Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Why is a non-selective beta-blocker such as propranolol usually avoided in a patient with asthma?
AIt raises the heart rate sharply during an acute asthma attack
BIt can cause bronchospasm by blocking beta-2 receptors
CIt makes inhaled corticosteroids work too strongly
DIt thickens airway mucus by drying the airways
2.Med-surg: cardiovascular & respiratoryHard
A frightened young woman is breathing fast and has tingling fingers. Her blood gas shows pH 7.50 and a low PaCO₂. SpO₂ is 99% on air. What does this show?
AMetabolic acidosis from kidney failure
BRespiratory acidosis from hypoventilation
CMetabolic alkalosis from vomiting
DRespiratory alkalosis from hyperventilation
3.Med-surg: neuro, endocrine & renalMedium
Why is once-daily prednisolone usually taken in the morning with food?
ATo match the natural cortisol rhythm and protect the stomach
BBecause food doubles the strength of the dose
CBecause it cannot be absorbed at night
DBecause it causes drowsiness and is safer to take during the day
4.Med-surg: neuro, endocrine & renalHard
A patient in a halo vest for a cervical spine fracture has a cardiac arrest. What must be immediately available?
AA hard board to slide under the vest
BThe tool to open the front of the vest for CPR
CScissors to cut through the skull pins
DA pillow to raise the head and shoulders
5.Med-surg: GI, perioperative & oncologyMedium
A patient has taken oral prednisolone daily for many months. Why is this important before surgery?
ASteroids make the anaesthetic drugs last much longer
BThey may need extra steroid cover to prevent an adrenal crisis
CSteroids must always be stopped a full week before any type of surgery
DSteroids prevent all wound infections after surgery
6.Med-surg: GI, perioperative & oncologyHard
During preoperative assessment, a patient says their brother had a "very high fever" during an anaesthetic. What is the most important action?
AGive paracetamol before surgery to prevent fever
BReassure the patient that fevers after anaesthesia are always harmless
CInform the anaesthetist, as malignant hyperthermia may run in the family
DRecord it as a family allergy to paracetamol
7.Clinical nursingMedium
Which type of painkiller should a patient with liver cirrhosis usually avoid?
ANon-steroidal anti-inflammatory drugs such as ibuprofen
BHot packs applied to a painful joint
CLocal anaesthetic creams
DParacetamol (acetaminophen), given in a carefully reduced and monitored dose
8.Clinical nursingHard
Which set of findings best distinguishes cardiogenic shock from hypovolaemic shock?
ATachycardia, hypotension and a weak, thready peripheral pulse
BCool, pale skin
CRaised jugular venous pressure and lung crackles
DReduced urine output
9.Lab values & electrolytesMedium
A patient with suspected pulmonary TB needs sputum samples for acid-fast bacilli. Which instruction is correct?
AGive several deep-cough samples, often first thing in the morning
BGive several samples of nasal mucus blown into a tissue
CGive one sample of saliva collected from the mouth at any time of day
DGive one sample after brushing with mouthwash so it is clean
10.Lab values & electrolytesHard
A patient has fatigue, weight gain and constipation. Results: TSH 24 mIU/L, free T4 low, total cholesterol 285 mg/dL (7.4 mmol/L), sodium 131 mEq/L. What is the best interpretation?
APrimary hypothyroidism, which can raise lipids and lower sodium
BFamilial hypercholesterolemia, unrelated to the thyroid results
CHyperthyroidism, with suppressed thyroid hormone production
DSecondary hypothyroidism from failure of the pituitary gland
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.43, PaCO₂ 47 mmHg (6.3 kPa) and HCO₃⁻ 30 mmol/L. The primary disorder is metabolic alkalosis. How far is it compensated? Click your answer.
pH 7.43PaCO₂ 47 mmHg (6.3 kPa)HCO₃⁻ 30 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.19, PaCO₂ 19 mmHg (2.5 kPa), HCO₃⁻ 7 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.19PaCO₂ 19 mmHg (2.5 kPa)HCO₃⁻ 7 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
This lead II strip shows sinus rhythm with one pause. Measure the pause, the R–R interval across it, in seconds.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
pause = s
14.ECG rhythm strip interpretationHard
A monitored patient is found unresponsive and not breathing normally, and no carotid pulse can be felt. The monitor shows this organised rhythm. What is this situation called? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1ventricular fibrillation
2asystole
3pulseless electrical activity (PEA)
4sinus bradycardia
15.Prioritization & delegationMedium
A nurse teaches a patient about sublingual nitroglycerin tablets. Which statement shows a need for further teaching?
A“I will sit down before I take a tablet.”
B“I will swallow the tablet with a glass of water.”
C“I may get a headache after taking a tablet.”
D“I will keep the tablets in their original dark container.”
16.Prioritization & delegationHard
A patient has a chest drain for a pneumothorax. The nurse sees constant bubbling in the water-seal chamber. What does this most likely mean?
AAn air leak in the patient or the system that needs checking
BThe drain is working normally and no action is needed
CThe suction is set too low and needs to be turned up
DThe lung has fully re-expanded, so the drain is ready to come out
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · It can cause bronchospasm by blocking beta-2 receptors
Why this is the answer
Beta-2 receptors in the airways mediate bronchodilation. Blocking them can trigger severe bronchospasm in asthma and also blunts the effect of salbutamol. Cardioselective beta-1 blockers are safer but still used with caution.
Answer
B · It can cause bronchospasm by blocking beta-2 receptors
2.Med-surg: cardiovascular & respiratory
Answer: D · Respiratory alkalosis from hyperventilation
Why this is the answer
Hyperventilation blows off CO₂, causing respiratory alkalosis. The alkalosis lowers ionised calcium, causing tingling and carpopedal spasm. Normal oxygen saturation is reassuring, but organic causes such as PE, asthma or diabetic ketoacidosis must still be excluded.
Answer
D · Respiratory alkalosis from hyperventilation
3.Med-surg: neuro, endocrine & renal
Answer: A · To match the natural cortisol rhythm and protect the stomach
Why this is the answer
Morning dosing mimics the normal early-morning cortisol peak, causes less adrenal suppression and less sleep disturbance. Taking it with food reduces gastric irritation.
Answer
A · To match the natural cortisol rhythm and protect the stomach
4.Med-surg: neuro, endocrine & renal
Answer: B · The tool to open the front of the vest for CPR
Why this is the answer
The tool to release the anterior vest is kept attached to the vest so it can be opened quickly for CPR or airway management. Pin sites need regular care to prevent infection, and the patient needs teaching about skin care under the vest.
Answer
B · The tool to open the front of the vest for CPR
5.Med-surg: GI, perioperative & oncology
Answer: B · They may need extra steroid cover to prevent an adrenal crisis
Why this is the answer
Long-term steroids suppress the adrenal glands, so they cannot raise cortisol in response to surgical stress. Extra steroid cover may be prescribed, and steroids are not stopped suddenly. Healing may also be slower.
Answer
B · They may need extra steroid cover to prevent an adrenal crisis
6.Med-surg: GI, perioperative & oncology
Answer: C · Inform the anaesthetist, as malignant hyperthermia may run in the family
Why this is the answer
Malignant hyperthermia susceptibility is inherited. The anaesthetist plans a trigger-free anaesthetic, avoiding volatile agents and suxamethonium, and the family may be referred for testing.
Answer
C · Inform the anaesthetist, as malignant hyperthermia may run in the family
7.Clinical nursing
Answer: A · Non-steroidal anti-inflammatory drugs such as ibuprofen
Why this is the answer
NSAIDs increase the risk of GI bleeding and can trigger kidney failure and fluid retention in cirrhosis. Paracetamol is usually preferred at a lower, carefully chosen dose.
Answer
A · Non-steroidal anti-inflammatory drugs such as ibuprofen
8.Clinical nursing
Answer: C · Raised jugular venous pressure and lung crackles
Why this is the answer
Both types cause tachycardia, hypotension, cool skin and low urine output. In cardiogenic shock the failing heart causes venous congestion and pulmonary oedema, so large fluid boluses may worsen it.
Answer
C · Raised jugular venous pressure and lung crackles
9.Lab values & electrolytes
Answer: A · Give several deep-cough samples, often first thing in the morning
Why this is the answer
Usually a series of three sputum samples is collected, at least one in the early morning, when secretions have pooled overnight. The patient rinses with water (not mouthwash), takes deep breaths and coughs deeply to bring up sputum, not saliva. Airborne precautions are used.Checked against:Sputum Culture · MedlinePlus (NIH) (2024); Acid-Fast Bacillus (AFB) Tests · MedlinePlus (NIH) (2025)
Answer
A · Give several deep-cough samples, often first thing in the morning
10.Lab values & electrolytes
Answer: A · Primary hypothyroidism, which can raise lipids and lower sodium
A · Primary hypothyroidism, which can raise lipids and lower sodium
11.Arterial blood gas interpretation
Answer: fully compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.43: within 7.35–7.45
PaCO₂ 47 mmHg: high (35–45)
HCO₃⁻ 30 mmol/L: high (22–26)
Compensation
Clinically, also check the expected compensation: for a metabolic alkalosis PaCO₂ ≈ 0.7·HCO₃⁻ + 21 = 40–44 mmHg, so the measured 47 mmHg points to an additional respiratory acidosis (a mixed disorder). The answer above is the ROME exam classification.
fully compensated
Answer
fully compensated
12.Arterial blood gas interpretation
Answer: appropriate compensation
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·7 + 8 = 18.5 → 16.5–20.5 mmHg
Compare
measured: 19 mmHg → appropriate compensation
Answer
appropriate compensation
13.ECG rhythm strip interpretation
Answer: pause = 1.52 s
Narrow-complex tachycardia and pauses: supraventricular tachycardia (SVT) is a regular tachycardia at about 150–250/min with narrow QRS complexes; the P waves are usually not visible because they are hidden in the QRS complex or the T wave. Sinus tachycardia in an adult at rest is usually below about 150/min and has a visible P wave before every QRS; atrial flutter with 2:1 conduction often runs at about 150/min and shows sawtooth waves. In sinus arrest the sinus node stops firing for a moment: a pause with no P wave and no QRS whose length is not a whole number of P–P cycles (a pause of exactly two or three cycles points to sinus exit block instead).
Measure
38 small boxes from R to R across the pause
Convert
pause = 38 × 0.04 s = 1.52 s
Compare with P–P
1.52 ÷ 0.92 ≈ 1.7 P–P cycles, not a whole number
Answer
pause = 1.52 s
No P wave appears in the pause, and the pause is not a whole number of P–P cycles: sinus arrest. A pause of exactly two or three cycles would point to sinus exit block.
14.ECG rhythm strip interpretation
Answer: pulseless electrical activity (PEA)
Pulseless electrical activity (PEA): PEA cannot be seen on a strip. The monitor shows organised electrical activity (a rhythm other than VF, VT or asystole) but the patient has no palpable pulse, so it is recognised by checking the patient. In adult resuscitation guidelines PEA and asystole are the non-shockable cardiac arrest rhythms: high-quality CPR, epinephrine as soon as possible and a search for reversible causes (the Hs and Ts, such as hypovolaemia, hypoxia, tension pneumothorax and cardiac tamponade). VF and pulseless VT are the shockable rhythms.
What the strip shows
1. Rate: R–R = 28 small boxes, 1500 ÷ 28 ≈ 54 per minute.
2. Rhythm: regular, every R–R is 1.12 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.16 s, constant, within 0.12–0.20 s.
5. QRS: 0.08 s, narrow (below 0.12 s).
sinus bradycardia
What the patient shows
no pulse despite organised electrical activity: pulseless electrical activity (PEA), a non-shockable cardiac arrest rhythm
Answer
pulseless electrical activity (PEA)
Answer
pulseless electrical activity (PEA)
PEA is recognised at the bedside, never from the strip alone. This is exam practice, not clinical guidance.
15.Prioritization & delegation
Answer: B · “I will swallow the tablet with a glass of water.”
Why this is the answer
Sublingual tablets dissolve under the tongue and are absorbed quickly there. Sitting down reduces falls from low blood pressure, the tablets are protected from light and moisture, and headache is a common side effect.
Answer
B · “I will swallow the tablet with a glass of water.”
16.Prioritization & delegation
Answer: A · An air leak in the patient or the system that needs checking
Why this is the answer
Continuous bubbling in the water-seal chamber signals an air leak. The nurse checks the connections from the patient to the drain and reports a leak that cannot be fixed.
Answer
A · An air leak in the patient or the system that needs checking