A woman at 9 weeks has hCG levels that are much higher than expected, a uterus large for dates, severe vomiting and dark brown spotting. Which condition should be suspected?
AA hydatidiform (molar) pregnancy
BAn ectopic pregnancy
CA missed miscarriage
DA threatened miscarriage
3.การคำนวณขนาดยาปานกลาง
ผู้ป่วยน้ำหนัก 27 kg มีพื้นที่ผิวร่างกาย 0.93 m² คำสั่งใช้ยาคือ 375 mg/m² จงหาขนาดยา D ใน mg
A molar pregnancy causes very high hCG, a uterus larger than dates, hyperemesis and bleeding. Ectopic and failing pregnancies usually have lower than expected hCG.
คำตอบ
A · A hydatidiform (molar) pregnancy
3.การคำนวณขนาดยา
คำตอบ: D = 348.8 mg
Body-surface-area dosing: many cytotoxic and some paediatric doses are prescribed per square metre of body surface area: dose (mg) = dose per m² × BSA (m²). The Mosteller formula estimates BSA = √(height (cm) × weight (kg)/3600).
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.
มิลลิลิตรต่อนาที
60/60 = 1 mL/min
อัตราการหยด
R = 1·10 = 10 gtt/min
คำตอบ
R = 10 gtt/min
6.อัตราการให้สารน้ำทางหลอดเลือดดำ
คำตอบ: D = 10 mcg/min
Dose-based infusions: concentration = amount of drug in the bag/bag volume. Pump rate (mL/h) = dose per hour/concentration, and dose per hour = mL/h × concentration. Convert per-minute doses to per-hour (× 60) and keep the mass units the same (1 g = 1000 mg, 1 mg = 1000 mcg).