Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 8 h. What percentage f of the steady-state level has been reached after 24 h?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 9 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 6.5 h later?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 110 mg of gentamicin. The level back-extrapolated to time zero is 7 mg/L and the half-life is 3.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 190 mg of tobramycin. The level back-extrapolated to time zero is 10 mg/L and the half-life is 3 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 95 kg patient on regular tobramycin doses is at steady state. The target is a peak of 10 mg/L and a trough of 1 mg/L, and the volume of distribution is 0.3 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
Practice exercise (made-up values, not clinical guidance). An 87 kg patient on regular tobramycin doses is at steady state. The target is a peak of 8 mg/L and a trough of 0.5 mg/L, and the volume of distribution is 0.25 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
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