Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of gentamicin, which has a half-life of 2 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). The elimination rate constant of gentamicin in a patient is 0.198 h⁻¹. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 95 mL/min. What infusion rate R in mg/h gives a steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 500 mL/min. What infusion rate R in mg/min keeps the steady-state level at 2.5 mg/L?
Practice exercise (made-up values, not clinical guidance). A 61 kg patient takes oral aminophylline (S = 0.8, F = 1) every 12 h. The theophylline clearance is 0.035 L/kg/h. Each dose is 500 mg of aminophylline. Find the average steady-state level Css,avg.
Practice exercise (made-up values, not clinical guidance). A 69 kg patient takes oral aminophylline (S = 0.8, F = 1) every 12 h. The theophylline clearance is 0.05 L/kg/h. Each dose is 200 mg of aminophylline. Find the average steady-state level Css,avg.
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