1.やさしい
Which herbal product is commonly taken for sleep and can add to the effect of sedatives?
- APeppermint
- BGinger
- CValerian
- DCranberry
2.やさしい
薬物代謝の典型的な第 II 相(抱合)反応はどれですか?
- A加水分解
- B還元
- C酸化
- Dグルクロン酸抱合
3.やさしい
Fibrates such as fenofibrate mainly lower which blood lipid?
- ATriglycerides
- BHDL cholesterol
- CBile acids
- DLipoprotein(a) only
4.ふつう
Why is IV promethazine given with great caution?
- AIt is a strong opioid that causes addiction
- BIt causes immediate kidney failure
- CIt can cause severe tissue injury if it leaks or enters an artery
- DIt causes a severe rise in blood pressure when it is given intravenously
5.ふつう
Before starting a TNF-alpha inhibitor such as adalimumab, which test is required?
- AA bone density scan
- BAn echocardiogram in every patient
- CScreening for latent tuberculosis
- DA glucose tolerance test
6.ふつう
A patient must mix regular (soluble) insulin and NPH (isophane) insulin in one syringe. What is the correct order?
- ADraw them up in separate syringes, then mix them in a cup
- BShake both vials hard, then draw them up in any order
- CDraw up the cloudy NPH insulin first, then the clear regular insulin
- DDraw up the clear regular insulin first, then the cloudy NPH insulin
7.むずかしい
500 mg の静注で初期血漿濃度が 10 mg/L になりました。分布容積はいくつですか?
- A5000 L
- B5 L
- C50 L
- D500 L
8.むずかしい
A patient with severe liver cirrhosis takes oral propranolol, a drug with a high first-pass metabolism. What effect is expected?
- AThe first-pass effect increases, so the drug becomes inactive
- BLess drug is absorbed from the gut, so a higher dose is needed
- CMore drug reaches the circulation, so a lower dose may be needed
- DThe drug is excreted faster by the kidney, so it works for a shorter time
解答
- 1. C · Valerian
- 2. D · グルクロン酸抱合
- 3. A · Triglycerides
- 4. C · It can cause severe tissue injury if it leaks or enters an artery
- 5. C · Screening for latent tuberculosis
- 6. D · Draw up the clear regular insulin first, then the cloudy NPH insulin
- 7. C · 50 L
- 8. C · More drug reaches the circulation, so a lower dose may be needed
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