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1.Легка
In the United States, what is a "boxed warning" (black box warning) on a drug label?
AA label showing that the drug is a controlled substance with abuse potential
BA sign that the drug must be stored in a dark box
CA note that the drug is available without prescription
DThe strongest FDA warning about a serious or life-threatening risk
2.Легка
Який орган метаболізує більшість ліків?
AПечінка
BНирка
CСелезінка
DЛегеня
3.Легка
Which harmless effect of rifampicin should patients be warned about?
AGreen colouring of the stools
BWhite spots on the teeth
COrange-red colouring of urine, sweat and tears
DBlue colouring of the fingernails and lips
4.Середня
How should a topical corticosteroid cream usually be applied?
AOn broken, infected skin to speed healing
BAs a thin layer to the affected area only, as directed
CUnder a tight plastic dressing every night without advice
DAs a thick layer over the whole body
5.Середня
A patient has oral mucositis after chemotherapy. Which advice is appropriate?
AUse an alcohol-based mouthwash several times a day to kill germs
BUse a soft toothbrush and rinse with saline or a bland mouthwash
CBrush hard with a firm toothbrush to remove debris
DEat spicy and acidic foods to stimulate healing
6.Середня
Why should a patient rinse the mouth after using an inhaled corticosteroid?
ATo prevent a fall in blood glucose
BTo make the drug work faster in the lungs
CTo reduce the risk of oral thrush (candidiasis) and hoarseness
DTo stop the drug being absorbed too quickly into the blood
7.Складна
Lithium taken in the first trimester of pregnancy has been linked to which type of birth defect?
ACleft lip and palate only
BLimb defects similar to thalidomide
CNeural tube defects such as spina bifida
DHeart malformations, such as Ebstein's anomaly
8.Складна
A patient taking azathioprine is prescribed allopurinol for gout. What is the main danger?
ASevere bone marrow suppression, because azathioprine breakdown is reduced
BLiver enzyme induction, making azathioprine ineffective
CGout becomes worse because allopurinol is inactivated by azathioprine
DSevere hypertension from the combination
Ключ відповідей
1. D · The strongest FDA warning about a serious or life-threatening risk
2. A · Печінка
3. C · Orange-red colouring of urine, sweat and tears
4. B · As a thin layer to the affected area only, as directed
5. B · Use a soft toothbrush and rinse with saline or a bland mouthwash
6. C · To reduce the risk of oral thrush (candidiasis) and hoarseness
7. D · Heart malformations, such as Ebstein's anomaly
8. A · Severe bone marrow suppression, because azathioprine breakdown is reduced
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