Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin as a constant IV infusion without a loading dose. The half-life is 8 h. What percentage f of the steady-state level has been reached after 8 h?
Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 8 h. What percentage f of the steady-state level has been reached after 24 h?
Practice exercise (made-up values, not clinical guidance). A 65 kg patient receives a theophylline infusion. The clearance is 0.04 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 12 mg/L?
Practice exercise (made-up values, not clinical guidance). A 73 kg patient is to be loaded with digoxin tablets to reach a level of 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 2.5 h. The target is a peak of 6 mg/L and a trough of 1 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A 52 kg patient has a digoxin level of 0.4 mcg/L; the target is 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
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