Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 7 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 11 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 67 kg needs a loading dose of tobramycin to reach a level of 8 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A 95 kg patient is to be loaded with digoxin tablets to reach a level of 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 140 mg of tobramycin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 3 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A 70 kg patient has a digoxin level of 0.5 mcg/L; the target is 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A 67 kg patient on regular gentamicin doses is at steady state. The target is a peak of 8 mg/L and a trough of 0.5 mg/L, and the volume of distribution is 0.3 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
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