Practice exercise (made-up values, not clinical guidance). A patient who weighs 107 kg needs a loading dose of gentamicin to reach a level of 6 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of vancomycin, which has a half-life of 12 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 300 mg of gentamicin. The level back-extrapolated to time zero is 10 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). An 83 kg patient receives a theophylline infusion. The clearance is 0.045 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 125 mg/h with no loading dose. The patient's clearance is 5 L/h and the half-life is 10 h. What is the level C after 15 h?
Practice exercise (made-up values, not clinical guidance). A patient's tobramycin half-life is 2 h. The target is a peak of 8 mg/L and a trough of 1 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
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