Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size H oxygen cylinder (factor 3.14 L/psi) reads 1250 psi and runs at 8 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
1250 psif = 3.14 L/psi8 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A transfer will take 60 minutes. The size E cylinder (factor 0.28 L/psi) reads 700 psi. Keeping a safe residual of 200 psi, what is the highest whole-number flow Q in L/min that lasts the whole transfer?
60 min700 psif = 0.28 L/psi200 psi
Q = L/min
3.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.44, PaCO₂ 23 mmHg (3.1 kPa) and HCO₃⁻ 15 mmol/L. The primary disorder is respiratory alkalosis. How far is it compensated? Click your answer.
pH 7.44PaCO₂ 23 mmHg (3.1 kPa)HCO₃⁻ 15 mmol/L
1uncompensated
2partially compensated
3fully compensated
4.Arterial blood gas interpretationHard
A practice gas shows a respiratory acidosis: pH 7.32, PaCO₂ 73 mmHg (9.7 kPa), HCO₃⁻ 36 mmol/L. Use the rules ‘HCO₃⁻ rises 1 mmol/L per 10 mmHg (acute) or 3.5 mmol/L per 10 mmHg (chronic)’ to classify it. Click your answer.
pH 7.32PaCO₂ 73 mmHg (9.7 kPa)HCO₃⁻ 36 mmol/L
1acute
2chronic
3acute on chronic
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Morse fall scale: history of falling in the last 3 months: yes; secondary diagnosis: no; ambulatory aid: none, bed rest or nurse assists; IV therapy or saline lock: yes; gait: normal, bed rest or wheelchair; mental status: overestimates or forgets limits. Find the Morse total MFS.
0–125
MFS =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). At 5 minutes after birth, a practice newborn has a pink body with blue hands and feet, a heart rate of 60/min, a grimace when stimulated, some flexion of the arms and legs and slow, irregular breathing with a weak cry. Score the APGAR and click how the score is interpreted.
1reassuring
2moderately abnormal
3low
7.Med-surg: cardiovascular & respiratoryMedium
How does ezetimibe lower cholesterol?
AIt reduces absorption of cholesterol from the gut
BIt blocks cholesterol production by enzymes in the liver
CIt dissolves plaques already in the arteries
DIt increases cholesterol loss in the urine
8.Med-surg: cardiovascular & respiratoryHard
The stump of a recent below-knee amputation suddenly bleeds heavily through the dressing. What should the nurse do first?
AEncourage the patient to walk on crutches to ease the pressure
BApply firm direct pressure and call for urgent surgical help
CApply a warm compress to the stump
DRemove all the dressings and wait for the bleeding to stop by itself
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 412 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(1250 − 200)·3.14 = 3297 L
Duration
3297/8 = 412.1 min → t = 412 min
Answer
t = 412 min
That is about 6 h 52 min.
2.Oxygen therapy & respiratory calculations
Answer: Q = 2 L/min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(700 − 200)·0.28 = 140 L
Highest flow
140/60 = 2.333 L/min → Q = 2 L/min
Answer
Q = 2 L/min
3.Arterial blood gas interpretation
Answer: fully compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.44: within 7.35–7.45
PaCO₂ 23 mmHg: low (35–45)
HCO₃⁻ 15 mmol/L: low (22–26)
Compensation
fully compensated
Answer
fully compensated
4.Arterial blood gas interpretation
Answer: chronic
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected HCO₃⁻
acute: 24 + 1·3.3 = 27.3 mmol/L
chronic: 24 + 3.5·3.3 = 35.55 mmol/L
Compare
measured: 36 mmol/L → chronic
Answer
chronic
5.Clinical assessment scores
Answer: MFS = 60
Morse fall scale: six items. History of falling: no 0, yes 25. Secondary diagnosis: no 0, yes 15. Ambulatory aid: none, bed rest or nurse assistance 0; crutches, cane or walker 15; holding on to furniture 30. IV therapy or saline lock: no 0, yes 20. Gait: normal, bed rest or wheelchair 0; weak 10; impaired 20. Mental status: knows own limits 0; overestimates or forgets limits 15. The total runs from 0 to 125. Risk cut-offs differ between hospitals; a common set is 0–24 low, 25–44 moderate and 45 or more high.
Score each item
history of falling in the last 3 months: yes → 25
secondary diagnosis: no → 0
ambulatory aid: none, bed rest or nurse assists → 0
IV therapy or saline lock: yes → 20
gait: normal, bed rest or wheelchair → 0
mental status: overestimates or forgets limits → 15
Add
Morse total = 25 + 0 + 0 + 20 + 0 + 15 = 60
Answer
MFS = 60
6.Clinical assessment scores
Answer: moderately abnormal
APGAR score: five signs, each scored 0, 1 or 2, checked at 1 and 5 minutes after birth. Appearance (colour): blue or pale 0, pink body with blue extremities 1, pink all over 2. Pulse: absent 0, below 100/min 1, 100/min or more 2. Grimace (reflex irritability): none 0, grimace 1, cry, cough or sneeze 2. Activity (tone): limp 0, some flexion 1, active movement 2. Respiration: absent 0, slow or irregular with a weak cry 1, good with a strong cry 2. A total of 7–10 is reassuring, 4–6 moderately abnormal and 0–3 low.
Score each sign
Appearance: a pink body with blue hands and feet → 1
Pulse: 60/min → 1
Grimace: a grimace when stimulated → 1
Activity: some flexion of the arms and legs → 1
Respiration: slow, irregular breathing with a weak cry → 1
Add
APGAR = 1 + 1 + 1 + 1 + 1 = 5
Interpretation
5 → moderately abnormal
Answer
moderately abnormal
Below 7 at 5 minutes, the score is usually repeated every 5 minutes up to 20 minutes.
7.Med-surg: cardiovascular & respiratory
Answer: A · It reduces absorption of cholesterol from the gut
Why this is the answer
Ezetimibe blocks the intestinal cholesterol transporter (NPC1L1), so less dietary and biliary cholesterol is absorbed and LDL falls. It is often added to a statin. Statins act by inhibiting HMG-CoA reductase in the liver.
Answer
A · It reduces absorption of cholesterol from the gut
8.Med-surg: cardiovascular & respiratory
Answer: B · Apply firm direct pressure and call for urgent surgical help
Why this is the answer
Haemorrhage from a stump needs immediate direct pressure, elevation if appropriate, and urgent surgical help. A tourniquet should be available as policy directs. Vital signs are monitored for shock.
Answer
B · Apply firm direct pressure and call for urgent surgical help