Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient's blood pressure is 120/60 mmHg. What is the approximate mean arterial pressure?
A80 mmHg
B100 mmHg
C60 mmHg
D90 mmHg
2.Med-surg: cardiovascular & respiratoryHard
A patient taking dabigatran has a serious gastrointestinal bleed. Which specific reversal agent may be used?
AIdarucizumab
BProtamine sulfate
CTranexamic acid alone
DPhytomenadione (vitamin K)
3.Med-surg: neuro, endocrine & renalMedium
A patient taking sodium valproate becomes tired and is vomiting, and the nurse notices yellowing of the eyes. What is the main concern?
ADehydration from drinking too little
BA sign that the dose is too low
CA normal adjustment reaction to the drug
DLiver toxicity from valproate
4.Med-surg: neuro, endocrine & renalHard
A patient who had pituitary surgery has fatigue and feels cold. TSH is low, and free T4 is low. What is the most likely cause?
AHyperthyroidism from Graves' disease
BPrimary hypothyroidism from thyroid failure
CSecondary hypothyroidism
DOver-replacement with levothyroxine
5.Med-surg: GI, perioperative & oncologyMedium
What is the main clinical difference between small and large bowel obstruction?
AThere is no clinical difference; only a CT scan can tell them apart
BSmall bowel: early vomiting, less distension; large bowel: later vomiting, marked distension
CSmall bowel: no vomiting at all; large bowel: early profuse vomiting with no distension
DSmall bowel: marked distension only; large bowel: no pain, no vomiting and no distension at all
6.Med-surg: GI, perioperative & oncologyHard
An 80-year-old has a fluid balance 3 L positive two days after surgery. They are now breathless, with crackles at both lung bases and swollen ankles. What should the nurse do?
AStop the IV fluids, sit the patient up and escalate
BIncrease the IV fluid rate to improve kidney flow
CEncourage the patient to drink more fluids
DLie the patient flat with the legs raised
7.Clinical nursingMedium
What should a nurse do during a generalised tonic-clonic seizure?
AHold the limbs firmly to stop the jerking and prevent injury
BGive the patient a drink of water
CProtect the head, time the seizure and do not put anything in the mouth
DPut a tongue depressor between the teeth so that the tongue is not bitten
8.Clinical nursingHard
A patient with a burn of 30% body surface area is admitted. Which early complication is of greatest concern in the first 24 hours?
AScarring and contractures
BPressure ulcers from prolonged immobility
CHypovolaemic shock from fluid loss
DConstipation
9.Lab values & electrolytesMedium
A patient with hyperkalemia received IV regular insulin with dextrose. Which result must the nurse monitor closely over the next hours?
ASerum calcium, because it falls sharply
BBlood glucose, because hypoglycemia can occur
CHemoglobin, because insulin causes red cell loss
DSerum sodium, because it rises quickly
10.Lab values & electrolytesHard
A patient on lithium has had vomiting and diarrhea for 3 days and has been taking ibuprofen. They now have a coarse tremor and confusion. The lithium level is 2.2 mEq/L. What is the best interpretation and action?
AA low level; ask for the lithium dose to be raised
BIbuprofen side effects only; give it with food
CA normal level; continue lithium as prescribed
DLithium toxicity; hold lithium and report urgently
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 148 mmol/L, glucose 13.6 mmol/L and urea 22.8 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 148 mmol/Lglucose 13.6 mmol/Lurea 22.8 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.09, PaCO₂ 41 mmHg (5.5 kPa), HCO₃⁻ 12 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.09PaCO₂ 41 mmHg (5.5 kPa)HCO₃⁻ 12 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This patient has a pacemaker. Interpret the lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1ventricular paced rhythm
2sinus rhythm with wide QRS
3paced rhythm, failure to capture
4idioventricular rhythm
15.Prioritization & delegationMedium
An arterial blood gas shows pH 7.28, PaCO₂ 40 mmHg (5.3 kPa) and HCO₃⁻ 16 mEq/L (mmol/L). How should the nurse interpret it?
AMetabolic alkalosis
BMetabolic acidosis
CRespiratory alkalosis
DRespiratory acidosis
16.Prioritization & delegationHard
A patient admitted with a stroke this morning asks for a glass of water. What should the nurse do first?
AGive thickened fluids without checking the swallow
BGive the water through a straw so it goes down slowly
CAsk the family to help the patient drink while sitting upright in a chair at the bedside
DCheck that a swallow screen has been done before giving anything by mouth
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · 80 mmHg
Why this is the answer
MAP ≈ diastolic + (systolic − diastolic) ÷ 3 = 60 + 60 ÷ 3 = 80 mmHg. The heart spends longer in diastole, so MAP is closer to the diastolic value. A MAP of at least about 65 mmHg is a common target for organ perfusion.
Answer
A · 80 mmHg
2.Med-surg: cardiovascular & respiratory
Answer: A · Idarucizumab
Why this is the answer
Idarucizumab binds dabigatran and reverses its effect within minutes. Andexanet alfa (or prothrombin complex concentrate where it is not available) is used for factor Xa inhibitors. Protamine reverses heparin and vitamin K reverses warfarin. Tranexamic acid may support haemostasis but is not a reversal agent.
Answer
A · Idarucizumab
3.Med-surg: neuro, endocrine & renal
Answer: D · Liver toxicity from valproate
Why this is the answer
Valproate can cause serious liver injury, especially early in treatment. Jaundice, vomiting, lethargy or abdominal pain need urgent review and liver function tests. Pancreatitis is another rare but serious effect.
Answer
D · Liver toxicity from valproate
4.Med-surg: neuro, endocrine & renal
Answer: C · Secondary hypothyroidism
Why this is the answer
When the pituitary cannot make enough TSH, the thyroid is not stimulated, so both TSH and free T4 are low. In primary thyroid failure, TSH is high. In secondary hypothyroidism, free T4, not TSH, is used to guide the dose.
Answer
C · Secondary hypothyroidism
5.Med-surg: GI, perioperative & oncology
Answer: B · Small bowel: early vomiting, less distension; large bowel: later vomiting, marked distension
Why this is the answer
In proximal small bowel obstruction, vomiting is early and prominent and distension mild. In large bowel obstruction, distension is marked, constipation early and vomiting later (and may be faeculent). Imaging confirms the level and cause.
Answer
B · Small bowel: early vomiting, less distension; large bowel: later vomiting, marked distension
6.Med-surg: GI, perioperative & oncology
Answer: A · Stop the IV fluids, sit the patient up and escalate
Why this is the answer
Older patients and those with heart or kidney disease can develop fluid overload. The nurse stops fluids, sits the patient up, gives oxygen if needed and asks for medical review, often for diuretics.
Answer
A · Stop the IV fluids, sit the patient up and escalate
7.Clinical nursing
Answer: C · Protect the head, time the seizure and do not put anything in the mouth
Why this is the answer
Remove nearby hazards, cushion the head, note the time and do not restrain or put objects in the mouth. Once jerking stops, place the patient in the recovery position and check the airway.
Answer
C · Protect the head, time the seizure and do not put anything in the mouth
8.Clinical nursing
Answer: C · Hypovolaemic shock from fluid loss
Why this is the answer
Major burns cause fluid to shift out of the circulation, so formula-guided IV fluid resuscitation and urine output monitoring are key. Airway burns are another early danger.
Answer
C · Hypovolaemic shock from fluid loss
9.Lab values & electrolytes
Answer: B · Blood glucose, because hypoglycemia can occur
Why this is the answer
Insulin shifts potassium into cells but also lowers glucose, and hypoglycemia can occur hours later, especially in kidney failure. Glucose is checked frequently, and potassium is rechecked, as the effect lasts only a few hours.Checked against:High potassium level · MedlinePlus (NIH) (2025)
Answer
B · Blood glucose, because hypoglycemia can occur
10.Lab values & electrolytes
Answer: D · Lithium toxicity; hold lithium and report urgently
Why this is the answer
A level of 2.2 mEq/L with coarse tremor and confusion is lithium toxicity. Fluid loss and NSAIDs both reduce lithium excretion by the kidneys. The dose is held, the provider is informed at once, and fluids and close monitoring are expected; severe cases may need dialysis.
Answer
D · Lithium toxicity; hold lithium and report urgently
11.Arterial blood gas interpretation
Answer: Osm = 332 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·148 + 13.6 + 22.8 = 332.4 ≈ 332 mOsm/kg
Answer
Osm = 332 mOsm/kg
12.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·12 + 8 = 26 → 24–28 mmHg
Compare
measured: 41 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
13.ECG rhythm strip interpretation
Answer: QTc = 0.412 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 8.5 × 0.04 = 0.34 s
RR = 17 × 0.04 = 0.68 s
Bazett’s formula
QTc = 0.34/√0.68 = 0.34/0.8246 = 0.412 s
Answer
QTc = 0.412 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (412 ms)
14.ECG rhythm strip interpretation
Answer: ventricular paced rhythm
Paced rhythms: a pacemaker impulse shows as a narrow vertical pacing spike. After a ventricular spike the QRS is wide (0.12 s or more), because the impulse spreads from the lead through the muscle instead of the conduction system; with right-ventricular pacing it is often mostly negative in lead II. A spike before each P wave means atrial pacing, and a dual-chamber (AV) pacemaker shows an atrial spike and a P wave, then, after the programmed AV delay, a ventricular spike and a wide QRS. Capture means every spike is followed by a depolarisation. Failure to capture is a spike without a P wave or QRS after it; failure to sense (spikes that ignore the patient’s own beats) and failure to pace (no spike when one is due) are the other classic malfunctions.
Five steps
1. Rate: R–R = 20 small boxes, 1500 ÷ 20 ≈ 75 per minute.
2. Rhythm: regular, every R–R is 0.80 s.
3. P waves: none visible; a sharp pacing spike comes just before every QRS.
4. PR interval: not measurable.
5. QRS: 0.16 s, wide, and every spike is followed by a QRS (capture).
Interpretation
ventricular paced rhythm
Answer
ventricular paced rhythm
The paced QRS is wide by nature; do not call it a bundle branch block or a ventricular rhythm.
15.Prioritization & delegation
Answer: B · Metabolic acidosis
Why this is the answer
The pH is low (acidosis), the PaCO₂ is normal and the bicarbonate is low, so the cause is metabolic. Causes include diabetic ketoacidosis, sepsis and kidney failure.
Answer
B · Metabolic acidosis
16.Prioritization & delegation
Answer: D · Check that a swallow screen has been done before giving anything by mouth
Why this is the answer
After a stroke, the patient stays NPO (nothing by mouth) until a swallow screen shows it is safe. Giving fluids first risks aspiration, even with a straw or thickener.
Answer
D · Check that a swallow screen has been done before giving anything by mouth