Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A patient has Hb 154 g/L, SaO₂ 95% and PaO₂ 74 mmHg (9.9 kPa). Find the arterial oxygen content CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg) in mL O₂/dL.
Hb 154 g/LSaO₂ 95%PaO₂ 74 mmHg (9.9 kPa)
CaO₂ = mL/dL
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient with acute hypoxaemia and bilateral opacities, not explained by heart failure, has PaO₂ 10.7 kPa on 45% oxygen with a PEEP of 5 cmH₂O. Grade the ARDS severity with the Berlin definition. Click your answer.
PaO₂ 10.7 kPaFiO₂ 45%PEEP 5 cmH₂O
1above 300
2mild
3moderate
4severe
5not gradable: PEEP below 5
3.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.27, PaCO₂ 18 mmHg (2.4 kPa) and HCO₃⁻ 8 mmol/L. The primary disorder is metabolic acidosis. How far is it compensated? Click your answer.
pH 7.27PaCO₂ 18 mmHg (2.4 kPa)HCO₃⁻ 8 mmol/L
1uncompensated
2partially compensated
3fully compensated
4.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.08, PaCO₂ 42 mmHg (5.6 kPa), HCO₃⁻ 12 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.08PaCO₂ 42 mmHg (5.6 kPa)HCO₃⁻ 12 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Braden scale: sensory perception: slightly limited; moisture: constantly moist; activity: chairfast; mobility: no limitation; nutrition: adequate; friction and shear: potential problem. Find the Braden total B.
6–23
B =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Braden scale: sensory perception: completely limited; moisture: rarely moist; activity: chairfast; mobility: very limited; nutrition: adequate; friction and shear: problem. Use the bands 19–23 not at risk, 15–18 mild, 13–14 moderate, 10–12 high and 9 or below very high. Click the risk level.
1not at risk
2mild risk
3moderate risk
4high risk
5very high risk
7.Med-surg: cardiovascular & respiratoryMedium
After an acute coronary syndrome, a patient with a normal cholesterol level is prescribed a high-intensity statin. Why?
AStatins are given after an ACS mainly to lower the blood pressure
BStatins work as painkillers for chest pain
CStatins reduce further events whatever the starting cholesterol
DStatins are needed only if the cholesterol level is very high
8.Med-surg: cardiovascular & respiratoryHard
During a cardiac arrest, the monitor shows an organised rhythm, but there is no pulse. What should the team do?
AContinue CPR and give adrenaline (epinephrine), as the rhythm is non-shockable
BStop CPR, because an organised rhythm on the monitor means recovery
CGive adenosine to slow the rhythm down
DDeliver an unsynchronised shock at once and then check the pulse
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: CaO₂ = 19.83 mL/dL
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Hb in g/dL
154 g/L = 15.4 g/dL
Bound oxygen
1.34·15.4·0.95 = 19.6 mL/dL
Dissolved oxygen
0.003·74 = 0.222 mL/dL
Oxygen content
CaO₂ = 19.6 + 0.222 = 19.83 mL/dL
Answer
CaO₂ = 19.83 mL/dL
2.Oxygen therapy & respiratory calculations
Answer: moderate
P/F ratio and ARDS (Berlin definition): P/F = PaO₂ (mmHg)/FiO₂ (as a fraction). With PEEP or CPAP of at least 5 cmH₂O, ARDS is graded mild for 200 < P/F ≤ 300, moderate for 100 < P/F ≤ 200 and severe for P/F ≤ 100 mmHg. The other Berlin criteria (onset within a week, bilateral opacities, not fully explained by heart failure) must also be met. PaO₂ in kPa × 7.5 gives mmHg. The ROX index (SpO₂/FiO₂)/respiratory rate is used to follow patients on high-flow nasal oxygen.
PEEP
PEEP 5 ≥ 5 cmH₂O
PaO₂ in mmHg
10.7·7.5 = 80.25 mmHg
P/F ratio
P/F = 80.25/0.45 = 178.3 mmHg
Berlin severity
moderate
Answer
moderate
3.Arterial blood gas interpretation
Answer: partially compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.27: acidaemia (below 7.35)
PaCO₂ 18 mmHg: low (35–45)
HCO₃⁻ 8 mmol/L: low (22–26)
Compensation
partially compensated
Answer
partially compensated
4.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·12 + 8 = 26 → 24–28 mmHg
Compare
measured: 42 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
5.Clinical assessment scores
Answer: B = 15
Braden scale: six subscales for pressure-injury risk. Sensory perception, moisture, activity, mobility and nutrition score 1 to 4, from the worst level (1) to no problem (4); friction and shear scores 1 to 3. The total runs from 6 to 23, and a lower total means a higher risk. Common bands: 19–23 not at risk, 15–18 mild risk, 13–14 moderate risk, 10–12 high risk and 9 or below very high risk.
Score each subscale
sensory perception: slightly limited → 3
moisture: constantly moist → 1
activity: chairfast → 2
mobility: no limitation → 4
nutrition: adequate → 3
friction and shear: potential problem → 2
Add
Braden total = 3 + 1 + 2 + 4 + 3 + 2 = 15
Answer
B = 15
6.Clinical assessment scores
Answer: moderate risk
Braden scale: six subscales for pressure-injury risk. Sensory perception, moisture, activity, mobility and nutrition score 1 to 4, from the worst level (1) to no problem (4); friction and shear scores 1 to 3. The total runs from 6 to 23, and a lower total means a higher risk. Common bands: 19–23 not at risk, 15–18 mild risk, 13–14 moderate risk, 10–12 high risk and 9 or below very high risk.
Score each subscale
sensory perception: completely limited → 1
moisture: rarely moist → 4
activity: chairfast → 2
mobility: very limited → 2
nutrition: adequate → 3
friction and shear: problem → 1
Add
Braden total = 1 + 4 + 2 + 2 + 3 + 1 = 13
Risk level
13 → moderate risk
Answer
moderate risk
7.Med-surg: cardiovascular & respiratory
Answer: C · Statins reduce further events whatever the starting cholesterol
Why this is the answer
After ACS, high-intensity statin therapy reduces recurrent MI, stroke and death regardless of baseline cholesterol, partly by stabilising plaques. It is part of standard secondary prevention with antiplatelets, beta-blockers, ACE inhibitors and lifestyle change.
Answer
C · Statins reduce further events whatever the starting cholesterol
8.Med-surg: cardiovascular & respiratory
Answer: A · Continue CPR and give adrenaline (epinephrine), as the rhythm is non-shockable
Why this is the answer
Pulseless electrical activity is a non-shockable rhythm. Treatment is high-quality CPR, adrenaline as soon as possible and repeated, and a search for reversible causes (the 4 Hs and 4 Ts, such as hypoxia, hypovolaemia, tension pneumothorax and tamponade). Shocks are only for VF and pulseless VT.
Answer
A · Continue CPR and give adrenaline (epinephrine), as the rhythm is non-shockable