Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 8 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 5 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 9 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 7.5 h later?
Practice exercise (made-up values, not clinical guidance). A 51 kg patient is to be loaded with digoxin tablets to reach a level of 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 170 mg of tobramycin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). An 80 kg patient has a phenytoin level of 8 mg/L; the target is 20 mg/L. The drug is given intravenously as phenytoin sodium (S = 0.92), and the volume of distribution is 0.7 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A patient's tobramycin half-life is 2 h. The target is a peak of 6 mg/L and a trough of 1 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
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