 ≈ 71 per minute
Ventricular rate
5 QRS complexes in 6 s × 10 = 50 per minute
Answer
ventricular rate = 50 bpm
Answer
ventricular rate = 50 bpm
Second-degree type II: 4 P waves for every 3 QRS complexes, with a constant PR.
15.Prioritization & delegation
Answer: B · Raise the head of the bed, give oxygen and call for urgent help
Why this is the answer
Sudden breathlessness and chest pain after surgery suggest a pulmonary embolism. The nurse supports breathing with positioning and oxygen and escalates at once; walking or leg massage could make things worse.
Answer
B · Raise the head of the bed, give oxygen and call for urgent help
16.Prioritization & delegation
Answer: C · A possible myocardial infarction that needs urgent action
Why this is the answer
Chest pain that lasts and is not relieved by rest or nitroglycerin suggests acute coronary syndrome, possibly a heart attack. The nurse acts at once: ECG, escalation and prescribed treatment.
Answer
C · A possible myocardial infarction that needs urgent action