Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A ventilated patient who meets the other Berlin criteria for ARDS has PaO₂ 55 mmHg (7.3 kPa) on 100% oxygen with a PEEP of 8 cmH₂O. Calculate the P/F ratio and click the ARDS severity.
PaO₂ 55 mmHg (7.3 kPa)FiO₂ 100%PEEP 8 cmH₂O
1above 300: no ARDS grade
2mild
3moderate
4severe
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A transfer will take 75 minutes. The size E cylinder (factor 0.28 L/psi) reads 1750 psi. Keeping a safe residual of 200 psi, what is the highest whole-number flow Q in L/min that lasts the whole transfer?
75 min1750 psif = 0.28 L/psi200 psi
Q = L/min
3.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 69 mmHg (9.2 kPa). Use the rule that in acute respiratory acidosis HCO₃⁻ rises by 1 mmol/L for every 10 mmHg that PaCO₂ is above 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
A practice gas shows a metabolic acidosis: pH 7.22, PaCO₂ 43 mmHg (5.7 kPa), HCO₃⁻ 17 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.22PaCO₂ 43 mmHg (5.7 kPa)HCO₃⁻ 17 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice chart records GCS 13, with E4 and V4. What motor score M was recorded, and which response does it describe? Give the number.
GCS 13E4V4
M =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). An adult weighs 130 kg and is 184 cm tall. Calculate the BMI and click the WHO weight category.
130 kg184 cm
1underweight
2healthy weight
3overweight
4obesity class I
5obesity class II
6obesity class III
7.Med-surg: cardiovascular & respiratoryMedium
A patient in cardiac rehabilitation asks how hard to exercise. Which simple guide is commonly taught?
AExercise only until the heart rate rises even slightly
BExercise until chest pain starts, then stop
CExercise until they are too breathless to speak at all
DExercise so they are a little breathless but can still talk
8.Med-surg: cardiovascular & respiratoryHard
A patient is going home after a spontaneous pneumothorax treated with a chest drain. Which advice is correct?
AFly home as soon as possible so they can recover in comfort there
BExpect it never to happen again, so no follow-up is needed
CStop smoking and do not fly until a doctor confirms full resolution
DTake up scuba diving to strengthen the lungs
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: severe
P/F ratio and ARDS (Berlin definition): P/F = PaO₂ (mmHg)/FiO₂ (as a fraction). With PEEP or CPAP of at least 5 cmH₂O, ARDS is graded mild for 200 < P/F ≤ 300, moderate for 100 < P/F ≤ 200 and severe for P/F ≤ 100 mmHg. The other Berlin criteria (onset within a week, bilateral opacities, not fully explained by heart failure) must also be met. PaO₂ in kPa × 7.5 gives mmHg. The ROX index (SpO₂/FiO₂)/respiratory rate is used to follow patients on high-flow nasal oxygen.
P/F ratio
P/F = 55/1 = 55 mmHg
Berlin severity
severe
Answer
severe
2.Oxygen therapy & respiratory calculations
Answer: Q = 5 L/min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(1750 − 200)·0.28 = 434 L
Highest flow
434/75 = 5.787 L/min → Q = 5 L/min
Answer
Q = 5 L/min
3.Arterial blood gas interpretation
Answer: HCO₃⁻ = 26.9 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|69 − 40| = 29 mmHg → 2.9 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 + 1·2.9 = 26.9 mmol/L
Answer
HCO₃⁻ = 26.9 mmol/L
4.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·17 + 8 = 33.5 → 31.5–35.5 mmHg
Compare
measured: 43 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
5.Clinical assessment scores
Answer: M = 5
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Motor score
M = 13 − 4 − 4 = 5
M5: moves a hand to the site of pressure (localises)
Answer
M = 5
6.Clinical assessment scores
Answer: obesity class II
Body mass index: BMI = weight (kg)/height (m)², with the height converted to metres first. With pounds and inches, BMI = 703 × weight (lb)/height (in)². WHO adult categories: below 18.5 underweight, 18.5–24.9 healthy weight, 25.0–29.9 overweight, 30.0–34.9 obesity class I, 35.0–39.9 obesity class II and 40 or more obesity class III.
BMI
BMI = 130/1.84² = 38.4
Category
obesity class II
Answer
obesity class II
7.Med-surg: cardiovascular & respiratory
Answer: D · Exercise so they are a little breathless but can still talk
Why this is the answer
Moderate-intensity exercise makes the patient slightly breathless but able to hold a conversation. Programmes start gently and progress. Patients stop and seek help if they get chest pain, severe breathlessness or dizziness.
Answer
D · Exercise so they are a little breathless but can still talk
8.Med-surg: cardiovascular & respiratory
Answer: C · Stop smoking and do not fly until a doctor confirms full resolution
Why this is the answer
Patients should not fly until the pneumothorax has resolved on X-ray, often with an extra waiting period. Diving is usually avoided permanently unless definitive surgery has been done. Smoking increases recurrence, which is common, so patients learn to seek help for new breathlessness or chest pain.
Answer
C · Stop smoking and do not fly until a doctor confirms full resolution