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Naam: ____________________ Datum: ____________
1.Makkelijk
Welke toedieningsweg omzeilt het first-pass-effect in de lever?
AZetpil hoog in het rectum
BDrank via de mond
CTablet via de mond
DIntraveneus
2.Makkelijk
Zolpidem is mainly prescribed for:
ATreatment of Parkinson's disease
BLong-term treatment of depression
CPrevention of migraine
DShort-term treatment of insomnia
3.Makkelijk
How does tramadol relieve pain?
AWeak opioid agonism plus inhibiting the reuptake of serotonin and noradrenaline
BAntagonising NMDA receptors in the spinal cord and blocking sodium channels
CBlocking sodium channels in peripheral nerves
DBlocking COX enzymes in the periphery
4.Gemiddeld
100 mL of an antibiotic is to be given over 30 minutes using a giving set of 20 drops/mL. What is the drip rate?
AAbout 67 drops per minute
BAbout 33 drops per minute
CAbout 20 drops per minute
DAbout 100 drops per minute
5.Gemiddeld
Which statement about allopurinol is correct?
AIt works within an hour to relieve joint pain
BIt increases uric acid production to flush out crystals
CIt lowers uric acid over time and does not relieve the pain of an acute attack
DIt is taken only during an acute attack and stopped as soon as the pain settles
6.Gemiddeld
When should a patient take a once-daily proton pump inhibitor such as omeprazole?
AStraight after a large evening meal
BOnly when heartburn is severe
CWith a glass of milk at bedtime, when acid output is highest
DAbout 30–60 minutes before the first meal of the day
7.Moeilijk
Which strategy is most effective at preventing errors with IV insulin infusions?
AAn independent double check and a smart pump with a drug library
BWriting "U" for units on the order
CUsing insulin syringes to measure large IV volumes
DPreparing insulin infusions in advance and leaving them unlabelled
8.Moeilijk
A patient took a large paracetamol (acetaminophen) overdose 6 hours ago and feels well. Why is treatment still urgent?
AThe drug will cause kidney stones within a few hours
BThe patient is at risk of immediate respiratory arrest
CLiver damage appears 1–3 days later, and early treatment works best
DParacetamol overdose only causes harm if symptoms start in the first hour
Antwoordenblad
1. D · Intraveneus
2. D · Short-term treatment of insomnia
3. A · Weak opioid agonism plus inhibiting the reuptake of serotonin and noradrenaline
4. A · About 67 drops per minute
5. C · It lowers uric acid over time and does not relieve the pain of an acute attack
6. D · About 30–60 minutes before the first meal of the day
7. A · An independent double check and a smart pump with a drug library
8. C · Liver damage appears 1–3 days later, and early treatment works best
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