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Naam: ____________________ Datum: ____________
1.Makkelijk
Varenicline helps people stop smoking because it:
ABlocks dopamine receptors in the brain completely
BIs a form of nicotine absorbed slowly through the skin
CMakes cigarettes taste bitter
DIs a nicotinic partial agonist that reduces craving and reward
2.Makkelijk
Oxytocin is used in obstetrics mainly to:
AStop preterm labour by relaxing the uterine muscle
BMature the fetal lungs before birth
CLower blood pressure in pre-eclampsia
DInduce or strengthen contractions and prevent postpartum bleeding
3.Makkelijk
Wat beschrijft de "biologische beschikbaarheid"?
AHoe sterk een middel aan zijn receptor bindt
BHet deel van een dosis dat in de circulatie aan plasma-eiwitten is gebonden
CHet deel van een dosis dat onveranderd de grote circulatie bereikt
DHoe snel een middel wordt uitgescheiden
4.Gemiddeld
How should oral potassium chloride tablets be taken?
ACrushed and dissolved under the tongue
BLying down straight after the dose
CWith food and plenty of water, swallowed whole if slow-release
DOn an empty stomach with only a small sip of water, then lie down
5.Gemiddeld
Sumatriptan is contraindicated in which patient?
AA patient with iron deficiency anaemia
BA patient with mild asthma
CA patient with coronary artery disease
DA patient with a recent ankle sprain
6.Gemiddeld
A patient with a fentanyl patch is given home-care advice. Which instruction is correct?
ACut the patch in half if the pain is mild
BThrow used patches loose into the household bin with the packaging
CApply each new patch over the same skin area
DAvoid heating pads, hot baths and saunas over or near the patch
7.Moeilijk
A patient with severe liver cirrhosis takes oral propranolol, a drug with a high first-pass metabolism. What effect is expected?
ALess drug is absorbed from the gut, so a higher dose is needed
BMore drug reaches the circulation, so a lower dose may be needed
CThe first-pass effect increases, so the drug becomes inactive
DThe drug is excreted faster by the kidney, so it works for a shorter time
8.Moeilijk
A patient who used heroin a few hours ago is given a first dose of buprenorphine and quickly develops severe withdrawal. Why?
ABuprenorphine causes an allergic reaction in heroin users
BBuprenorphine is a pure antagonist like naloxone with no agonist effect
CBuprenorphine is a high-affinity partial agonist that displaces heroin
DBuprenorphine has no effect at opioid receptors
Antwoordenblad
1. D · Is a nicotinic partial agonist that reduces craving and reward
2. D · Induce or strengthen contractions and prevent postpartum bleeding
3. C · Het deel van een dosis dat onveranderd de grote circulatie bereikt
4. C · With food and plenty of water, swallowed whole if slow-release
5. C · A patient with coronary artery disease
6. D · Avoid heating pads, hot baths and saunas over or near the patch
7. B · More drug reaches the circulation, so a lower dose may be needed
8. C · Buprenorphine is a high-affinity partial agonist that displaces heroin
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