Practice exercise (made-up values, not clinical guidance). A patient who weighs 69 kg needs a loading dose of tobramycin to reach a level of 6 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives lidocaine as a constant IV infusion without a loading dose. The half-life is 1.5 h. What percentage f of the steady-state level has been reached after 3 h?
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 500 mL/min. What infusion rate R in mg/min keeps the steady-state level at 2.5 mg/L?
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 6 mg/L at 2 h and 0.9 mg/L at 10 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion is started without a loading dose. The half-life in this patient is 9 h. How long t does it take to reach 95% of the steady-state level?
Practice exercise (made-up values, not clinical guidance). An 82 kg patient has a digoxin level of 0.5 mcg/L; the target is 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
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