Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 10 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 8.5 h later?
Practice exercise (made-up values, not clinical guidance). In a patient, gentamicin has an elimination half-life of 2 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). A 93 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 12 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 100 mg of gentamicin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 59 kg patient has a theophylline level of 9 mg/L; the target is 15 mg/L. The drug is given intravenously as aminophylline (S = 0.8), and the volume of distribution is 0.5 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). An 81 kg patient takes oral aminophylline (S = 0.8, F = 1) every 8 h. The theophylline clearance is 0.03 L/kg/h. What dose D in mg gives an average steady-state level of 10 mg/L?
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