Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 8 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 3.5 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 25 mg/L. The half-life is 12 h, and the drug is eliminated by first-order kinetics. What is the level C 36 h later?
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 850 mL/min. What infusion rate R in mg/min keeps the steady-state level at 3 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 130 mg of tobramycin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). An 84 kg patient takes oral aminophylline (S = 0.8, F = 1) every 12 h. The theophylline clearance is 0.03 L/kg/h. What dose D in mg gives an average steady-state level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). A theophylline infusion is started without a loading dose. The half-life in this patient is 8 h. How long t does it take to reach 75% of the steady-state level?
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