Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with an implantable cardioverter-defibrillator asks what to do if it fires. Which teaching is correct?
AOne shock and well: contact the device clinic; repeated shocks or unwell: call emergency services
BRemove the device battery at home if it fires more than once
CDrive straight to hospital alone after any shock so the device can be checked by the team
DIgnore any shock at all, because the device is designed to fire every day and needs no follow-up
2.Med-surg: cardiovascular & respiratoryHard
A patient with COPD is going home on long-term oxygen. Which teaching point is most important for safety?
AStore spare cylinders next to the cooker
BUse petroleum jelly to soothe dry nostrils
CNever smoke or allow open flames near the oxygen
DTurn the flow up as high as needed when breathless
3.Med-surg: neuro, endocrine & renalMedium
A seizure has lasted five minutes and is continuing. What is the usual first-line drug treatment?
AIV glucose 50% in every patient, then reassess
BAn IV loading dose of phenytoin before anything else
CA benzodiazepine such as IV lorazepam or buccal midazolam
DIM adrenaline into the outer thigh
4.Med-surg: neuro, endocrine & renalHard
A woman with epilepsy who takes valproate says she is planning a pregnancy. Which response is most appropriate?
AAdvise not stopping it suddenly and urgent specialist review
BReassure her that valproate is safe throughout pregnancy
CSuggest doubling the dose to protect the baby from seizures
DTell her to stop taking the valproate completely from today
5.Med-surg: GI, perioperative & oncologyMedium
Dysphagia that started with solids and now includes liquids, with weight loss, most suggests which cause?
AA narrowing such as an oesophageal tumour
BSimple anxiety about swallowing tablets
CA dry mouth from drinking too little water
DNormal ageing of the swallowing muscles
6.Med-surg: GI, perioperative & oncologyHard
A patient arrives in the anaesthetic room without an identity band. What should the nurse do?
AProceed because the patient can say their name
BStop and confirm identity, then apply a band
CUse the spare identity band from the front of the patient's notes folder
DProceed and add a band once in recovery
7.Clinical nursingMedium
A patient is prescribed two different eye drops at the same time. What is correct?
AGive both drops at once into the same eye
BWait about five minutes between the two drops
CMix the two drops in one bottle
DGive one drop now and the other the next day
8.Clinical nursingHard
After a head injury, a patient passes very large volumes of dilute urine and the serum sodium is rising. What is most likely?
AAcute kidney injury
BSyndrome of inappropriate ADH secretion
CDiabetes mellitus
DDiabetes insipidus
9.Lab values & electrolytesMedium
A patient has a hot, swollen big toe. The serum uric acid is normal. Which statement is correct?
AGout is still possible, as urate can be normal in an attack
BGout is certain, as a normal urate proves the diagnosis
CGout is ruled out, as uric acid is always high in an attack
DGout can only be diagnosed with a CT scan of the foot
10.Lab values & electrolytesHard
A patient has a sodium of 150 mEq/L, a glucose of 180 mg/dL and a BUN of 28 mg/dL. Using the formula 2 × Na + glucose/18 + BUN/2.8, what is the calculated serum osmolality?
AAbout 320 mOsm/kg, which is high
BAbout 358 mOsm/kg, which is high
CAbout 300 mOsm/kg, which is normal
DAbout 285 mOsm/kg, which is normal
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 26 mmHg (3.5 kPa). Use the rule that in chronic respiratory alkalosis HCO₃⁻ falls by 5 mmol/L for every 10 mmHg that PaCO₂ is below 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
At sea level, a practice gas taken on 21% oxygen shows PaO₂ 92 mmHg (12.3 kPa) and PaCO₂ 37 mmHg (4.9 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
A monitored patient is found unresponsive and not breathing normally, and no carotid pulse can be felt. The monitor shows this organised rhythm. What is this situation called? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1ventricular fibrillation
2normal sinus rhythm
3pulseless electrical activity (PEA)
4asystole
15.Prioritization & delegationMedium
Which nursing assistant task is appropriate for a patient two days after hip replacement?
AEvaluating whether the last dose of pain medication controlled the pain
BChecking the incision for redness, warmth and drainage
CTeaching the patient the hip precautions before discharge
DHelping the patient into a chair, following the hip precautions
16.Prioritization & delegationHard
On a cardiac step-down unit, which patient should the nurse assess first?
ASix hours after a coronary stent, new chest pain with ST elevation on the monitor
BHeart failure, weight up 0.5 kg since yesterday, no breathlessness at rest
CAtrial fibrillation on warfarin with an INR of 2.6 this morning
DDay 2 after a pacemaker insertion, asking when the wound dressing will be changed
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · One shock and well: contact the device clinic; repeated shocks or unwell: call emergency services
Why this is the answer
A single shock with full recovery usually needs a call to the device team. Several shocks in a short time, or a shock with chest pain, breathlessness or collapse, needs emergency help. Patients should not drive themselves after a shock.
Answer
A · One shock and well: contact the device clinic; repeated shocks or unwell: call emergency services
2.Med-surg: cardiovascular & respiratory
Answer: C · Never smoke or allow open flames near the oxygen
Why this is the answer
Smoking while using oxygen is a major cause of burns and fatal fires. Patients must keep oxygen away from flames and heat sources, use water-based (not oil-based) lubricants and follow the prescribed flow, because unsupervised increases can worsen CO₂ retention.
Answer
C · Never smoke or allow open flames near the oxygen
3.Med-surg: neuro, endocrine & renal
Answer: C · A benzodiazepine such as IV lorazepam or buccal midazolam
Why this is the answer
A seizure lasting five minutes or more (or repeated seizures without recovery) is treated as status epilepticus. A benzodiazepine is given first (IV lorazepam if access is available; buccal or intranasal midazolam or rectal diazepam if not), then a second-line antiseizure drug such as levetiracetam, phenytoin or valproate if the seizure continues. Glucose is checked and given only if low.
Answer
C · A benzodiazepine such as IV lorazepam or buccal midazolam
4.Med-surg: neuro, endocrine & renal
Answer: A · Advise not stopping it suddenly and urgent specialist review
Why this is the answer
Valproate is highly teratogenic (neural tube defects and neurodevelopmental problems), and its use in people who could become pregnant is tightly restricted. However, stopping antiseizure medication suddenly risks status epilepticus. Urgent specialist review to plan a safer alternative, plus folic acid supplementation, is needed.
Answer
A · Advise not stopping it suddenly and urgent specialist review
5.Med-surg: GI, perioperative & oncology
Answer: A · A narrowing such as an oesophageal tumour
Why this is the answer
Progressive dysphagia, solids first then liquids, with weight loss, is typical of a mechanical obstruction such as oesophageal cancer or a stricture. It needs an urgent referral for endoscopy.
Answer
A · A narrowing such as an oesophageal tumour
6.Med-surg: GI, perioperative & oncology
Answer: B · Stop and confirm identity, then apply a band
Why this is the answer
Correct identification before anaesthesia prevents wrong-patient surgery. The process stops until identity is confirmed with the patient and records and a band is applied, following the checklist.
Answer
B · Stop and confirm identity, then apply a band
7.Clinical nursing
Answer: B · Wait about five minutes between the two drops
Why this is the answer
Leaving a few minutes between different drops lets each one be absorbed. Gentle pressure on the inner corner of the eye can also reduce systemic absorption.
Answer
B · Wait about five minutes between the two drops
8.Clinical nursing
Answer: D · Diabetes insipidus
Why this is the answer
Cranial diabetes insipidus is a lack of ADH, so the kidneys cannot concentrate urine. Water loss raises sodium; strict fluid balance and replacement are needed.
Answer
D · Diabetes insipidus
9.Lab values & electrolytes
Answer: A · Gout is still possible, as urate can be normal in an attack
Why this is the answer
Serum urate can be normal or even low during an acute gout attack. The definitive test is joint aspiration showing needle-shaped urate crystals, which also helps rule out septic arthritis.Checked against:Gout · MedlinePlus (NIH) (2025); Synovial Fluid Analysis · MedlinePlus (NIH) (2024)
Answer
A · Gout is still possible, as urate can be normal in an attack
10.Lab values & electrolytes
Answer: A · About 320 mOsm/kg, which is high
Why this is the answer
Osmolality = 300 + 10 + 10 = 320 mOsm/kg, above the typical range of about 275–295 mOsm/kg. The high sodium is the main cause, which points to water loss or too little water intake.Checked against:Osmolality blood test · MedlinePlus (NIH) (2025)
Answer
A · About 320 mOsm/kg, which is high
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 17 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|26 − 40| = 14 mmHg → 1.4 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 − 5·1.4 = 17 mmol/L
Answer
HCO₃⁻ = 17 mmol/L
12.Arterial blood gas interpretation
Answer: A–a gradient = 11.48 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 11 × 0.04 = 0.44 s
RR = 23 × 0.04 = 0.92 s
Fridericia’s formula
QTc = 0.44/∛0.92 = 0.44/0.9726 = 0.452 s
Answer
QTc = 0.452 s
Between the usual limits for men (about 0.45 s) and women (about 0.46 s): borderline, depending on the reference used. (452 ms)
14.ECG rhythm strip interpretation
Answer: pulseless electrical activity (PEA)
Pulseless electrical activity (PEA): PEA cannot be seen on a strip. The monitor shows organised electrical activity (a rhythm other than VF, VT or asystole) but the patient has no palpable pulse, so it is recognised by checking the patient. In adult resuscitation guidelines PEA and asystole are the non-shockable cardiac arrest rhythms: high-quality CPR, epinephrine as soon as possible and a search for reversible causes (the Hs and Ts, such as hypovolaemia, hypoxia, tension pneumothorax and cardiac tamponade). VF and pulseless VT are the shockable rhythms.
What the strip shows
1. Rate: R–R = 20 small boxes, 1500 ÷ 20 ≈ 75 per minute.
2. Rhythm: regular, every R–R is 0.80 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.12 s, constant, within 0.12–0.20 s.
5. QRS: 0.10 s, narrow (below 0.12 s).
normal sinus rhythm
What the patient shows
no pulse despite organised electrical activity: pulseless electrical activity (PEA), a non-shockable cardiac arrest rhythm
Answer
pulseless electrical activity (PEA)
Answer
pulseless electrical activity (PEA)
PEA is recognised at the bedside, never from the strip alone. This is exam practice, not clinical guidance.
15.Prioritization & delegation
Answer: D · Helping the patient into a chair, following the hip precautions
Why this is the answer
Helping a stable patient move, using precautions already set in the care plan, is a routine task. Inspecting the wound, teaching and evaluating pain relief need nursing assessment.
Answer
D · Helping the patient into a chair, following the hip precautions
16.Prioritization & delegation
Answer: A · Six hours after a coronary stent, new chest pain with ST elevation on the monitor
Why this is the answer
New chest pain with ST elevation after a stent suggests the stent may have blocked, causing an acute myocardial infarction. This is an emergency; the other findings are within target or routine.
Answer
A · Six hours after a coronary stent, new chest pain with ST elevation on the monitor