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Ad: ____________________ Tarih: ____________
1.Kolay
Oseltamivir is used to treat or prevent which infection?
ATuberculosis
BInfluenza
CHIV
DHerpes simplex
2.Kolay
What is a prodrug?
AA drug that prevents or reverses the effect of another drug in the body
BA drug that is inactive until the body converts it into its active form
CA drug that is given before surgery
DA drug that has passed all clinical trials
3.Kolay
Which adverse effect of ethambutol requires vision checks?
AOptic neuritis, with blurred vision and colour blindness
BCataracts that form within a few days of starting
CBleeding in the back of the eye
DPermanent dilation of the pupils
4.Orta
A patient with Addison's disease on hydrocortisone develops a fever with flu. What is the usual advice?
AHalve the hydrocortisone to reduce side effects
BIncrease the dose as instructed (sick-day rules) and seek help if vomiting
CMake no change, as illness does not affect cortisol needs
DStop the hydrocortisone until the fever settles, to let the body recover
5.Orta
A patient given haloperidol develops a sudden painful twisting of the neck and the eyes roll upward. Which drug is usually given?
AAn anticholinergic such as benzatropine (benztropine)
BDantrolene by mouth to relax the twisted neck muscles
CNaloxone
DA second dose of haloperidol
6.Orta
Why is IV promethazine given with great caution?
AIt can cause severe tissue injury if it leaks or enters an artery
BIt causes a severe rise in blood pressure when it is given intravenously
CIt causes immediate kidney failure
DIt is a strong opioid that causes addiction
7.Zor
Kodein CYP2D6 tarafından morfine dönüştürülür. CYP2D6 ultra hızlı metabolizörü olan bir hastada ne olur?
AKodein yalnızca etkisiz bir bileşiğe dönüşür
BAz morfin oluştuğu için kodein neredeyse hiç ağrı kesici etki göstermez
CKodein idrarla değişmeden atılır
DDaha fazla morfin oluşur ve opioid toksisitesi riski artar
8.Zor
Why is pethidine (meperidine) avoided in older people and in kidney impairment?
AIt is not absorbed from the gut when kidney function is poor
BIt causes severe hypoglycaemia in these groups
CIts metabolite norpethidine builds up and can cause seizures
DIt has no pain-relieving effect in older people
Cevap anahtarı
1. B · Influenza
2. B · A drug that is inactive until the body converts it into its active form
3. A · Optic neuritis, with blurred vision and colour blindness
4. B · Increase the dose as instructed (sick-day rules) and seek help if vomiting
5. A · An anticholinergic such as benzatropine (benztropine)
6. A · It can cause severe tissue injury if it leaks or enters an artery
7. D · Daha fazla morfin oluşur ve opioid toksisitesi riski artar
8. C · Its metabolite norpethidine builds up and can cause seizures
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