Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size H oxygen cylinder (factor 3.14 L/psi) reads 800 psi and runs at 5 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
800 psif = 3.14 L/psi5 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A ventilated woman is 163 cm tall and weighs 72 kg. Lung-protective ventilation is set at 4 mL per kg of predicted body weight. Using PBW = 45.5 + 0.91 × (height cm − 152.4) kg, find the tidal volume VT to the nearest mL.
163 cm72 kg4 mL/kg
VT = mL
3.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 8 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 8 mmol/L
PaCO₂ = mmHg
4.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 35% oxygen shows PaO₂ 92 mmHg (12.3 kPa) and PaCO₂ 47 mmHg (6.3 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Braden scale: sensory perception: very limited; moisture: very moist; activity: chairfast; mobility: completely immobile; nutrition: adequate; friction and shear: problem. Find the Braden total B.
6–23
B =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 28/min, SpO₂ 91% on room air, blood pressure 124/74 mmHg, pulse 120/min, alert, temperature 34.8 °C. Which clinical risk group does the patient fall into? Click it.
RR 28SpO₂ 91%airSBP 124HR 120AT 34.8 °C
1low
2low–medium
3medium
4high
7.Med-surg: cardiovascular & respiratoryMedium
A patient with angle-closure glaucoma needs nebulised ipratropium. What precaution is sensible?
AUse a mouthpiece or protect the eyes from the mist
BGive it only with the patient lying completely flat
CRun it at the highest possible gas flow
DMix it with an eye drop before putting it in the nebuliser
8.Med-surg: cardiovascular & respiratoryHard
After intubation, breath sounds are heard on the right side of the chest but not the left. What is the most likely cause?
AThe left lung has completely filled with fluid
BThe tube has entered the right main bronchus
CThe tube cuff has burst during insertion
DThe tube has entered the oesophagus
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 376 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(800 − 200)·3.14 = 1884 L
Duration
1884/5 = 376.8 min → t = 376 min
Answer
t = 376 min
That is about 6 h 16 min.
2.Oxygen therapy & respiratory calculations
Answer: VT = 221 mL
Ventilation: minute ventilation V̇E = tidal volume × respiratory rate (normal adult about 5–8 L/min). Alveolar ventilation V̇A = (tidal volume − dead space) × rate, because the air in the airways (about 150 mL in an adult) takes no part in gas exchange. Lung-protective ventilation uses about 6 mL per kg of predicted body weight (PBW): men 50 + 0.91 × (height in cm − 152.4) kg, women 45.5 + 0.91 × (height in cm − 152.4) kg (with inches: 2.3 per inch above 60 in).
Predicted body weight
PBW = 45.5 + 0.91·(163 − 152.4) = 55.15 kg
Tidal volume
VT = 4·55.15 = 220.6 ≈ 221 mL
Answer
VT = 221 mL
3.Arterial blood gas interpretation
Answer: PaCO₂ = 20 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·8 + 8 = 20 mmHg
range: 18–22 mmHg
Answer
PaCO₂ = 20 mmHg
4.Arterial blood gas interpretation
Answer: A–a gradient = 98.8 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Braden scale: six subscales for pressure-injury risk. Sensory perception, moisture, activity, mobility and nutrition score 1 to 4, from the worst level (1) to no problem (4); friction and shear scores 1 to 3. The total runs from 6 to 23, and a lower total means a higher risk. Common bands: 19–23 not at risk, 15–18 mild risk, 13–14 moderate risk, 10–12 high risk and 9 or below very high risk.
Score each subscale
sensory perception: very limited → 2
moisture: very moist → 2
activity: chairfast → 2
mobility: completely immobile → 1
nutrition: adequate → 3
friction and shear: problem → 1
Add
Braden total = 2 + 2 + 2 + 1 + 3 + 1 = 11
Answer
B = 11
6.Clinical assessment scores
Answer: high
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 28/min → 3
SpO₂ 91% → 3
on air → 0
SBP 124 mmHg → 0
HR 120/min → 2
alert (A) → 0
T 34.8 °C → 3
Total and red scores
NEWS2 = 3 + 3 + 0 + 0 + 2 + 0 + 3 = 11
At least one parameter scores 3.
Risk group
high
Answer
high
A total of 5 or more calls for an urgent clinical response.
7.Med-surg: cardiovascular & respiratory
Answer: A · Use a mouthpiece or protect the eyes from the mist
Why this is the answer
Ipratropium is an antimuscarinic bronchodilator. Mist escaping from a face mask can reach the eyes, dilate the pupil and trigger acute angle-closure glaucoma in susceptible patients. A mouthpiece or eye protection reduces the risk.
Answer
A · Use a mouthpiece or protect the eyes from the mist
8.Med-surg: cardiovascular & respiratory
Answer: B · The tube has entered the right main bronchus
Why this is the answer
The right main bronchus is more in line with the trachea, so a tube pushed too far usually enters it and only the right lung is ventilated. The tube is withdrawn slightly by the team and position is rechecked. Oesophageal intubation gives no breath sounds and gastric gurgling.