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Vardas: ____________________ Data: ____________
1.Lengvas
What is enzyme induction?
AA drug causes an allergic reaction to enzymes
BA drug is converted into an enzyme in the body
CA drug speeds up liver enzymes, so other drugs are broken down faster
DA drug blocks liver enzymes, so other drugs build up in the blood
2.Lengvas
Which drug is an antidote for methanol or ethylene glycol (antifreeze) poisoning?
AFomepizole
BFlumazenil
CAtropine
DNaloxone
3.Lengvas
Why is folinic acid (leucovorin) given after high-dose methotrexate?
ATo treat an allergic reaction to methotrexate
BTo make methotrexate act faster on the tumour
CTo protect normal cells from methotrexate toxicity
DTo prevent nausea and vomiting after the methotrexate
4.Vidutinis
Why are patients taking simvastatin often advised to avoid large amounts of grapefruit juice?
AGrapefruit blocks cholesterol absorption and causes low cholesterol
BGrapefruit speeds up simvastatin breakdown in the liver, so the drug stops working
CGrapefruit makes the tablet dissolve in the mouth
DGrapefruit inhibits CYP3A4 in the gut, raising simvastatin levels and myopathy risk
5.Vidutinis
A patient is starting lamotrigine. Which adverse effect should the patient report at once?
ASlight tiredness in the afternoon
BA brief change in taste
CAny new skin rash
DMild headache on the first day
6.Vidutinis
How can the absorption of oral iron be improved?
ATake it at the same time as an antacid to protect the stomach
BTake it with a glass of milk
CTake it with vitamin C, such as orange juice, on an empty stomach
DTake it with a cup of strong tea
7.Sunkus
A 19-year-old woman is starting isotretinoin for severe acne. Which requirement is most important?
AWeekly hearing tests and monthly eye examinations during treatment
BTaking the drug only at weekends
CA high-vitamin A diet to boost the effect
DReliable contraception and pregnancy tests, as it is highly teratogenic
8.Sunkus
Varfariną vartojantis pacientas pradeda rifampicino kursą. Koks tikėtinas poveikis?
AINR padidėja, nes varfarinas metabolizuojamas lėčiau
BJokio poveikio, nes rifampicinas neabsorbuojamas
CVarfarinas paverčiamas vitaminu K
DINR sumažėja, nes varfarinas metabolizuojamas greičiau
Atsakymai
1. C · A drug speeds up liver enzymes, so other drugs are broken down faster
2. A · Fomepizole
3. C · To protect normal cells from methotrexate toxicity
4. D · Grapefruit inhibits CYP3A4 in the gut, raising simvastatin levels and myopathy risk
5. C · Any new skin rash
6. C · Take it with vitamin C, such as orange juice, on an empty stomach
7. D · Reliable contraception and pregnancy tests, as it is highly teratogenic
8. D · INR sumažėja, nes varfarinas metabolizuojamas greičiau
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