Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size E oxygen cylinder (factor 0.28 L/psi) reads 2100 psi and runs at 10 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
2100 psif = 0.28 L/psi10 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A cylinder with a water capacity of 3 L is filled to 99 bar and runs at 4 L/min. The gas volume is about the water capacity × the pressure. In this exercise the cylinder is changed at 20 bar. How many minutes t until it must be changed? Round down to a whole minute.
3 L99 bar4 L/min20 bar
t = min
3.Arterial blood gas interpretationMedium
Practice values: Na⁺ 142 mmol/L, glucose 18.4 mmol/L and urea 20.6 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 142 mmol/Lglucose 18.4 mmol/Lurea 20.6 mmol/L
Osm = mOsm/kg
4.Arterial blood gas interpretationHard
Practice values: Na⁺ 146, Cl⁻ 115, HCO₃⁻ 22 mmol/L and albumin 17 g/L. Find the albumin-corrected anion gap AGc = AG + 0.25·(40 − albumin).
Practice exercise (made-up values, not clinical guidance). A practice patient after a head injury opens the eyes spontaneously, is oriented to person, place and time and shows as the best motor response: obeys commands. Work out the GCS and classify the head injury by it. Click your answer.
1mild
2moderate
3severe
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). At 1 minute after birth, a practice newborn has pink skin all over, a heart rate of 170/min, a cry, cough or sneeze when stimulated, active movement and slow, irregular breathing with a weak cry. Score the APGAR and click how the score is interpreted.
1reassuring
2moderately abnormal
3low
7.Med-surg: cardiovascular & respiratoryMedium
Which statement about a spacer for a metered-dose inhaler is correct?
ALess coordination is needed, and more drug reaches the lungs
BIt means the steroid preventer inhaler can be stopped altogether
CIt is designed to be used with dry-powder inhalers
DIt makes each puff of the drug stronger than usual
8.Med-surg: cardiovascular & respiratoryHard
A patient's chest drain tubing disconnects from the drainage unit. What should the nurse do first?
ARemove the drain from the chest and cover the site
BLeave it open to air until the doctor arrives to review it
CClamp the tube for several hours and recheck the patient later
DReconnect it, or put the tube end in sterile water, then assess
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 53 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(2100 − 200)·0.28 = 532 L
Duration
532/10 = 53.2 min → t = 53 min
Answer
t = 53 min
2.Oxygen therapy & respiratory calculations
Answer: t = 59 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable gas
3·(99 − 20) = 237 L
Duration
237/4 = 59.25 min → t = 59 min
Answer
t = 59 min
3.Arterial blood gas interpretation
Answer: Osm = 323 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·142 + 18.4 + 20.6 = 323 ≈ 323 mOsm/kg
Answer
Osm = 323 mOsm/kg
4.Arterial blood gas interpretation
Answer: AGc = 14.75 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 146 − (115 + 22) = 9
Correction for albumin
9 + 0.25·(40 − 17) = 14.75 mmol/L
Answer
AGc = 14.75 mmol/L
Above about 12 after correction: a high anion gap.
5.Clinical assessment scores
Answer: mild
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Score each area
E: opens the eyes spontaneously → 4
V: is oriented to person, place and time → 5
M: obeys commands → 6
Add
GCS = 4 + 5 + 6 = 15
Severity
GCS 15 → mild
Answer
mild
6.Clinical assessment scores
Answer: reassuring
APGAR score: five signs, each scored 0, 1 or 2, checked at 1 and 5 minutes after birth. Appearance (colour): blue or pale 0, pink body with blue extremities 1, pink all over 2. Pulse: absent 0, below 100/min 1, 100/min or more 2. Grimace (reflex irritability): none 0, grimace 1, cry, cough or sneeze 2. Activity (tone): limp 0, some flexion 1, active movement 2. Respiration: absent 0, slow or irregular with a weak cry 1, good with a strong cry 2. A total of 7–10 is reassuring, 4–6 moderately abnormal and 0–3 low.
Score each sign
Appearance: pink skin all over → 2
Pulse: 170/min → 2
Grimace: a cry, cough or sneeze when stimulated → 2
Activity: active movement → 2
Respiration: slow, irregular breathing with a weak cry → 1
Add
APGAR = 2 + 2 + 2 + 2 + 1 = 9
Interpretation
9 → reassuring
Answer
reassuring
7.Med-surg: cardiovascular & respiratory
Answer: A · Less coordination is needed, and more drug reaches the lungs
Why this is the answer
A spacer slows the aerosol and holds it so the patient can inhale it with slow breaths. More drug reaches the lungs and less is deposited in the mouth. It is used with pressurised metered-dose inhalers, not dry-powder devices.
Answer
A · Less coordination is needed, and more drug reaches the lungs
8.Med-surg: cardiovascular & respiratory
Answer: D · Reconnect it, or put the tube end in sterile water, then assess
Why this is the answer
A disconnected tube lets atmospheric air enter the pleural space. Reconnecting quickly, or submerging the tube end 2–3 cm in sterile water as a temporary seal, restores the one-way valve. Then assess for respiratory distress and inform the team. Prolonged clamping risks tension pneumothorax.
Answer
D · Reconnect it, or put the tube end in sterile water, then assess