Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 6 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 3.5 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 80 kg needs a loading dose of gentamicin to reach a level of 6 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 110 mg of tobramycin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 140 mg of gentamicin. The level back-extrapolated to time zero is 7 mg/L and the half-life is 3.5 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 37.5 mg/h with no loading dose. The patient's clearance is 2.5 L/h and the half-life is 8 h. What is the level C after 18 h?
Practice exercise (made-up values, not clinical guidance). A patient's tobramycin half-life is 2.5 h. The target is a peak of 10 mg/L and a trough of 1 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
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