Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient is starting doxazosin, an alpha-blocker, for hypertension. Which advice is most important?
AAvoid all potassium-containing foods
BTake it with a large glass of grapefruit juice to improve absorption
CStop it suddenly if the heart rate rises after the first few doses
DTake the first dose at bedtime, as dizziness and fainting can occur
2.Med-surg: cardiovascular & respiratoryHard
Which method best confirms that an endotracheal tube is in the trachea?
AThe patient's skin colour improving
BThe chest rising on one side only
CMisting inside the tube
DA sustained waveform on capnography
3.Med-surg: neuro, endocrine & renalMedium
Which group of problems is typical of primary hyperparathyroidism?
AHair loss, weight gain and feeling cold
BKidney stones, bone pain, abdominal pain and low mood
CHeat intolerance, tremor, weight loss and diarrhoea
DMuscle cramps, tingling lips and seizures
4.Med-surg: neuro, endocrine & renalHard
A patient with a subarachnoid haemorrhage develops a low sodium. Why is fluid restriction usually avoided in this patient?
AFluid restriction raises the risk of seizures
BFluid restriction would cause the aneurysm to re-bleed
CLow sodium in this condition always corrects itself
DLow blood volume can worsen vasospasm and brain ischaemia
5.Med-surg: GI, perioperative & oncologyMedium
Which technique is correct when giving a prefilled low molecular weight heparin injection?
AExpel the air bubble first and inject into the deltoid muscle
BInject into a vein in the back of the hand
CRub the site firmly afterwards to help absorption
DLeave the air bubble in and inject into a skin fold
6.Med-surg: GI, perioperative & oncologyHard
A 62-year-old with known reflux reports burning central chest pain with sweating and breathlessness that began while walking. What should the nurse do first?
ABook a routine endoscopy for later in the week
BGive an antacid and reassess the pain in an hour
CAdvise the patient to avoid spicy food at future meals
DRecord a 12-lead ECG and escalate as possible cardiac pain
7.Clinical nursingMedium
An older patient is at high risk of falls on the ward. Which nursing action is most appropriate?
AKeep the call bell and belongings within reach and review medicines that cause drowsiness
BUse bed rails for every patient automatically
CRestrict the patient to bed at all times
DRemove the patient's glasses to prevent breakage
8.Clinical nursingHard
A patient with a confirmed pulmonary embolism is started on anticoagulation. Which statement best explains its purpose?
AIt dissolves the clot completely within minutes of the first dose being given
BIt stops the clot growing and prevents new clots while the body breaks it down
CIt thins the blood so that the lungs absorb more oxygen
DIt is mainly given to lower the blood pressure
9.Lab values & electrolytesMedium
A patient has taken a proton pump inhibitor (such as omeprazole) for many years and now has muscle cramps and tremor. Which electrolyte is most likely to be low?
ASodium
BMagnesium
CPhosphate
DChloride
10.Lab values & electrolytesHard
After a crush injury, a patient's urine dipstick is strongly positive for blood, but microscopy shows almost no red cells. CK is very high. What best explains this?
ABleeding is coming from the bladder lining
BA kidney stone is scraping the ureter lining
CMyoglobin from damaged muscle is in the urine
DThe sample was contaminated with menstrual blood
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 139 mmol/L, glucose 21.6 mmol/L and urea 7.6 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 139 mmol/Lglucose 21.6 mmol/Lurea 7.6 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.16, PaCO₂ 32 mmHg (4.3 kPa), HCO₃⁻ 11 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.16PaCO₂ 32 mmHg (4.3 kPa)HCO₃⁻ 11 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Interpret this lead II strip with the five steps in order: rate, rhythm, P waves, PR interval, QRS duration. At which step do you find the first abnormal finding? Click it.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1rate
2rhythm
3P waves
4PR interval
5QRS duration
15.Prioritization & delegationMedium
Which patient with diabetes should the nurse see first?
AHbA1c result of 8.2%, asking about diet
BGlucose 210 mg/dL (11.7 mmol/L) after a large lunch, feels well
CNeeds foot care teaching before discharge tomorrow
DGlucose 48 mg/dL (2.7 mmol/L), sweating and confused
16.Prioritization & delegationHard
A patient opens their eyes only to pain, uses inappropriate words and withdraws from pain. What is the Glasgow Coma Scale score?
A7
B11
C13
D9
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · Take the first dose at bedtime, as dizziness and fainting can occur
Why this is the answer
Alpha-blockers can cause marked first-dose postural hypotension. Taking the first dose at bedtime and rising slowly reduces the risk of falls. They are also used for symptoms of an enlarged prostate.
Answer
D · Take the first dose at bedtime, as dizziness and fainting can occur
2.Med-surg: cardiovascular & respiratory
Answer: D · A sustained waveform on capnography
Why this is the answer
A sustained exhaled carbon dioxide waveform confirms tracheal placement. Misting and chest movement can be misleading, and skin colour changes late. A chest X-ray shows the depth of the tube but does not prove it is in the trachea.
Answer
D · A sustained waveform on capnography
3.Med-surg: neuro, endocrine & renal
Answer: B · Kidney stones, bone pain, abdominal pain and low mood
Why this is the answer
High PTH raises calcium, which can cause kidney stones, bone loss and pain, constipation and abdominal pain, and low mood or confusion ("stones, bones, groans and moans"). Many cases are found on routine blood tests.
Answer
B · Kidney stones, bone pain, abdominal pain and low mood
4.Med-surg: neuro, endocrine & renal
Answer: D · Low blood volume can worsen vasospasm and brain ischaemia
Why this is the answer
Hyponatraemia after subarachnoid haemorrhage may come from SIADH or cerebral salt wasting. Restricting fluid can cause hypovolaemia, which makes delayed cerebral ischaemia more likely. Sodium is usually corrected with fluids or salt under specialist advice.
Answer
D · Low blood volume can worsen vasospasm and brain ischaemia
5.Med-surg: GI, perioperative & oncology
Answer: D · Leave the air bubble in and inject into a skin fold
Why this is the answer
LMWH is injected into a pinched skin fold, often on the abdomen, away from the umbilicus. The air bubble in prefilled syringes is left in, and the site is not rubbed, to reduce bruising.
Answer
D · Leave the air bubble in and inject into a skin fold
6.Med-surg: GI, perioperative & oncology
Answer: D · Record a 12-lead ECG and escalate as possible cardiac pain
Why this is the answer
Cardiac pain can feel like heartburn. Exertional pain with sweating and breathlessness must be treated as possible acute coronary syndrome until excluded, so an ECG and urgent review come first.
Answer
D · Record a 12-lead ECG and escalate as possible cardiac pain
7.Clinical nursing
Answer: A · Keep the call bell and belongings within reach and review medicines that cause drowsiness
Why this is the answer
Falls prevention includes assessing risk factors, reviewing sedating drugs, providing glasses, footwear and walking aids, keeping essentials in reach and supporting toileting.
Answer
A · Keep the call bell and belongings within reach and review medicines that cause drowsiness
8.Clinical nursing
Answer: B · It stops the clot growing and prevents new clots while the body breaks it down
Why this is the answer
Anticoagulants prevent clot extension and new clots; the body's own fibrinolysis gradually breaks down the existing clot. Thrombolysis, which actively dissolves clots, is reserved for massive PE with shock.
Answer
B · It stops the clot growing and prevents new clots while the body breaks it down
Answer: C · Myoglobin from damaged muscle is in the urine
Why this is the answer
The dipstick blood test detects heme, which is present in both hemoglobin and myoglobin. Positive "blood" without red cells, together with a very high CK, indicates myoglobinuria from rhabdomyolysis, which can damage the kidneys. IV fluids and close monitoring of urine output and potassium are needed.Checked against:Myoglobin urine test · MedlinePlus (NIH) (2025); Rhabdomyolysis · MedlinePlus (NIH) (2025); Creatine Kinase · MedlinePlus (NIH) (2023)
Answer
C · Myoglobin from damaged muscle is in the urine
11.Arterial blood gas interpretation
Answer: Osm = 307 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·139 + 21.6 + 7.6 = 307.2 ≈ 307 mOsm/kg
Answer
Osm = 307 mOsm/kg
12.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·11 + 8 = 24.5 → 22.5–26.5 mmHg
Compare
measured: 32 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
13.ECG rhythm strip interpretation
Answer: QTc = 0.491 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 13 × 0.04 = 0.52 s
RR = 28 × 0.04 = 1.12 s
Bazett’s formula
QTc = 0.52/√1.12 = 0.52/1.058 = 0.491 s
Answer
QTc = 0.491 s
Above the usual limits for both men (about 0.45 s) and women (about 0.46 s): prolonged. (491 ms)
14.ECG rhythm strip interpretation
Answer: P waves
Five steps for every strip: 1. rate (300 or 1500 method, or the 6-second method if irregular); 2. rhythm: are the R–R intervals equal; 3. P waves: present, upright in lead II, one before every QRS and all alike; 4. PR interval: 0.12–0.20 s and constant; 5. QRS duration: below 0.12 s. Only after the five steps name the rhythm. Normal sinus rhythm passes all five: 60–100/min, regular, upright P before every QRS, PR 0.12–0.20 s, QRS below 0.12 s.
Five steps
1. Rate: R–R = 19 small boxes, 1500 ÷ 19 ≈ 79 per minute.
2. Rhythm: regular, every R–R is 0.76 s.
3. P waves: inverted, just before each QRS.
4. PR interval: 0.10 s, shorter than 0.12 s.
5. QRS: 0.08 s, narrow (below 0.12 s).
First abnormal step
P waves → accelerated junctional rhythm
Answer
P waves
15.Prioritization & delegation
Answer: D · Glucose 48 mg/dL (2.7 mmol/L), sweating and confused
Why this is the answer
Severe hypoglycemia with confusion can quickly lead to seizures and loss of consciousness. The other patients have problems that matter but are not immediately dangerous.
Answer
D · Glucose 48 mg/dL (2.7 mmol/L), sweating and confused
16.Prioritization & delegation
Answer: D · 9
Why this is the answer
Eyes open to pain scores 2, inappropriate words score 3 and withdrawal from pain scores 4, giving 9. A score of 8 or less often means the patient cannot protect their airway.