Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 35 mg/L. The half-life is 6 h, and the drug is eliminated by first-order kinetics. What is the level C 23 h later?
Practice exercise (made-up values, not clinical guidance). In a patient, gentamicin has an elimination half-life of 2.5 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 220 mg of tobramycin. The level back-extrapolated to time zero is 10 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 6 mg/L at 1 h and 3 mg/L at 3 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). A 56 kg patient has a digoxin level of 0.5 mcg/L; the target is 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A 62 kg patient has a digoxin level of 0.4 mcg/L; the target is 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
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