Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Why should a long-acting beta-2 agonist (LABA) never be used alone in asthma?
AIt works only when it is taken together with a course of antibiotics
BWithout an inhaled steroid, it is linked with severe and fatal attacks
CIt cannot be inhaled without a nebuliser
DIt always causes immediate severe bronchospasm when used on its own
2.Med-surg: cardiovascular & respiratoryHard
A conscious adult in the dining room is suddenly unable to speak, cough or breathe after a mouthful of food. What should the nurse do first?
ASweep blindly in the mouth with a finger
BEncourage them to drink a glass of water to wash the food down
CUp to five back blows, then up to five abdominal thrusts if needed
DLie them down on the floor and start chest compressions immediately
3.Med-surg: neuro, endocrine & renalMedium
Where is the zero point of an external ventricular drain usually levelled?
AAt the level of the umbilicus
BAt the top of the head
CAt the mid-axillary line of the chest
DAt the tragus of the ear
4.Med-surg: neuro, endocrine & renalHard
An older man was found on the floor after lying there for many hours. His urine is dark brown, and his creatine kinase is very high. What is the main kidney risk and the key treatment?
AAKI from rhabdomyolysis, treated with generous IV fluids
BA kidney stone, treated with strong pain relief
CHypothermia, treated with a fluid restriction
DA urinary infection, treated with oral antibiotics only
5.Med-surg: GI, perioperative & oncologyMedium
Which advice has good evidence for reducing cancer-related fatigue?
AComplete bed rest for the whole course of treatment
BAvoiding all daily activities
CRegular light to moderate activity, such as walking
DDrinking several strong coffees every evening
6.Med-surg: GI, perioperative & oncologyHard
A nurse teaches a patient about a fentanyl skin patch. Which statement shows a need for further teaching?
A"I'll put the new patch on a different area of skin."
B"I can cut the patch in half if I need less."
C"I'll fold used patches sticky sides together before disposal."
D"I won't put a hot water bottle over the patch."
7.Clinical nursingMedium
A rising serum creatinine most often indicates:
AReduced kidney function
BIncreased muscle strength
CDehydration of the skin only
DImproved liver function
8.Clinical nursingHard
A postoperative patient on IV fluids has a sodium of 128 mmol/L and is becoming confused. Which fluid could make this worse if given in large amounts?
A5% glucose (D5W)
B0.9% sodium chloride
CHartmann's solution (similar to lactated Ringer's)
DHuman albumin solution
9.Lab values & electrolytesMedium
A patient is starting dabigatran, a direct oral anticoagulant. Which laboratory test is most important to review before the first dose?
ATSH, to rule out an overactive thyroid gland
BLipase, to rule out an inflamed pancreas first
CINR, to set the dose of the anticoagulant
DKidney function (creatinine clearance)
10.Lab values & electrolytesHard
During an IV magnesium sulfate infusion, which assessment best detects toxicity early?
ASkin color and capillary refill every hour
BKnee reflexes, respiratory rate and urine output
CBlood glucose and pupil size every hour
DBowel sounds and abdominal girth
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.44, PaCO₂ 29 mmHg (3.9 kPa) and HCO₃⁻ 19 mmol/L. The primary disorder is respiratory alkalosis. How far is it compensated? Click your answer.
pH 7.44PaCO₂ 29 mmHg (3.9 kPa)HCO₃⁻ 19 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 136, Cl⁻ 103 and HCO₃⁻ 17 mmol/L. Calculate the delta ratio (AG − 12)/(24 − HCO₃⁻), using AG = Na⁺ − (Cl⁻ + HCO₃⁻). Give two decimals.
Na⁺ 136 mmol/LCl⁻ 103 mmol/LHCO₃⁻ 17 mmol/L
delta ratio =
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Interpret this lead II strip with the five steps in order: rate, rhythm, P waves, PR interval, QRS duration. At which step do you find the first abnormal finding? Click it.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1rate
2rhythm
3P waves
4PR interval
5QRS duration
15.Prioritization & delegationMedium
A nursing assistant tells the RN that a patient’s IV pump is alarming. What is the best response?
A“Turn the pump off and on again until it stops.”
B“Silence the alarm and I will check it at the end of the shift.”
C“Increase the rate a little so the alarm clears.”
D“I will come and check the pump and the IV site now.”
16.Prioritization & delegationHard
On a surgical unit, which postoperative patient should the nurse see first?
A2 days after colostomy formation: stoma moist and pink, small amount of output
B2 days after hip replacement: pain 5/10 on moving, analgesic given 1 hour ago
CAfter prostate surgery with bladder irrigation: light pink urine, no clots
D6 hours after carotid endarterectomy: neck swelling increasing, says it is hard to swallow
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · Without an inhaled steroid, it is linked with severe and fatal attacks
Why this is the answer
LABA monotherapy in asthma is linked with severe attacks and asthma deaths because it relieves symptoms while airway inflammation continues. In asthma, LABAs are always given with an inhaled corticosteroid, often in one combination inhaler.
Answer
B · Without an inhaled steroid, it is linked with severe and fatal attacks
2.Med-surg: cardiovascular & respiratory
Answer: C · Up to five back blows, then up to five abdominal thrusts if needed
Why this is the answer
For a conscious adult with severe choking, current UK, European and AHA (2025) guidance teach up to five back blows, then up to five abdominal thrusts, repeated until the obstruction clears; some older courses used abdominal thrusts alone. If the person becomes unconscious, CPR is started. Blind finger sweeps can push the object further in.
Answer
C · Up to five back blows, then up to five abdominal thrusts if needed
3.Med-surg: neuro, endocrine & renal
Answer: D · At the tragus of the ear
Why this is the answer
The EVD is levelled at the tragus, which approximates the foramen of Monro. If the head of the bed is changed, the drain must be re-levelled, because its height decides how much CSF drains.
Answer
D · At the tragus of the ear
4.Med-surg: neuro, endocrine & renal
Answer: A · AKI from rhabdomyolysis, treated with generous IV fluids
Why this is the answer
Prolonged pressure damages muscle (rhabdomyolysis), releasing myoglobin, which is toxic to the tubules, as well as potassium. Early, generous IV fluids with close monitoring of urine output, potassium and creatinine help protect the kidneys.
Answer
A · AKI from rhabdomyolysis, treated with generous IV fluids
5.Med-surg: GI, perioperative & oncology
Answer: C · Regular light to moderate activity, such as walking
Why this is the answer
Exercise, matched to ability, reduces cancer-related fatigue. Pacing, prioritising activities, sleep routines and treating causes such as anaemia or depression also help.
Answer
C · Regular light to moderate activity, such as walking
6.Med-surg: GI, perioperative & oncology
Answer: B · "I can cut the patch in half if I need less."
Why this is the answer
Cutting a fentanyl patch can release the drug unpredictably and cause overdose. Heat increases absorption, used patches still contain drug and must be folded and disposed of safely, and sites are rotated.
Answer
B · "I can cut the patch in half if I need less."
7.Clinical nursing
Answer: A · Reduced kidney function
Why this is the answer
Creatinine is a muscle waste product filtered by the kidneys. A rise shows the glomerular filtration rate is falling, as in acute kidney injury.
Answer
A · Reduced kidney function
8.Clinical nursing
Answer: A · 5% glucose (D5W)
Why this is the answer
The glucose in 5% glucose is metabolised, leaving free water that dilutes the plasma sodium further. Postoperative patients often have raised ADH, so large volumes of hypotonic fluid can cause dangerous hyponatraemia.
Answer
A · 5% glucose (D5W)
9.Lab values & electrolytes
Answer: D · Kidney function (creatinine clearance)
Why this is the answer
Dabigatran is excreted mainly by the kidneys, so poor kidney function raises the drug level and bleeding risk. Kidney function is checked before starting and regularly afterwards. Routine INR monitoring is not used for direct oral anticoagulants.
Answer
D · Kidney function (creatinine clearance)
10.Lab values & electrolytes
Answer: B · Knee reflexes, respiratory rate and urine output
Why this is the answer
Loss of the knee reflex is usually the first sign of magnesium toxicity, followed by slow breathing. Magnesium is cleared by the kidneys, so falling urine output increases the risk. Calcium gluconate is the antidote.
Answer
B · Knee reflexes, respiratory rate and urine output
11.Arterial blood gas interpretation
Answer: fully compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.44: within 7.35–7.45
PaCO₂ 29 mmHg: low (35–45)
HCO₃⁻ 19 mmol/L: low (22–26)
Compensation
fully compensated
Answer
fully compensated
12.Arterial blood gas interpretation
Answer: delta ratio = 0.5714
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 136 − (103 + 17) = 16
Delta ratio
(16 − 12)/(24 − 17) = 4/7 = 0.5714
Answer
delta ratio = 0.5714
Below 1: an added normal anion gap acidosis.
13.ECG rhythm strip interpretation
Answer: QTc = 0.451 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9.5 × 0.04 = 0.38 s
RR = 15 × 0.04 = 0.60 s
Fridericia’s formula
QTc = 0.38/∛0.60 = 0.38/0.8434 = 0.451 s
Answer
QTc = 0.451 s
Between the usual limits for men (about 0.45 s) and women (about 0.46 s): borderline, depending on the reference used. (451 ms)
14.ECG rhythm strip interpretation
Answer: rhythm
Five steps for every strip: 1. rate (300 or 1500 method, or the 6-second method if irregular); 2. rhythm: are the R–R intervals equal; 3. P waves: present, upright in lead II, one before every QRS and all alike; 4. PR interval: 0.12–0.20 s and constant; 5. QRS duration: below 0.12 s. Only after the five steps name the rhythm. Normal sinus rhythm passes all five: 60–100/min, regular, upright P before every QRS, PR 0.12–0.20 s, QRS below 0.12 s.
Five steps
1. Rate: 7 QRS complexes in 6 s, × 10 = 70 per minute.
2. Rhythm: irregularly irregular, R–R from 0.70 to 0.96 s with no pattern.
3. P waves: none; the baseline shows small irregular fibrillatory waves.
4. PR interval: not measurable.
5. QRS: 0.06 s, narrow (below 0.12 s).
First abnormal step
rhythm → atrial fibrillation
Answer
rhythm
15.Prioritization & delegation
Answer: D · “I will come and check the pump and the IV site now.”
Why this is the answer
An alarm may mean an occlusion, air in the line or infiltration. The nurse checks the pump and site; the assistant should not adjust the pump or silence alarms.
Answer
D · “I will come and check the pump and the IV site now.”
16.Prioritization & delegation
Answer: D · 6 hours after carotid endarterectomy: neck swelling increasing, says it is hard to swallow
Why this is the answer
Growing neck swelling after carotid surgery suggests a hematoma that can compress the airway. A pink, moist stoma and light pink urine with irrigation are expected, and moderate pain with movement is common.
Answer
D · 6 hours after carotid endarterectomy: neck swelling increasing, says it is hard to swallow